36 results about "Red yeast rice extract" patented technology

The invention discloses a red yeast rice extract and a preparation method and a quality test method thereof. The main active ingredient of the extract is lovastatin, the content of which is more than 3 percent. The extract is prepared by subjecting a medical material of red yeast rice to extraction with an organic solvent, water decoction after the volatilization of the solvent, precipitation collection by siphonage and configuration, mixing with excipients and drying. The preparation method improves the content of lovastatin. The invention also provides a quality control method for identifying the ingredients and measuring content.

Medicaments and therapeutic compositions comprise (1) at least one polyunsaturated fatty acid, at least one pharmaceutically acceptable derivative of a polyunsaturated fatty acid or mixtures thereof and (2) Red Yeast Rice extract comprising about 0.8 wt.% or more monacolin K. One source of component (1) is fish oil. The compositions are useful for lowering cholesterol and / or triglyceride levels in a subject.

Wild Garlic (Bear's or Forest Garlic, Allium ursinum) can be combined with cultivated high-allicin garlic (Allium sativum) and extracts of the same to take advantage of the previously unknown synergism of preparations made from these two garlic species. There is a substantial cost savings over the use of pure, Wild Garlic and an elimination of the side effects found with the chronic ingestion of high levels of cultivated allicin-rich garlic (Allium sativum). The resulting combination has demonstrated benefits with regard to blood lipids regulation in individuals in need thereof that are two or more times that expected from the use of either garlic species taken singularly. Blood pressure regulating benefits are maintained or improved, the odor-causing potential of high-allicin garlic is reduced, and significant improvements are found in the areas of total, LDL, and VLDL cholesterol and triglycerides, benefits far beyond the merely additive. HDL cholesterol levels also are improved. It is to be expected that these benefits, in addition, can be extended through the concurrent intake of folic acid, red yeast rice extracts and other compounds proposed for improving cardiovascular health. Still further, a variety of defined delivery approaches, including, but not limited to controlled releases, especially those including mucoadhesive, can be utilized to improve the effects taught herein.

Medicaments and therapeutic compositions comprise (1) a mixture comprising (A) EPA, pharmaceutically acceptable derivatives of EPA or mixtures thereof, and, optionally, (B) DHA, pharmaceutically acceptable derivatives of DHA or mixtures thereof, wherein the weight ratio of A:B is about 7.5:1 or more, and (2) monacolin K, a source of monacolin K or mixtures thereof. One source of component (1) is fish oil. One source of monacolin K is Red Yeast Rice extract. The compositions are useful for lowering cholesterol and / or triglyceride levels in a subject.

Compositions comprising Red Yeast Rice extracts which comprise greater than 5 wt. % monacolin K are useful for lowering cholesterol and / or triglyceride levels in a subject.

The invention discloses red yeast rice rich in GABA and a preparation method of the red yeast rice. A variety "Nanton84" (black kernelled rice) is screened from 60 different kinds of rice (comprising polished rice, red rice and black kernelled rice), and the content of gamma-amino butyric acid (GABA) in catalytic "Nanton84" sprouted brown rice is as high as 24.82mg / 100g which is 4.0 times that of a check variety "Fu rice No. 8". The "Nanton84" sprouted brown rice is used as a substrate for performing a fermentation test, monascus strains CICC 5008 with the high yield of GABA and without production of citrinin are screened from 49 separated and collected monascus strains, and the content of the GABA in the fermented product namely red yeast rice is as high as 22.43mg / 100g which is 93.9% higher than that of check strains CICC 5004. The preparation method of the red yeast rice rich in the GABA, disclosed by the invention, is simple, the content of the GABA in the red yeast rice which is prepared under optimal fermentation conditions is as high as 26.54mg / 100g, and no citrinin is detected.

