Method for synthesizing statins compounds
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- 马群力
- Publication Date
- 2008-06-04
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention relates to a method for preparing statin compounds, in particular to a method for synthesizing simvastatin. In the process of preparing simvastatin, lovastatin is used as a raw material, and lovastatin is formed by ring opening under the action of primary or secondary amines Amide; then use tert-butyl dimethyl chlorosilane and other protective agents such as hexaalkyl disiloxane to protect the hydroxyl to obtain lovastatin amide disiloxane. The present invention is to use this as raw material methylation reaction to form Simvastatin A new preparation method of statin amide disiloxane and simvastatin amide disiloxane deprotection under acid catalysis, hydrolysis under alkaline conditions to form simvastatin acid, and finally ring-closing lactonization to form simvastatin. The chemical name of simvastatin is: 2,2-dimethylbutyric acid-8-{(4R,6R)-6-(2-[(1s,2s,6R,,8S,8aR)-1,2,6 ,7,8,-a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl]ethyl)}tetrahyd...