Red yeast rice extract oil and the preparation and application of the soft capsule thereof

Abstract

Disclosed is a red yeast rice extract oil and the preparation and application of the soft capsule thereof. The preparation method comprises: adding solvent into the red yeast rice medicinal material, heating for backflow for 2-5 hours; filtering, adding the filter residue into the solvent, heating for backflow for 1-4 hours; merging the filtrates; condensing at 50-90 degrees centigrade into extract with relative density of 1.1-1.4 at 25 degrees centigrade; adding ethanol by amount of 1-4 times (mass) of the red yeast rice medicinal material into the extract; dissolving, filtering, recovering ethanol to obtain stiff paste; adding ethanol by amount of 0.5-1 times (mass) of the red yeast rice medicinal material into the stiff paste; distilling to dryness at 60-95 degrees centigrade, insulating thermal for 1-5 hours; adding 0.5-4 times of ethanol into the extract; adding 0.5-5 times of vegetable oil, stirring uniformly at 50-70 degrees centigrade; recovering the ethanol to obtain the red yeast rice extract oil. The content of the active ingredient: lovastatin in the soft capsule prepared by the red yeast rice extract oil is 0.2-1.2wt%; the soft capsule is applied for preparing medicament for treating hyperlipemia; The invention can remove the large amount of unavailability components in the red yeast rice, and increases the content of lovastatin compounds in the extract of per weight unit effectively.

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a preparation method and application of red yeast rice extract oil and soft capsules thereof. Background technique

[0002] In 1979, Japanese scholars Endo et al. isolated the HMG-GOA reductase inhibitor Monacolink from Monascus. In 1980, American researchers Alberts et al. isolated the substance Mevinolin acid with the same structure from Aspergillus terreus. It was transformed into Lovastatin (Mevinolin) and marketed under the trade name "Mevavor", and it was widely used, which promoted the research and development of statin drugs. After that, a variety of statin drugs were launched. Based on this, the second-generation statin was launched: Simvastatin. At present, there are nearly 10 kinds of statin drugs on the market. The clinical application of nearly two decades shows that statin drugs have the characteristics of significant curative effect and good tolerance. Side effe...