Disclosed is a red yeast rice extract oil and the preparation and application of the soft capsule thereof. The preparation method comprises: adding solvent into the red yeast rice medicinal material, heating for backflow for 2-5 hours; filtering, adding the filter residue into the solvent, heating for backflow for 1-4 hours; merging the filtrates; condensing at 50-90 degrees centigrade into extract with relative density of 1.1-1.4 at 25 degrees centigrade; adding ethanol by amount of 1-4 times (mass) of the red yeast rice medicinal material into the extract; dissolving, filtering, recovering ethanol to obtain stiff paste; adding ethanol by amount of 0.5-1 times (mass) of the red yeast rice medicinal material into the stiff paste; distilling to dryness at 60-95 degrees centigrade, insulating thermal for 1-5 hours; adding 0.5-4 times of ethanol into the extract; adding 0.5-5 times of vegetable oil, stirring uniformly at 50-70 degrees centigrade; recovering the ethanol to obtain the red yeast rice extract oil. The content of the active ingredient: lovastatin in the soft capsule prepared by the red yeast rice extract oil is 0.2-1.2wt%; the soft capsule is applied for preparing medicament for treating hyperlipemia; The invention can remove the large amount of unavailability components in the red yeast rice, and increases the content of lovastatin compounds in the extract of per weight unit effectively.

Medicaments and therapeutic compositions comprise a composition (1) comprising (A) EPA, pharmaceutically acceptable derivatives of EPA or mixtures thereof, and, optionally, (B) DHA, pharmaceutically acceptable derivatives of DHA or mixtures thereof, wherein the weight ratio of A:B is about 7.5:1 or more, and a composition (2) comprising monacolin K, a source of monacolin K or mixtures thereof. One source of component (1) is fish oil. One source of monacolin K is Red Yeast Rice extract. The compositions are useful for lowering cholesterol and / or triglyceride levels in a subject.

Compositions comprising Red Yeast Rice extracts which comprise greater than 5 wt. % monacolin K are useful for lowering cholesterol and / or triglyceride levels in a subject.

The invention discloses a red yeast rice and euphausia superba oil soft capsule composition having a function of reducing blood fat. The invention relates to a composition which takes a red yeast rice extract and euphausia superba oil as major ingredients, and the composition has a function of regulating blood fat. The blood fat reducing composition disclosed by the invention is concrete in ingredient, low in taking dosage and is safe and effective, and the composition disclosed by the invention is stronger in pharmacological activity compared with the single red yeast rice extract and and the euphausia superba oil. The composition, as a chemical composition, shows a synergistic effect, and the composition can be used for preparing medicines, health care food and food having the function of reducing blood fat.

The invention relates to the technical field of medicines and discloses a pharmaceutical composition with functional red yeast rice active ingredients and docosahexaenoic acid and application of the pharmaceutical composition for preparing anti-tumor drugs. The pharmaceutical composition contains functional red yeast rice extracts with lovastatin as main active ingredients and docosahexaenoic acid. The composition has the better anti-tumor action effect compared with the action generated when each component is used independently and has the more obvious cell inhibiting effect, and therefore the pharmaceutical composition can be used for tumor treatment.

The invention provides a method for rapidly and quantitatively determining the content of citrinin in red yeast rice, and belongs to the technical field of citrinin content detection. The method for determining the content of citrinin in the red yeast rice comprises the steps that a citrinin standard solution with known concentration is prepared, the fluorescence intensity of the citrinin standardsolution is measured, a standard curve equation of citrinin is established, the red yeast rice is ground, red yeast rice powder is extracted by ultrasonic, an extracting solution is dried under reduced pressure to obtain red yeast rice extract, the red yeast rice extract is redissolved with methanol with pH of 1-2, the red yeast rice extract is further diluted by 200-800 times with methanol withpH of 1-2, the fluorescence intensity of the red yeast rice extract is measured, the fluorescence intensity to be measured is put into the citrinin standard curve equation, and the content of citrininin the red yeast rice to be detected is calculated. The method solves the problem of a phenomenon of fluorescence quenching of citrinin in the red yeast rice extract, and provides a simple and accurate detection method for detecting the content of citrinin in the red yeast rice.

