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138 results about "Lovastatine" patented technology

Method for utilizing monascus to convert yam to produce functional food

The invention discloses a method for utilizing monascus to convert yam to produce a functional food and relates to the technical field of bioengineering. According to the preparation method, sequentially through the steps of enlarged culture in a test tube, liquid shake-flask culture and enlarged culture in a seed tank, solid fermental cultivation, drying and smashing, the functional food which regulates blood lipids, blood sugar and blood pressure, resists radiation and inhibits tumor is obtained. According to the method, the yam, rice, wheat, corn and sorghum and the like are taken as solid substrates, monascus is taken as a strain to convert yam saponins through solid fermentation, monascus pigment and monascus polysaccharides are synthesized; in the obtained product, the content of the saponins is 2-20 mg/g of dry substrate, the content of the monascus polysaccharides is 10-100 mg/g of dry substrate, the content of lovastatin is 0.5-10 mg/g of dry substrate, the content of the monascus pigment is 1-20 mg/g of dry substrate, and the method can be used for extracting the saponins, the monascus polysaccharides, lovastatin and the monascus pigment and producing tablets or capsules for treating blood lipids, blood sugar and blood pressure, resisting radiation and inhibiting tumor.
Owner:JIANGSU UNIV

Method for producing lovastatin by fermentation and fermentation medium used by same

The invention provides a method for producing lovastatin by fermentation and a fermentation medium used by the same. The fermentation medium takes maltose as a carbon source and does not contain glucose. The method for producing lovastatin by fermentation by using the fermentation medium is characterized in that: Aspergillus terreus for producing lovastatin is cultured by fermentation in the fermentation medium provided by the invention. The method provided by the invention improves the fermentation unit of lovastatin by about 10%, simultaneously shortens the fermentation period, lowers the production cost, and is suitable for industrialized production.
Owner:PEKING UNIV FOUNDER GRP CO LTD +2

Preparation method and application of functional monascus-fermented corn bran food

The invention relates to a preparation method and application of a functional monascus-fermented corn bran food, and belongs to the fields of biological fermentation and medicines. According to the preparation method and application of the functional monascus-fermented corn bran food, disclosed by the invention, monascus is used as an original strain for culturing liquid by shaking a flask, liquid seeds are subjected to propagation, and solid fermentation is performed on corn bran, so that functional foods containing lovastatin and monascus pigments are obtained. The food contains 10-50mg / g of polysaccharide, 0.5-5mg / g of lovastatin and 0.4-6mg / g of monascus pigments. The functional food prepared by the method disclosed by the invention can be used for producing health care foods capable of regulating blood pressure and blood fat, or extracting active components, namely the polysaccharide, the lovastatin and the monascus pigments, so as to be used for producing medicines for treating hyperlipaemia and diabetes.
Owner:JIANGSU UNIV

Red yeast rice extract oil and the preparation and application of the soft capsule thereof

Disclosed is a red yeast rice extract oil and the preparation and application of the soft capsule thereof. The preparation method comprises: adding solvent into the red yeast rice medicinal material, heating for backflow for 2-5 hours; filtering, adding the filter residue into the solvent, heating for backflow for 1-4 hours; merging the filtrates; condensing at 50-90 degrees centigrade into extract with relative density of 1.1-1.4 at 25 degrees centigrade; adding ethanol by amount of 1-4 times (mass) of the red yeast rice medicinal material into the extract; dissolving, filtering, recovering ethanol to obtain stiff paste; adding ethanol by amount of 0.5-1 times (mass) of the red yeast rice medicinal material into the stiff paste; distilling to dryness at 60-95 degrees centigrade, insulating thermal for 1-5 hours; adding 0.5-4 times of ethanol into the extract; adding 0.5-5 times of vegetable oil, stirring uniformly at 50-70 degrees centigrade; recovering the ethanol to obtain the red yeast rice extract oil. The content of the active ingredient: lovastatin in the soft capsule prepared by the red yeast rice extract oil is 0.2-1.2wt%; the soft capsule is applied for preparing medicament for treating hyperlipemia; The invention can remove the large amount of unavailability components in the red yeast rice, and increases the content of lovastatin compounds in the extract of per weight unit effectively.
Owner:云南永安制药有限公司

Composition for prevention and treatment of cardio-cerebrolvascular disease

The invention relates to a composite which prevents and treats cardiovascular and cerebrovascular diseases. The composite consists of the materials according to the parts by weight: 10 to 200 parts of Konjak refined powder, 1 to 100 parts of hawthorn P. E., 1 to 100 parts of fructus lycii P.E, 1 to 100 parts of mulberry seed P. E. and 0.01 to 5 parts of red rice (counted by lovastatin). The composite can play a positive part in preventing and treating the cardiovascular and cerebrovascular diseases, intervenes in a plurality of forming links of cardiovascular and cerebrovascular diseases and can be used for preparing medicines, health food or food, and the like, which can prevent and treat cardiovascular and cerebrovascular diseases.
Owner:毛晓敏

New salts of HMG-CoA reductase inhibitors

Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of different species identified as species belonging to Aspergillus, Monascus, Nocardia, Amycolatopsis, Mucor or Penicillium genus, some are obtained by treating the fermentation products using the methods of chemical synthesis or they are the products of total chemical synthesis. The present invention relates to the new amine salts of HMG-CoA reductase inhibitors, the preparation thereof, the preparation of pure HMG-CoA reductase inhibitors via amine salts thereof, use of the amine salts of HMG-CoA reductase inhibitors in the process for semisynthetic preparation of HMG-CoA reductase inhibitors, use of the amine salts of HMG-CoA reductase inhibitors in the process for biotechnological modification of HMG-CoA reductase inhibitors as well as the conversion of the amine salts of HMG-CoA reductase inhibitors into the pharmaceutically acceptable salts of the HMG-CoA reductase inhibitors and the conversion of the amine salts of HMG-CoA reductase inhibitors into the HMG-CoA reductase inhibitors in the lactone form.
Owner:LEK PHARMA D D

Production tech. of acid type lovastatin and production tech of its salt and pharmaceutical application

InactiveCN100999471AIncrease the burden on the liverAvoid side effectsOrganic chemistryMetabolism disorderDrugToxicity
A lovastatin acid and lovastatin acid salt production processes and their application, to solve the problem of significantly toxicity of lactone form lovastatin, such as liver injury and causing muscle pain and elevating transaminase. The invention uses 95% ethanol and NaOH (13 ~ 100:8 that m lactone structure: mNaOH) to modulate into alkaline solution, makes lactone lovastatin powder dissolved in solution, and uses HCl adjust PH to obtain the acid form and salt state compounds, widely used for lipid drug.
Owner:吴娟
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