Polysaccharide MA from Mytilus coruscus with hypolipidemic activity and preparation method thereof

A technology of mussel polysaccharide and hypolipidemic drug, applied in the field of medicine

Active Publication Date: 2009-02-04
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far there is no relevant report on the isolation of mussel polysaccharide MA with hypolipidemic activity from the marine organism blue mussel

Method used

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  • Polysaccharide MA from Mytilus coruscus with hypolipidemic activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1. Preparation of mussel polysaccharide MA

[0013] Take 16 kg of fresh blue mussels grown in the sea area of ​​Shengsi, Zhejiang, China, prepare a homogenate with a blender, boil water for extraction twice, add 3 times the volume of water for the first time, extract for 2 hours, and add 2 times for the second time volume of water, extract for 1 hour, centrifugally filter, combine the filtrate, add 4 times the volume of 95% ethanol after concentrating the filtrate, stir well, and let it stand for 5 hours. Ethanol, stirred evenly, centrifugally filtered, the precipitate was washed 3 times with an equal volume of absolute ethanol and centrifugally dried, and then subjected to 2 times of Savager method to remove protein, dissolved in distilled water, and freeze-dried to obtain about 960 g of crude mussel polysaccharide. Take about 6g of the crude product and dissolve it in 10ml 0.05mol L -1 In the NaCl solution, centrifuge to remove the insoluble matter, put on...

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Abstract

The invention relates to the technical field of a medicine, provides a mussel polysaccharide MA separated from common mussel and a preparation method thereof. Proven through blood fat lowering test in animal bodies, the mussel polysaccharide MA is significant in treating white rat hyperlipemia induced by high-fat feedstuff, and can reduce the level of total cholesterol, triglyceride and low density lipoprotein in white rates. The action of the mussel polysaccharide MA is equal to the action of pravastatin as a positive medicine or Xuezhikang. Accordingly, the mussel polysaccharide MA can be applied for preparing medicines or food for lowering blood fat, which is of far reaching importance for making the most of living marine resources.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a polysaccharide MA isolated from marine organisms purple mussels and a preparation method thereof. Background technique [0002] Blue mussel (Mytilus galloprovincialis Lamarck) is a marine organism of the genus Mytilus in the family Mytilidae, and is widely distributed in the coastal areas of China. Blue mussel is wedge-shaped, the shell is lighter and thinner, but tougher, the shell length is generally 70-90mm, dark brown or purple brown, and the surface is smooth. Blue mussel is rich in resources, high in yield, delicious in meat and rich in nutrition. It is an important source of high-grade protein. In addition to being eaten fresh, it can also be made into delicious food such as canned food, mussel oil and dried products. In addition to being used as tonics and medicaments in medicine, it is also an important raw material for extracting vitamin D (Wang Zhenrui. Chinese Zool...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P3/06A23L1/28A23L1/327A23L1/33A23L1/09A23L1/30A23L33/00A23L33/10A23L33/125
Inventor 易杨华李玲马明华张文储智勇李树林
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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