The present invention discloses an auxiliarily blood lipid lowering seal oil and purple perilla seed oil soft capsule which is characterized by adding seal oil and purple perilla seed oil as main raw materials into red yeast rice extract and being prepared by mixing, homogenizing, soft capsule filling, and packaging. The components are in the weight percentage: 10-30% of seal oil, 20-40% of purple perilla seed oil, and 30-50% of red yeast rice extract. The seal oil, purple perilla seed oil, and red yeast rice extract are organically combined to enable each component to be mutually complementary and mutually reinforcing and are subjected to homogenization treatment to enable a high small molecule active material yield, which can significantly increase the activity. The auxiliarily blood lipid lowering seal oil and purple perilla seed oil soft capsule is easy for human body absorption and utilization and convenient for consumption, can play well health-care function in auxiliarily lowering blood lipids, blood pressure and blood sugar, and is an ideal health-care food for middle-aged population with high blood pressure, blood lipids and blood sugar.

The invention relates to a compressed red yeast rice candy, which belongs to the technical field of health food. The red yeast rice tablet compressed candy of the present invention contains isomaltooligosaccharide, corn starch, maltodextrin, red yeast rice powder, and xylitol. The red yeast rice tablet of the present invention, on the basis of maintaining the functions of the original components, the compatibility of each component produces a synergistic effect. It has stronger anti-fatigue and maintains normal gastrointestinal function; it can also adjust blood lipids, blood pressure, and blood sugar in the normal range; it also has the effect of preventing osteoporosis, and it is the best choice for people to maintain gastrointestinal health, blood health, and bone health Must choose food, in order to achieve the purpose of prolonging life.

The invention relates to a composition which takes red kojic rice extract, astaxanthin and phytosterol as main components. The composition has blood lipid regulation effect. The composition has clear components and is prepared by compounding three different medicinal substances; the blood lipid regulation effect is expressed by utilizing different acting principles and target points; the composition has the characteristics of small oral dosage and capability of being both used as medicine and food and is a safe and effective composition for lowering blood lipid; compared with single red kojic rice extract, the astaxanthin and the phytosterol, the composition has stronger blood lipid lowering activity. The synergistic effect of the compound composition is represented and the composition can be used for preparing medicines and health foods, which have the blood lipid regulation effect.

The invention relates to a medicinal composition comprising effective dose of red yeast rice extract and at least a medicament for resisting platelet aggregation, especially compound medicinal preparation of Clopidogrel red yeast rice extract and its use, the preparation can also contain right amount of liver-protective agent, and at least one kind of pharmaceutically acceptable excipient.

The invention discloses a functional product with effect of preventing and treating cardiovascular and cerebrovascular diseases and a preparation method thereof. The functional product is prepared from the following raw materials in parts by weight: 15 to 25 parts of L-arginine, 6 to 14 parts of grape seed extract, 20 to 30 parts of bromelain, 12 to 18 parts of red yeast rice extract, 2 to 8 parts of nattokinase, 5 to 9 parts of vitamin C, 2 to 8 parts of orange powder and 6 to 15 parts of maltodextrin. According to the functional product, under the combined action of all the raw materials, the cardiovascular and cerebrovascular diseases are prevented and treated from multiple aspects of inhibiting generation of lipid peroxide, decomposing cholesterol, dissolving old thrombus, enhancing toughness and elasticity of blood vessels, enhancing body functions and the like; and therefore, the functional product has rapid and efficient prevention and treatment effects on the cardiovascular and cerebrovascular diseases.

