Process for producing pravastatin on large scale
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- GUANGDONG BLUE TREASURE PHARMA
- Publication Date
- 2016-08-03
Smart Images
Figure 1 Figure 2
Abstract
Description
technical field
[0001] The invention relates to the technical field of medicine preparation, in particular to a process for large-scale production of pravastatin. Background technique
[0002] Pravastatin is a 3-hydroxy 3-methylglutaryl-CoA reductase inhibitor, initially used to treat hyperlipidemia and familial hypercholesterolemia, and later the indications continued to expand, it can slow down the development of atherosclerosis, reduce Coronary atherosclerotic lesions and clinical cardiovascular events.
[0003] The production of pravastatin is usually obtained by a two-step fermentation process, although there are also reports or patents (WO99 / 10499, WO2007 / 147827, US6,274,360 and EP1,266,967) describing that the method for one-step fermentation can be used to produce pravastatin, but due to technical For reasons such as complexity and production efficiency, the industrial production of pravastatin is still based on two-step fermentation.
[0004] The two-step fermenta...