44 results about "Tertiary alcohols" patented technology

The present disclosure is directed to UstD mutants capable of producing non-canonical amino acids that contain secondary or tertiary alcohols at the gamma position, and methods of using the mutants to produce the non-canonical amino acids. The mutants can use aldehyde-containing substrates and ketone-containing substrates to generate the secondary and tertiary alcohol groups, respectively.

The invention discloses a method and a device for preparing a D-A type thermally activated delayed fluorescent material through continuous flow. A two-section type continuous flow reaction system is adopted, wherein the first continuous flow reaction system is connected with a tubular reactor in series through a micro-channel reactor, and efficient nucleophilic substitution reaction of an electron acceptor halide and an electron donor is achieved under palladium catalysis; the second continuous flow reaction system is driven by double feeding pumps, so that a D-A type compound prepared from a precursor and nonaphenyl tertiary alcohol are subjected to Friedel-Crafts alkylation modification under the catalysis of acid, the reaction time of the two steps is greatly shortened, and the yields of the two steps are both 88% or above. Through flow rate limitation, solvent concentration, solid content and temperature-pressure cooperative control, the problems of palladium-containing catalyst slurry transmission and side reaction inhibition are solved. According to the method, continuous kilogram-level production of the TADF material is achieved, compared with a traditional process, energy consumption is reduced, intermediate separation is not needed, and a new normal form is provided for industrial preparation of the OLED material.

The application discloses an acid-responsive fluorescent sensing material and a preparation method and application thereof. The acid-responsive fluorescent sensing material can detect strong acid in a liquid environment. The structure of the acid-responsive fluorescent sensing material is as follows: the group responding to acid of the material is a hydroxyl group of a tertiary alcohol, and the hydroxyl group is removed under the action of acid to change the fluorescence intensity. Different molar amounts of strong acid can be distinguished by different fluorescence intensities in various liquid environments. The fluorescent sensing material prepared by the application can detect acid. After the fluorescent sensing material is mixed with acid, the color of the solution can be obviously observed to change. The change of the fluorescence signal under an ultraviolet lamp can be observed by naked eyes. The visual detection of strong acid is realized. The response speed and accuracy of the acid are improved. The fluorescent sensing material has good reusability. The acid-responsive fluorescent sensing material has the advantages of simple synthesis method, convenient separation and purification, high yield and good stability, and therefore has certain application value in the field of intelligent sensors.

The disclosed and claimed subject matter relates to formulations comprising a combination of (i) one or more alkynes and (ii) one or more tertiary alcohols and their use for enhancing passivation of metal substrates.

The invention belongs to the technical field of organic synthesis, and discloses a diastereoselective synthesis method and application of polysubstituted cyclobutane. The preparation method comprises the following steps: adding 3-methylene cyclobutyl tertiary alcohol, alkyl halide (or acyl and sulfonyl halide) and a photocatalyst into an organic solvent, and reacting in a nitrogen atmosphere and under the irradiation of a blue light LED lamp to generate cis-1, 3-bifunctional cyclobutane with a single configuration. The photocatalyst used in the method does not contain metal and is small in dosage, wide in substrate range and high in stereoselectivity. In addition, according to the invention, the product is successfully subjected to a one-step cyclization reaction under the action of alkali to generate polysubstituted bicyclo [2.1. 1] hexane. According to the application, heteroaryl with various structures is successfully introduced to bridgehead carbon of bicyclo [2.1. 1] hexane, and functional groups such as cyano groups and aldehyde groups which are easy to modify and convert as well as bromine atoms and fluorine atoms which are difficult to introduce in a traditional method are also introduced. The synthesis method has the advantages of high efficiency, simplicity, wide substrate universality, good functional group compatibility and the like.

The present disclosure relates to a process for the preparation of a tertiary alkyl organic peroxide comprising: a) reacting in a first condensation stage a component comprising at least one tertiary alcohol group with a compound comprising at least one tertiary hydroperoxide function in the presence of a catalyst and optionally a co-catalyst, b) separating the aqueous phase from the organic phase in a dehydration stage, and c) separating the aqueous phase from the organic phase in a second condensation stage in the presence of a catalyst and optionally a co-catalyst to form a mixture comprising an organic phase and an aqueous phase, the organic phase comprising a tertiary alkyl organic peroxide. The component containing at least one tertiary alcohol group is further reacted with the compound containing at least one tertiary hydroperoxide group, the molar ratio between the compound containing at least one tertiary hydroperoxide functional group and the component containing at least one tertiary alcohol group being at least 3: 1 in the first condensation stage, and the molar ratio between the compound containing at least one tertiary hydroperoxide functional group and the component containing at least one tertiary alcohol group being at least 2: 1 in the second condensation stage. And wherein dehydration does not occur during the first condensation stage.