The invention discloses an ulvan composition with anti-tumor activity and a preparation method thereof. The preparation method comprises the following steps: obtaining a crude extract from green algaulva lactuca by utilizing ultrasonic assisted extraction and separation of a water-extraction and alcohol-precipitation method, and performing further purification to obtain active ulvan; and mixing the active ulvan with the prepared ganoderma extract, gynostemma extract, red yeast rice extract, selenium-enriched yeast and tea polyphenol in a proportion. Animal pharmacodynamics prove that the ulvan composition has remarkable killing capability on H22 liver cancer tumors in a KM mouse body, can still achieve an excellent tumor inhibiting effect under the situation of insufficient immune, does not have remarkable side effect, and is a safe bioactive material formula with no toxicity and small side effect, so that a new way of ulva is provided to further utilization of marine drug resources,and a new choice is provided to medicines for treating or preventing tumors.

The present invention relates to a non-destructive flaw detector which includes a colorant and a color developing agent; the colorant comprises the following raw materials by mass: 20 to 25 wt% of a non-ionic surfactant, 20 to 30 wt% of a lycium ruthenicum-red yeast rice extract mixture, and the balance of a propellant; the color developing agent comprises the following raw materials by mass: 6 to10wt% cellulose nanofiber, 2 to 3wt% of a plasticizer, 1 to 2wt% of a surfactant, 7 to 10wt% of an adsorbent, 30-40wt% of ethanol, and the balance of the propellant; the non-destructive flaw detectoris not only environmentally-friendly, but also has the advantage of high detection sensitivity; moreover, the colorant and the color developing agent of the non-destructive flaw detector are ejectedby means of the propellant to the surface of a workpiece to be detected, and the non-destructive flaw detector has the advantage of simple and convenient operation.

The invention discloses a flavonoid glycoside red yeast rice lovastatin and a preparation method thereof. The flavonoid glycoside red yeast rice lovastatin is prepared from 55-60% of functional red yeast rice extract and 40-45% of ginkgo leaf extract. The ginkgo leaf flavonoid glycoside composite red yeast rice lovastatin capsule prepared by mixing, capsulation and sterile packaging is convenient for the patient to carry about and convenient for mastering the dose, and is capable of avoiding generating cholesterol, increasing the cerebrovascular flow, lowering the cerebral vascular resistance, improving the cerebrovascular circulatory function, protecting the brain cells, protecting the patient from ischemic injuries, expanding the coronary artery, preventing angina pectoris and myocardial infarction, inhibiting the platelets from aggregation, preventing thrombosis, clearing away harmful oxyradicals and enhancing the immunological competence. The flavonoid glycoside red yeast rice lovastatin has expected curative effects on coronary heart disease, angina pectoris, cerebral arteriosclerosis, senile dementia, hypertension and other diseases.

The invention provides a red yeast rice extract modified protein / cellulose composite fiber. The mass content of the fiber and a red yeast rice extract is 0.95%-1.86%, and the mass content of protein is 4.85%-9.75%. The invention also provides a preparation method of the fiber. The preparation method comprises the following steps: preparing a red yeast rice extract modified protein micro-powder dispersion liquid, preparing a blended spinning stock solution, spinning and carrying out aftertreatment. The fiber prepared by the invention contains 0.95%-1.86% of red yeast rice extract and 4.85%-9.75% of protein; the dry breaking strength of the fiber is 2.3-2.5 cN / dtex, the wet breaking strength of the fiber is 1.25-1.4 cN / dtex, and the dry breaking elongation of the fiber is 16-22%; and meanwhile, the fabric made of the fibers has good moisture absorption and quick drying properties.

The invention discloses a novel solid beverage capable of reducing blood fat. The novel solid beverage is prepared by mixing red yeast rice extract, natto extract, Chinese yam, hawthorn, peach kernel, medlar, rhizoma polygonati, liquorice, pearl barley and the like. Extraction processes of the red yeast rice and the natto can improve the utilization rate of effective components to the maximum extent, and the extraction process is simple. The red yeast rice and the natto are good medicinal materials and are wide in source and high in nutritional value. The prepared solid beverage is subjected to formula combination according to the compatibility principle of monarch, minister, assistant and guide, the effects of all the components are effectively exerted, the synergistic effect of all the components is facilitated, the theory of homology of medicine and food in traditional Chinese medicine is met, and the solid beverage has the functions of reducing blood fat and regulating the spleen and the stomach, is obvious in effect, safe and free of side effects, and is suitable for long-term use of people with hyperlipidemia and spleen and stomach regulation. In addition, the solid beverage disclosed by the invention is simple in preparation process, and the product is easy to store and use and has great market application value.

