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Composite nano fiber support material, as well as preparation method and application in bone repairing aspect

A technology of composite nanofibers and scaffold materials, applied in the field of bone repair materials, to achieve the effect of facilitating deposition, simple and feasible preparation method, and enhancing mechanical strength

Inactive Publication Date: 2012-06-20
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of polylactic acid-glycolic acid / hydroxyapatite / simvastatin composite nanofibrous scaffolds by electrospinning has not been reported yet.

Method used

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  • Composite nano fiber support material, as well as preparation method and application in bone repairing aspect
  • Composite nano fiber support material, as well as preparation method and application in bone repairing aspect
  • Composite nano fiber support material, as well as preparation method and application in bone repairing aspect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Dissolve 0.12 g of PLGA (molecular weight is 80,000, mass ratio of PLA to PGA is 85:15) in 2 mL of mixed solvent of chloroform and N,N-dimethylformamide (volume ratio is 1:1 ), after magnetic stirring for 4 hours, the chloroform and dimethylformamide mixed solution of PLGA was obtained; The PLGA nanofiber scaffolds were vacuum-dried for later use. Its fiber diameter is between 100nm and 200m, the fibers are interlaced, and there are a small amount of spindles, such as figure 1 (a).

Embodiment 2

[0028] Dissolve 0.006g of hydroxyapatite in a mixed solvent of 0.5mL chloroform and N,N-dimethylformamide (volume ratio is 1:1), and add it to the PLGA solution prepared in Example 1 after ultrasonic dissolution , and then spun by an electrospinning device (voltage 18V, distance 15cm) to prepare PLGA / HA nanofiber scaffolds, which were vacuum-dried for later use. Its fiber diameter is 50-100nm, such as figure 1 (b) shown.

Embodiment 3

[0030] Dissolve 0.012g of hydroxyapatite in a mixed solvent of 0.5mL chloroform and N,N-dimethylformamide (volume ratio is 1:1), and add it to the PLGA solution prepared in Example 1 after ultrasonic dissolution , and then spun by an electrospinning device (voltage 18V, distance 15cm) to prepare PLGA / HA nanofiber scaffolds, which were vacuum-dried for later use. The fiber diameter is 20-50nm, and contains more spindles, and the resulting fiber scaffold has larger pores, up to several microns, such as figure 1 (c) shown.

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Abstract

The invention belongs to the technical field of bone repairing materials, and relates to a PLGA / HA / S (Poly(Lactic-co-Glycolic Acid) / Hydroxyapatite / Simvastatin) medicament-carrying composite nano fiber support material as well as a preparation method and application in the bone repairing aspect. The material is prepared by preparing a carrier polymer mixed solution containing simvastatin from hydroxyapatite, simvastatin and PLGA, and processing by a high-voltage electrostatic spinning device, wherein the mass ratio of hydroxyapatite to PLGA and simvastatin to PLGA is (1:100)-(1:10) respectively. The physical and chemical performances and degradation rate of the material are controlled by controlling the blending ratio, reaction temperature, time and other factors; the PLGA / HA / S blended medicament-carrying nano fiber has good biocompatibility; the shape of the material is similar to extracellular matrix, thereby being beneficial to the adhesion and growth of cells; and the material has better biodegradability, and can release the main ingredient of bone tissues, namely hydroxyapatite and a medicament for promoting osteogenesis, namely simvastatin, thus the biomaterial is particularly suitable to be used as a bone repairing material.

Description

technical field [0001] The invention belongs to the technical field of bone repair materials, and relates to a PLGA / HA / S drug-loaded composite nanofiber scaffold material, a preparation method and an application in bone repair. Background technique [0002] Statins are hydroxymethylglutaryl-CoA reductase inhibitors. As classic lipid-lowering drugs, they are widely used in the treatment of hyperlipidemia. Simvastatin is one of the statins. Its chemical structure is as follows: : [0003] [0004] The latest research shows that statins, especially simvastatin, can promote the expression of bone morphogenic protein in osteoblasts and promote the repair of bone defects. Many scholars have also done a lot of research. Wu Zhe [International Journal of Oral and Maxillofacial Surgery 37 (2008) 170-176] et al prepared a simvastatin sustained-release material for the repair of alveolar bone defects. Tomomi Tanigo et al [Journal of Controlled Release 143(2010) 201-206] used degra...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/46A61L27/18D01F6/92D01F1/10D01D5/00
Inventor 孙宏晨姜力铭孙海珠张恺杨柏
Owner JILIN UNIV
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