The invention belongs to the technical field of organic synthesis, and particularly relates to a universal selective co-production method of monosubstituted alkynyl tertiary alcohol, which comprises the following steps: 1) adding alkali and an organic solvent into a reaction container, replacing air in the reaction container with acetylene gas, and continuously introducing the acetylene gas into the reaction container to keep the acetylene pressure in the reaction container at 0.10-0.25 MPa; 2) stirring and heating to 20-80 DEG C, dropwise adding ketone into the reaction container, and carrying out heat preservation reaction until the reaction is finished; and 3) quenching the reaction liquid, taking an organic phase material, washing, drying, and carrying out rotary evaporation concentration to obtain the target product. Acetylene and ketone are used as raw materials for co-production of the monosubstituted alkynol and the disubstituted alkynol, the yield of the monosubstituted alkynol can reach 24.86% at most, and the method is suitable for various ketone compounds and has good universality, and the process is simple to operate and easy to industrially popularize.

The electrochemical energy conversion system of the present disclosure includes an anode, a cathode, and an ion exchange membrane including a polymer having an aromatic polymer chain and an alkylated substrate including an alkyl chain, and at least one ionic group. The alkylated substrate is bound to at least one aromatic group in the polymer chain via Friedel-Crafts alkylation of the at least one aromatic group. The alkylation reaction utilizes a haloalkylated tertiary alcohol or a haloalkylated alkene as a precursor. In the presence of an acid catalyst, a carbocation is generated in the precursor which reacts with the aromatic rings of the polymer chain. The at least one ionic group is then replaced with a desired cationic or anionic group using a substitution reaction. The membranes exhibit advantageous stability achieved through a simplified and scalable reaction scheme.

The purpose of the present invention is to provide a means for imparting adhesiveness to nails without sanding.　The present invention is a primer coat resin composition for nails, the composition containing components (A) and (B) but being free of a photo-radical initiator.　Component (A) is at least one selected from the group consisting of secondary alcohols having a molecular weight of at least 145 and a (meth)acryloyl group and tertiary alcohols having a molecular weight of at least 145 and having a (meth)acryloyl group (excluding component (B)). Component (B) is a phosphoric acid ester compound having a (meth)acryloyl group.

A dual-use coolant includes a fluid. The fluid has the chemical formula of a tertiary alcohol with a R1, a R2, and a R3 group having the following formula (I). The coolant may also be used as a base fluid for a lubricant. The use of a single fluid for both lubrication and cooling may decrease the complexity, weight, and manufacturing costs of the associated system.

The present invention relates to a method for synthesizing 3-amino-2-cyclohexene-1-one and its salts. Specifically, a diol is used as the solvent of the reaction system, and 5-oxohexanenitrile is used as the raw material. A cyclization reaction occurs under the action of a base. The diol is preferably a pinacol-type di-tert-alcohol (such as 3,4-dimethylhexane-3,4-diol, 2,3-dimethyl-2,3-butanediol, 3,4-diethyl-3,4-hexanediol, etc.), more preferably R1 = R2 = R3 = R4 (such as 2,3-dimethyl-2,3-butanediol, 3,4-diethyl-3,4-hexanediol, 1,1,2,2-tetraphenylethane-1,2-diol, etc.), and even more preferably 2,3-dimethyl-2,3-butanediol (R1 = R2 = R3 = R4 = CH3).

N-Biarylmethylene substituted pyrrolopyridinone, pyrrolopyrazinone, pyrrolopyrimidinone, and isoindolin-1-one compounds having a tertiary alcohol-containing group substituted on the biarylmethylene are positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChRM1). The compounds and pharmaceutical compositions may be used in treating neurological disorders, psychiatric disorders, or a combination thereof.

The present application provides a demercaptan agent consisting of: (1) at least one aminocarboxylate salt containing a primary amine group, a secondary amine group or a tertiary amine group, (2) at least one alcohol amine being a primary alcohol amine, a secondary alcohol amine or a tertiary alcohol amine, and (3) water. The present application also provides a preparation method and use of the demercaptan agent and a method for removing mercaptans from liquefied petroleum gas using the demercaptan agent. The demercaptan agent of the present application removes mercaptans by extraction without using inorganic bases such as sodium hydroxide, and the regenerated demercaptan agent can be regenerated by steam stripping, recycled and used, and no alkali residue is discharged. The demercaptan agent of the present application can be used for removing mercaptans from liquefied petroleum gas, and the total sulfur content of refined liquefied petroleum gas can be reduced to 5 μg·g ‑1 The following.

