142 results about "Tertiary alcohols" patented technology

An emulsified biofuel composition comprising: (A) a continuous phase comprising about 50-95 wt % of at least one liquid oil of vegetable or animal origin or mixtures thereof; (B) a water-containing dispersed phase comprising about 1-50 wt % water; (C) about 1-25 wt % of hydroxyl-containing organic compound selected from the group consisting of mono-, di-, tri- and polyhydric alcohols, provided that when a monohydric alcohol is used there is also present at least one of tert-butyl alcohol, at least one C2-C4 alkylene glycol or a mixture of both; (D) about 0.05-10 wt % of at least one emulsifier; wherein the dispersed water-containing droplets have an average particle size of less than about 20 microns. The biofuel is prepared from these components by mixing under high shear conditions, preferably with ultrasonic energy. The emulsifier(s) preferably exhibit a hydrophilic-lipophilic balance of about 8.5 to about 18 and the biofuel includes a cetane enhancer and mixture of an alcohol and mono- or poly-alkylene glycol.

A method for manufacturing hydrogen sulphate (alpha S) of the alpha-(2-chlorophenyl)-6,7dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester (clopidogrel hydrogen sulphate) of formula I, in crystalline Form I, wherein the compound of formula is separated out of a solution of clopidogrel in the form of the free base or salt in a solvent selected from the series of primary, secondary or tertiary C1-C5 alcohols, their esters with C1-C4 carboxylic acids, or optionally of mixtures thereof.

A polymer blend comprising (a) a modified block copolymer comprising (i) a polystyrene block and (ii) a polydiene block or a hydrogenated polydiene block, said polydiene block or hydrogenated polydiene block being modified to contain an average of one or more carboxyl groups; and (b) a polymer comprising a polymerization reaction product of two or more mono-ethylenically unsaturated monomers in which (i) at least one of the monomers is an acrylic or methacrylic acid ester of a non-tertiary alcohol having 1 to 14 carbon atoms, inclusive and (ii) at least one of the monomers has carboxylic acid functionality and is present in an amount ranging from about 1 to about 15 parts by weight, based on 100 parts by weight of polymer (b), and a method of priming a substrate comprising applying the blend to the substrate.

(1) A polymer compound for photoresist compositions which is high in storage stability and small swelling at the development and (2) a compound which is a raw material for such a polymer compound are provided; and (3) a photoresist composition with improved LWR containing the subject polymer compound are further provided. In detail, [1] a tertiary alcohol derivative represented by the following general formula (1) is provided.

(In the formula, wherein R¹ represents a linear alkyl group having from 1 to 6 carbon atoms, a branched alkyl group having from 3 to 6 carbon atoms or a cyclic alkyl group having from 3 to 6 carbon atoms; R² represents a hydrogen atom or a methyl group; W represents a linear alkylene group having from 1 to 10 carbon atoms, a branched alkylene group having from 3 to 10 carbon atoms or a cyclic alkylene group having from 3 to 10 carbon atoms; n represents 0 or 1; and p represents 1 or 2.)

The present invention relates to a process for converting a tertiary OH group of an organic compound into a tertiary Cl group of the organic compound by using a solvent selected from the group comprising toluene, o-xylene, m-xylene, p-xylene and mixtures thereof, and thionyl chloride as the chlorinating agent.

A process for the preparation of polyisocyanates which contain one or more biuret groups, by reacting

• a) an aliphatic or cycloaliphatic isocyanate containing two or more isocyanate groups (isocyanate a) with
• b) a tertiary alcohol or a mixture of water and a tertiary alcohol (biuretizing agent b)

at from 100 to 250° C., which comprises carrying out the reaction in the presence

c) of a stabilizer (c) which constitutes a catalytic amount of urea, ammonia, biuret, a urea derivative of the formula I

in which R¹, R², R³ and R⁴ are hydrogen, C₁ to C₁₀ alkyl or C₅ to C₁₀ aryl, or

a carboxamide of the formula II

in which R⁵ is C₁ to C₁₂ alkyl which is unsubstituted or in which 1, 2 or 3 hydrogen atoms are replaced by a radical

