Lovastatin and niacin slow-release tablet and preparation method thereof

A technology of lovastatin and sustained-release tablets, which is applied in the field of blood lipid-lowering pharmaceutical compositions and its preparation, can solve the problems of excessive instantaneous dose, failure to achieve therapeutic effect, and toxic and side effects, so as to improve blood lipid levels, reduce Effects of Fluctuations in Plasma Drug Concentrations

Inactive Publication Date: 2009-03-25
SHAANXI BUCHANG PHARMA
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AI Technical Summary

Problems solved by technology

[0006] At present, there are more and more patents on this type of compound preparation. For example, the application of 02129253.1 discloses a sustained-release preparation in the form of a double-layer tablet containing niacin and statins. Although its principle and preparation method are simple, there are two-layer tablets. At the same time, it is digested by gastric juice, so it is difficult to ensure that the sustained-release and immediate-release parts are released according to their respective laws, which may easily cause excessive instantaneous doses or

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  • Lovastatin and niacin slow-release tablet and preparation method thereof
  • Lovastatin and niacin slow-release tablet and preparation method thereof

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Embodiment Construction

[0026] 1: Lovastatin 25g, niacin 600g, and auxiliary materials were crushed separately, passed through an 80-mesh sieve, and set aside; take niacin, HPMC K15MCR hypromellose, and mix them evenly using the principle of equal mixing; take an appropriate amount of PVP k-30 for use Dissolve 50% ethanol to make a 10% solution as a binder; take the above solid powder mixture, wet it with a binder to make a soft material, granulate it with a 20-mesh nylon sieve, and dry it at 45°C for 5 hours; Pass the granules through a 20-mesh sieve for granulation, add stearic acid according to the proportion, and mix well; measure the content of niacin in the granules, calculate the tablet weight, and press the tablets to obtain 1000 niacin sustained-release tablets, measure the hardness and release degree, and pass the test Take castor oil and HPMC RT15 hypromellose, soak overnight in ethanol, dissolve, add 03B61179 Colorcon film coating premix and water under stirring, continue stirring, and get...

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Abstract

The invention relates to a lovastatin and niacin sustained-release tablet used for reducing blood lipid and the preparation method thereof; each tablet contains 500mg of niacin and 20 mg of lovastatin. The coating form is adopted for preparation; the niacin is used as the core of the sustained-release tablet; lovastatin is dissolved in coating liquid to be used as quick release part. The lovastatin and niacin sustained-release tablet used for reducing blood lipid and the preparation method have the advantages of simple and practical preparation process, low cost, enabling the medicine release to accord with the national pharmacopoeia and the treatment requirements, well improving the clinical symptoms, reducing side effects and providing a blood-reducing medicine with low price.

Description

technical field [0001] The invention relates to a blood lipid-lowering pharmaceutical composition and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Niacin and its preparations, as vitamin drugs, have been recorded in the second part of the Chinese Pharmacopoeia in 2000. It can significantly reduce the level of VLDL and triglycerides in the blood, and has anti-atherosclerosis and coronary heart disease effects; lovastatin in It was successfully developed in China in 1996. Lovastatin raw materials and tablets are included in the ministerial standards. It is currently a commonly used blood lipid regulating drug in clinical practice. [0003] Niacin is a B vitamin that mainly affects the metabolism of cholesterol and triglycerides. Oral administration of large doses of niacin can reduce the level of VLDL and triglycerides (TG) in the blood. Long-term medication can also reduce the levels of LDL and cholesterol;...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/455A61K31/366A61K31/22A61P3/06
Inventor 赵涛
Owner SHAANXI BUCHANG PHARMA
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