The invention discloses a preparation method and application of a series of novel chiral polydentate amino alcohol ligands. The synthesis method comprises the following steps: preparing primary alcohol type chiral amino alcohol by taking L-amino alcohol and 2-halogenated heteroaromatic ring as raw materials and carrying out nucleophilic substitution reaction in one step; the tertiary alcohol type chiral amino alcohol is prepared by taking L-leucine as a raw material, and sequentially carrying out methyl esterification, Buchwald-Harwig cross-coupling reaction and phenyl magnesium bromide addition reaction to synthesize the tertiary alcohol type chiral amino alcohol. The method disclosed by the invention is simple in process, mild in reaction condition, cheap and easily available in raw materials, easy in product separation and purification and high in yield; and the prepared chiral polydentate amino alcohol ligand can be applied to identification of camphorsulfonic acid enantiomers and determination of enantiomer excess (ee value).

The present invention relates to a method for production of a mixture comprising polyol(s) and amine(s) from a polyurethane, said method comprising the steps of: a) providing a starting material comprising the polyurethane, b) suspending the starting material comprising the polyurethane in a suspending agent comprising an alcohol to provide a polyurethane suspension, c) heating the polyurethane suspension to a temperature in the range of 150° C. to 400° C. to provide said mixture comprising polyol(s) and amine(s), wherein said alcohol is a C4-C8 tertiary alcohol. Another aspect involves the use of an alcohol selected from the group consisting of a C4-C12 tertiary alcohol and a C3-C10 secondary alcohol for catalysing the conversion of a polyurethane to provide polyol(s) and amine(s).

The present invention discloses a method for nickel(II)-catalyzed synthesis of chiral five-membered heterocyclic alcohol derivatives. The five-membered heterocyclic alcohol compounds are compounds with the following general formula or enantiomers and racemates of the compounds: The present invention uses inexpensive Ni(II) metal salts and BI-DIME as catalysts to catalyze the reductive cyclization reaction of alkynones. This reaction has high catalytic efficiency, high enantioselectivity and E / Z selectivity. A series of tetrahydrofuran / pyrrolidine derivatives with chiral tertiary alcohols are synthesized using this catalyst in the present invention. This method has the advantages of mild reaction conditions, low catalyst dosage and low cost, and has high application value and good prospects for popularization and application.

The application discloses a normal-temperature soaking type butter cleaning agent and a preparation method thereof, and components of the butter cleaning agent are composed of pearl alkali, a pH regulator, a chelating agent, triethanolamine, lan-826, a secondary alcohol and a tertiary alcohol polyoxyethylene ether, a heavy oil stain surface active agent AL 100 of Yingchuang, E-1308, a metal protective agent and deionized water. The product of the application adopts unique compound raw materials, has excellent emulsification and dispersion effect on butter, utilizes high content of imported pearl alkali to play a certain saponification effect, simultaneously, auxiliary chelating agents are used to chelate and separate metal ions, so that the butter stains can be cleaned under normal temperature conditions. The product of the application has strong emulsification effect and long emulsification time, can effectively shorten cleaning time, is free of corrosion to steel products, and has a protection effect on the steel products.

This invention belongs to the field of organic synthesis technology and relates to a method for preparing high-purity tertiary alcohols, comprising: (1) reacting the crude product of the compound shown in Formula I with p-nitrobenzoyl chloride; (2) recrystallizing the obtained product to obtain the compound shown in Formula II; and (3) hydrolyzing and distilling the compound shown in Formula II to obtain the pure product of the compound shown in Formula I, as shown below. The high-purity tertiary alcohol prepared by this method has a single impurity content of less than 0.1% and has been successfully applied to E-nerolidol, with a purity sufficient to meet the requirements for use as a pharmaceutical raw material. This method has high yield, low cost, and is suitable for industrial production.