The invention discloses Tibetan red yeast rice and a preparation method thereof. The preparation method comprises the steps that 1, highland barley, auxiliary materials and a nutrient solution are mixed and then cured, and a fermentation substrate is obtained, wherein the nutrient solution comprises the following components in parts by weight: cane sugar, glutamic acid, histidine, calcium nitrate, sodium nitrate, monopotassium phosphate, n-caprylic acid, ascorbic acid, EDTA-disodium and water; (2) the fermentation substrate is inoculatedwith a monascus strain seed solution, and fermented to obtain a fermented product; and (3) the fermented product is dried to obtain Tibetan red yeast rice. The preparation method is good in process stability, small in component difference between batches and stable in quality. The nutrient solution, the fermentation process and the drying process are optimized, the content of lovastatin in the Tibetan red yeast rice is increased, and meanwhile the content of acid lovastatin can be effectively increased.

The invention discloses a ginkgo leaf flavonoid glycoside composite red yeast rice lovastatin capsule, which comprises 55%-60% of a functional red yeast rice extract and 40%-45% of a ginkgo leaf extract. The ginkgo leaf flavonoid glycoside composite red yeast rice lovastatin capsule is prepared by the technological steps of mixing, capsule making, and sterilization packaging, is effectively convenient for patients to take along and master the dosage, can prevent generation of cholesterol, increase cerebrovascular flow, reduce cerebrovascular resistance, improve cerebrovascular circulation function, protect brain cells against ischemic damage, expand coronary arteries, prevent angina pectoris and myocardial infarction, inhibit platelet aggregation, prevent thrombosis, eliminate harmful oxidation free radicals, and improve immunocompetence, and has magic curative effects on coronary heart disease, angina pectoris, cerebral arteriosclerosis, senile dementia and hypertension, etc.

The invention relates to the technical field of health food and food processing, in particular to a nutrition formula suitable for astronauts to regulate hypertension, hyperglycemia and hyperlipidemia and improve immunity and a preparation method thereof, and is characterized in that the nutrition formula suitable for astronauts to regulate hypertension, hyperglycemia and hyperlipidemia and improve immunity is prepared from fresh sea cucumbers, water, Wenshan panax notoginseng powder, a red yeast rice extract, bovine colostrum powder, Chinese wolfberry fruit powder, xylitol, papain and stevioside. The preparation method comprises the following steps: carrying out enzymolysis on fresh sea cucumbers to obtain enzymatic hydrolysate (simulating human intestinal functions to convert macromolecules into micromolecules easy to absorb), then adding Wenshan panax notoginseng powder, red yeast rice extract, bovine colostrum powder, Chinese wolfberry fruit powder, xylitol and stevioside in proportion, and carrying out blending, mixing, filling, sterilization and packaging. The product is easy to absorb after being eaten for a long time, has dietary therapy effects of regulating hypertension, hyperglycemia and hyperlipidemia and improving immunity, and is especially suitable for astronauts who execute tasks in a space environment for a long time to regulate hypertension, hyperlipidemia and hyperlipidemia and improving immunity.

A composition of red yeast krill oil soft capsules with hypolipidemic effect. The invention relates to a composition mainly composed of red yeast rice extract and Antarctic krill oil, which has the effect of regulating blood fat. The composition of the invention has clear ingredients, small dosage, is a safe and effective composition for lowering blood fat, and has stronger pharmacological activity than single red yeast rice extract and Antarctic krill oil. It embodies the synergistic effect of the chemical composition and can be used to prepare medicines, health food and food with the effect of lowering blood fat.