This invention relates to synthetic method of a ( E, E) - geranyl linalool. The invention takes (E) - nerolidol as raw material. The hydroxyl is shield by dihydropyrane, gain ( E) - nerolidol tetrahydropyrane aether; selenium dioxide and teri-butyl hydroperoxide selectively oxidize the anti-form methyl of ( E) - nerolidol tetrahydropyrane aether to gain anti-form allyl position hydroxylated oxidative product ( E, E) - 12 - hydroxy nerolidol tetrahydropyrane aether, transit halogenating reaction to gain ( E, E) - 12 - halogeno- nerolidol tetrahydropyrane aether, then take reaction with isopropyl methyl ketone that is selectively divested one proton by diisopropyl amido lithium, generate ( 6E, 10E) - 2, 6, 10, 14 - tetramethyl - 14 - ( tetrahydropyrane - 2 - oxygen) -16 - 6, 10, 15 - triene - 3 - ketone, use sodium borohydride to reduce to gain ( 6E, 10E) - 2, 6, 10, 14 - tetramethyl - 14 - ( tetrahydropyrane - 2 - oxygen) -16 - 6, 10, 15 - triene - 3 - alcohol, takes reaction with sulfonyl chloride or sulphonic acid ester with alkali presence to gain ( 6E, 10E) - 2, 6, 10, 14 - tetramethyl - 14 - ( tetrahydropyrane - 2 oxygen) -16 - 6, 10, 15 - triene - 3 - alcoholic sulphonic acid ester, then divide sulphonic acid ester group under base catalysis to gain ( E, E) - geranyl linalool tetrahydropyrane aether, and by deprotection to gain ( E, E) - geranyl linalool. ˕For the configuration of ( E) - nerolidol 3 position tertiary carbon is not influenced in the course of reaction, if use ( E) - nerolidol that has optical activity as raw material, should gain optical active ( E, E) - geranyl linalool. ((E, E)-geranyl linalool can replace Teprenone and such type medicament intermediate, natural product intermediate, insect pheromone and spice etc.

The invention relates to a method for producing polymethacrylimides in two steps: 1) radical copolymerization of (meth)acrylamides (A, (Me,H)HC=CHCONHR2) and alkyl(meth)acrylic esters (B) and optionally further ethylenically unsaturated monomers in the presence of an aqueous solvent. The monomers (A) include, in addition to acrylamide and methacrylamide, (meth)acrylamides that are substituted on their nitrogen group (R2<>H). The monomers (B) are the (meth)acrylic esters of secondary or tertiary alcohols, preferably tert. butylmethacrylate. 2) Thermal or catalytic reaction of the copolymers produced in 1) to polymethacrylimide or for R2<>H to N-substituted polymethacrylimides while alkenes are separated.

The invention relates to a 25-hydroxy vitamin D2 series medicament side chain and its preparation method. The invention provides a novel compound 1, the structure of which is shown in formula 1, and a synthetic method thereof. The synthetic method provided by the invention comprises the following steps of: using (S)-2-methyl-3-hydroxypropionic acid methyl ester as an initial raw material, performing a reaction between (S)-2-methyl-3-hydroxypropionic acid methyl ester and a methyl metal reagent, carrying out selective halogenation or sulfonate esterification, followed by selective halogenation and protection of tertiary alcohols, and performing a reaction with a metallic compound of diaryl phosphine or trialkoxyl phosphine to obtain the target compound.

The invention discloses a preparation method and application of a chiral tertiary alcohol or tertiary ether compound. A racemase 4-substituted-4-vinyl-1,3-dioxolan-2-one compound is used as a raw material, and under the catalysis of a palladium coordination compound, which is generated under a palladium source and the coordination action of a chiral ligand, and a boron compound which serve as catalysts, reacts with water or alcohol to prepare the chiral tertiary alcohol or tertiary ether compound. The chiral compound provided by the invention is the multi-functionalized chiral tertiary alcohol or tertiary ether compound, can be used for flexibly and conveniently carrying out functional conversion, is about to be an important chiral molecular building block for preparing a chiral drug and an intermediate. The preparation method provided by the invention comprises asymmetric hydroxylation and etherification reactions co-catalyzed by palladium and boron; the preparation method is high in catalytic activity, high in regioselectivity and enantioselectivity and mild in reaction condition; reactive raw materials are conveniently and easily obtained.

This invention relates to a synthesis method for alpha-olefinic bond-functionalized cyclic carbonates from alpha-alkynyl tertiary alcohols and carbon dioxide. In this method, ionic liquids which consist of alkylpyridines or 1,3-dialkylimidazole cations and inorganic or organic anions and have a liquid state at room temperature are adopted as reaction media, univalent or bivalent copper salts are adopted as catalysts; and alpha-alkynyl tertiary alcohols and carbon dioxide are catalyzed to react with each other at a pressure of 0.1~2.0MPa and a temperature of 40~180 deg.C for 1~20 hours so as to produce alpha-olefinic bond-functionalized cyclic carbonates. It is characteristics of this method that no more organic solvents or organic bases are needed, and compared to conventional catalytic process; it has the advantages of low carbon dioxide pressure, high reaction rate, high product purity and reusability of ionic liquids and is thus pretty promising for industrial application.

