Aspergillus clavatus-32 strain capable of highly yielding Lovastatin and application of Aspergillus clavatus-32 strain

Abstract

The invention belongs to the field of biotechnology microorganisms, and particularly relates to an Aspergillus clavatus-32 strain producing Lovastatin through liquid fermentation, application and a fermentation producing method. The Aspergillus clavatus-32 strain is high in Lovastatin yield and growing speed, large in sporulation quantity and simple to culture. Under the conditions that initial pH of a fermentation culture medium is 5.2 and culture temperature is 28 DEG C, after the liquid fermentation culture medium and fermentation conditions are optimized and the Ac-32 strain is fermented in a 5L fermentation tank for 110-140h, yield of Lovastatin can reach about 200-250mg / L.

Description

technical field

[0001] The invention belongs to the field of biotechnology microorganisms, in particular to a strain of Aspergillus clavus that produces Lovastatin by liquid fermentation ( Aspergillus clavatus ) Ac-32 strain, application and fermentation production method. Background technique

[0002] In recent years, the prevalence, incidence and risk factors of cardiovascular disease in the Chinese population have continued to rise. According to the latest data from the National Disease Surveillance System, the proportion of cardiovascular disease in total deaths in my country has increased from 37.5% to 40.7%. Lovastatin, a secondary metabolite of Aspergillus, has become one of the best-selling drugs for the treatment of cardiovascular diseases due to its clear mechanism of action and remarkable clinical efficacy in the prevention and treatment of hyperlipidemia, atherosclerosis and cardiovascular and cerebrovascular diseases .

[0003] In 1979, Japanese scholar Akira ...

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