Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating moist tetter, dermatitis and psoriasis

A technology for berberine and psoriasis, which is applied in the field of pharmaceutical use of 13-hexylberberine hydrochloride and 13-hexylpalmatine hydrochloride to prepare and treat eczema, dermatitis and psoriasis, and achieves inflammation and activity of psoriasis. It is effective in preventing proliferative skin lesions, eliminating inflammatory reactions and avoiding adverse consequences.

Inactive Publication Date: 2007-03-07
CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, HP-13 has no reports about its activity and use in treating eczema, dermatitis and psoriasis

Method used

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  • Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating moist tetter, dermatitis and psoriasis
  • Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating moist tetter, dermatitis and psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment one gel

[0018] Weigh:

[0019] Compound HB-13 or HP-13 0.2~2g

[0020] Surfactant 0.5~1g

[0021] Absolute ethanol 5~20ml

[0022] Propanethanol 10~20g

[0023] Carpopol 940 0.5~2g

[0024] Appropriate amount of triethanolamine

[0025] Distilled water up to 100g

[0026] The above formula is prepared into external gel medicine by gel conventional method.

Embodiment 2

[0027] The preparation of embodiment two cream

[0028] Weigh:

[0029] Compound HB-13 or HP-13 0.5~2g Glycerin 5~10g

[0030] Cetyl alcohol 6~8g Anhydrous ethanol Appropriate amount

[0031] White petrolatum 8~10g Ethyl ester 0.1g

[0032] Liquid paraffin 8~19g Monoglyceride 2~5g

[0033] Polyoxyethylene (40) stearate 2~5g Distilled water Add to 100g

[0034] Above formula is made o / w cream medicine by cream routine operation.

[0035] How to use: Use the above gel and cream to apply an appropriate amount on the affected parts of eczema and dermatitis skin infections.

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Abstract

The invention relates to a method for using alcaine 13-hexyl berberine, and relative lcaine 13-palmatine to prepare external the drug that resists dermopathy and psoriasis. And it has antibacterial activity and better treatment on eczema, etc. And its emulsion can treat psoriasis with similar effect of Simvastatin, without side effect.

Description

technical field [0001] The present invention relates to the preparation of the compound 13-hexylberberine hydrochloride (hereinafter referred to as HB-13) and its congener 13-hexylpalmatine hydrochloride (hereinafter referred to as HP-13) for external use on the skin to prevent inflammatory skin diseases such as eczema and dermatitis the use of. Background technique [0002] HB-13 molecular formula C 26 h 31 NO 4 HCl, molecular weight 457.98, has the following chemical structure: [0003] [0004] The above-mentioned HB-13 is composed of the 13th position -H in the molecule of the parent compound berberine hydrochloride (hereinafter referred to as Bo) replaced by hexyl-C 6 h 13 Substituted derivatives are obtained by reacting berberine hydrochloride with sodium borohydride dilute lye in aqueous medium to obtain dihydroberberine, and then reacting n-hexanal and dihydroberberine in acetic acid ethanol solution to generate crude hydrochloric acid 13-Hexylberberine, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K9/00A61K9/06A61P17/00A61P17/06
Inventor 郑家润张崇璞李耐三李新宇唐美育高纪伟徐兰芳
Owner CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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