The application provides a coumarin tertiary alcohol compound containing bistrifluoromethyl and a preparation method and application thereof, and belongs to the technical field of organic synthesis chemistry, and aims to solve the technical problems of single structure and poor bactericidal activity of existing trifluoro tertiary alcohol compounds.The structural formula of the coumarin tertiary alcohol compound is shown in the following formula: in the formula, R is Me, OMe, OEt, F, Cl, Br or Ph.The preparation method is as follows: a trifluoroacetyl coumarin compound, a trifluoromethyl silane compound, a catalyst and a solvent are mixed to prepare a reaction solution, the reaction solution is fully reacted, and after purification, the coumarin tertiary alcohol compound is prepared.The application widens the synthesis of bistrifluoromethyl tertiary alcohol and tertiary alcohol siloxane compound products, the compound has excellent antibacterial activity, has a good effect on more plant fungal diseases, is worth further exploration, and has a wide exploration and application space in the field of pesticides.

[Problem] To provide a method for improving the selectivity of an unsaturated aldehyde. [Solution] A method for producing an unsaturated aldehyde, which uses a catalyst including a complex oxide containing molybdenum, bismuth, iron, and cobalt, and subjects a compound selected from propylene, isobutylene, and a tertiary alcohol to catalytic gas-phase oxidation in the presence of a molecular oxygen-containing gas in a fixed-bed multi-tubular reactor, wherein the catalyst is obtained by reduction treatment followed by oxidation treatment.

Disclosed herein are methods for preparing tertiary alcohols from optionally substituted phenyl ketones or optionally substituted pyridyl ketones, the methods comprising the use of chiral ligands and boron trifluoride etherate. The tertiary alcohols can be used to prepare synthetic forms of natural products and / or drugs.

The application relates to the field of chemical synthesis, and first proposes a semi-synthetic method of a natural product Sokotrasterol sulfate. Swine deoxycholic acid is used as raw material, methyl ester and tert-butyl dimethyl silyl ether are used to protect the carboxyl and different-position hydroxyl groups of the swine deoxycholic acid; after selective oxidation of the 3-position hydroxyl group, bromination, hydrolysis, introduction of a 2-position beta-configuration hydroxyl group and borohydride oxidation-reaction introduction of an alpha-configuration hydrogen at the 5-position are carried out; then, methyl ester hydrolysis, iodination and decarboxylation are carried out to introduce iodine at the 17-position; hydrolysis and bromination are carried out on the iodine to introduce bromine at the 17-position; then, halogen-lithium exchange reaction, lithiation reaction and elimination of a tertiary alcohol are carried out to introduce a side chain at the 17-position; finally, the protective groups are removed, and the hydroxyl groups at different positions are subjected to sulfation reaction to obtain the target natural product. Through the technical scheme, the problems that the natural product is directly obtained from a marine sponge, extraction and purification are difficult, the yield is low, and the natural product cannot be effectively structurally modified are solved.

The invention relates to the technical field of asymmetric organic synthesis, in particular to a method for synthesizing a heterocyclic skeleton containing chiral tertiary alcohol through asymmetric reaction, which comprises the following steps: acquiring structural information of a substrate to be reacted and combination information of a nickel catalyst and a chiral ligand; optimizing an electronic environment of a key reaction site in the substrate to be reacted according to the combination information of the nickel catalyst and the chiral ligand, and obtaining optimized reaction activity information; controlling the selectivity of the asymmetric cyclization reaction according to the reaction activity information so as to construct a chiral tertiary alcohol heterocyclic ring containing tetra-substituted olefin; the chiral tertiary alcohol heterocyclic structure containing the tetra-substituted olefin is efficiently and highly selectively constructed, and the chiral tertiary alcohol heterocyclic structure has important application value in drug synthesis and related fields.

The invention discloses an organic amine composition for capturing CO2 in flue gas, a decarburization solvent containing the composition and a decarburization method of the decarburization solvent, the organic amine composition comprises 2, 4, 6-trisubstituent-1, 3, 5-triazinane and tertiary alcohol amine, and substituent groups are selected from alcohol groups and / or hydroxyl groups. The composition and the decarburization solvent have excellent CO2 absorption performance and CO2 desorption performance when applied to decarburization, and indexes such as CO2 absorption capacity, absorption rate, desorption efficiency and desorption energy consumption can be considered at the same time.

The application belongs to the field of organic chemical synthesis and medicinal chemistry, and particularly relates to the field of avarane type polycyclic heteroterpene compounds, and discloses that a 6 / 6 fused dienone tertiary alcohol is converted into a spiro[4.5]ene dienone skeleton through a rare stereospecific 1,2-alkyl migration reaction, de-OEt-1'-septosones B and C, 1'-septosones B and C and spiroetherones A and B are synthesized, and the structures of spiroetherones A and B are modified. Meanwhile, biological activity tests on the synthetic intermediates find that two new compounds exhibit significant anti-cancer activity on Hep G2, MV-4-11 and MOLT-4 cell lines, and IC epi values are as low as 2.1 μM. The application provides a new way and compound basis for the research and application of related heteroterpene compounds. epi values are as low as 2.1 μM. The application provides a new way and compound basis for the research and application of related heteroterpene compounds. 50 values are as low as 2.1 μM. The application provides a new way and compound basis for the research and application of related heteroterpene compounds.