The invention relates to a polymetallic cyanide complex catalyst for ring opening polymerization of oxyalkylene, mainly aiming at resolving the problems existing in the prior technique that the activity of a catalyst is not enough and the catalyst needs relatively long induction period to acquire higher activity. In the invention, the technical proposal which better resolves the problems is as follows: the catalyst comprises one or a plurality of metallic cyanide complexes, a C4 to C10 organic alcohol with an tertiary alcohol structure and an organic ligand selected from aliphatic ester, aromatic monoester or aromatic diester and a mixture of the aromatic monoester and the aromatic diester. The catalyst has the advantages of no induction period and high activity, and is applied to the industrial preparation of unsaturated polyether polyols by the ring opening polymerization of the oxyalkylene.

The present invention relates to one kind of double-metal cyanide catalyst and aims at solving the problem of catalyst with longer induction period. The catalyst includes double-metal cyanide mixture, organic C4-C10 alcohol with tertiary alcohol structure and organic ester selected from fatty ester, aromatic monoester, aromatic biester and their mixture. It may be used in the industrial production of low unsaturation degree polyether polyol.

A fluorinated polyvalent carbonyl compound is produced by an economically advantageous method from inexpensive materials without requiring a complicated synthetic process step. Namely, the present invention comprises reacting a polyvalent alcohol having at least two kinds of alcohol skeletons selected among a primary alcohol, a secondary alcohol and a tertiary alcohol, with an acid halide to obtain a polyvalent ester compound, fluorinating it in a liquid phase to obtain a perfluorinated polyvalent ester compound, and cleaving the ester bonds derived from primary and secondary alcohols in the perfluoropolyvalent ester compound to obtain a fluorinated polyvalent carbonyl compound.

A method for producing high reactive polybutene (HRPB), in which carbon-carbon double bond is positioned at an end of polybutene, is disclosed. The high reactive polybutene having 300˜5000 of number average molecular weight (Mn) can be produced from a raw material containing isobutene, wherein a polymerization reaction of the isobutene is carried out in the presence of a catalyst system including secondary alkylether, tertiary alcohol, and boron trifluoride, the amount of boron trifluoride is 0.05˜1.0 weight part per 100 weight part of isobutene, the mole ratio of a co-catalyst including secondary alkylether and tertiary alcohol:boron trifluoride is 1.0˜2.0:1, and the mole ratio of secondary alkylether:tertiary alcohol is 0.5˜1.2:1.

The invention discloses a carboprost 15-site isomer impurity separation technical method, and belongs to the technical field of pharmaceutical chemical separation. The method comprises the steps: carrying out PG protection on the compound B with the 15-site hydroxyl tertiary alcohol to obtain 15-site S-type carboprost D and 15-site R-type carboprost E (forming the 15-site hydroxyl tertiary alcohol compound C), and separating to obtain a pure product of the 15-site carboprost D or the 15-site carboprost E. On the basis, the invention also provides a method for preparing the carboprost series products, wherein the method is suitable for industrial amplification. According to the method, after proper protecting group derivation, the isomer can be separated by adopting common silica gel column chromatography, the operation is simple, the quality of the obtained product meets the requirement, the production cost is greatly reduced, and the comprehensive benefit of the product is improved.

The invention discloses a chiral phosphoric acid catalyzed allyl tertiary alcohol kinetic resolution method.In the presence of an organic solvent and an additive, an (E)-alkenyl substituted diol compound shown in a formula I is subjected to a kinetic resolution reaction under the catalysis of a chiral phosphoric acid catalyst shown in a formula II to obtain achiral allyl tertiary alcohol (E)-alkenyl substituted diol derivative as shown in a formula III and an (E)-2-alkenyl substituted tetrahydrofuran compound as shown in a formula IV, and the reaction formula is shown as the specification. The method utilizes the chiral phosphoric acid as the catalyst, the (E)-alkenyl substituted diol compound with good functional group compatibility and stable properties is used as a substrate, and various chiral allyl tertiary alcohol (E)-alkenyl substituted diol derivatives and (E)-2-alkenyl substituted tetrahydrofuran compounds are efficiently prepared under the action of a single additive. According to the preparation method, the substrate application range is wide, the reaction conditions are simple, the obtained two products with high optical activity can be further converted into multiple natural products and important intermediates of medicine, and high application value is achieved.