The invention relates to a method for preparing a 1, 4-dicarbonyl compound containing heteroaromatic ring. Specifically, under the condition of catalysis of a photosensitizer fac-Ir (ppy) 3, aromatic heterocycle substituted tertiary alcohol, carbon monoxide and a diazo compound are prepared through a one-pot method. According to the invention, starting from simple and easily available raw materials and catalyst, a series of heteroaromatic ring-containing 1, 4-dicarbonyl compounds are obtained through carbonylation reaction.

The invention provides a novel method for realizing conversion from tertiary alcohol to ester in one step through carbon-carbon bond oxidative cleavage. According to the method, the ester compound is prepared from the tertiary alcohol compound by reacting for 12-48 hours at 110-180 DEG C in the presence of a nitrate catalyst in an oxygen atmosphere, and the method has the following advantages: 1) the application range of a substrate is wide, and the yield of medium or above can be obtained; and 2) the method does not need additional addition of an initiator, an oxidant and the like, and has the advantages of simplicity in operation, high stability, capability of realizing gram-level scale amplification and the like. And 3) the method can realize functional group conversion of complex bioactive molecules.

The invention belongs to the technical field of organic chemical synthesis, discloses a method for synthesizing a photocatalytic carboxylic acid compound, and relates to a method for synthesizing the photocatalytic carboxylic acid compound by converting cheap and easily available alkyl alcohol as a raw material, potassium tert-butoxide and carbon disulfide into a stable xanthate compound without complex post-treatment under the catalysis of a cheap and easily available organic photocatalyst through a one-pot method. Under the excitation of visible light, deoxidation Giese reaction with organic phosphine is carried out to generate alkyl free radicals, and then alkyl carboxylation reaction with olefin and CO2 is carried out to generate a series of alkyl carboxylic acid derivatives. Compared with a traditional synthesis method that primary alkyl free radicals are unstable and a method for synthesizing carboxylic acid compounds through addition of the primary alkyl free radicals and olefin has limitation, the method provided by the invention makes up the limitation. The high-efficiency deoxidation reaction of primary, secondary and tertiary alcohols with different functions and structures is used for generating corresponding primary, secondary and tertiary alkyl free radicals, so that the reaction of preparing the carboxylic acid compound by alkyl carboxylation of the primary, secondary and tertiary alkyl free radicals and olefin is realized.

The present invention discloses a polymerizable compound, a liquid crystal composition comprising the polymerizable compound, and a liquid crystal display device. The polymerizable compound is a compound represented by the following formula I, wherein Sp represents a single bond or a C1-C5 linear, branched or cyclic alkyl group, and the Sp groups are not both single bonds, wherein any one or more non-adjacent —CH2— can be replaced by —O—, —S—, —CO—, —CH2O—, —OCH2—, —COO—, —OOC—, or an acrylate group in such a manner that O- or S-atoms are not directly connected with each other, one or more H atoms can be independently replaced by F, C1, or G3, and at least one H atom is replaced by G3; G3 represents a C1-C7 tertiary alcohol structure; and X represents —CH2—, —O—, or —S—. In particular, the polymerizable compound has the advantages of good diffusivity, high stability of the formed polymer, and low residue after a UV process. It can be ensured that a display exhibits excellent IS performance under extreme conditions.

The present invention relates to a process for preparing a polyfluorinated alcohol of formula (I) from a ketone of formula (II) and a carboxylic acid salt of formula (III) (R3COO) xY wherein the substituents R1 and R2 are selected from the group consisting of C1-C10 alkyl, C3-C10 cycloalkyl, C6-C14 aryl and C5-C14 heteroaryl wherein the substituents may be unsubstituted or partially or fully fluorinated; r3 is a C1 to C10 alkyl group, which is partially or fully fluorinated; y is a cation selected from the group consisting of K, Li, Na, Cs, Mg, Ca, Fe, Cu, Ag, Zn; x is 1 or 2. In the method, the R3 group of the carboxylate is transferred to the carbonyl carbon of the ketone of formula (II) while releasing CO2. # imgabs0 #