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Set of endometrial receptivity biomarker, kit and method for judging endometrial receptivity

A biomarker and endometrium technology, applied in biochemical equipment and methods, microbial measurement/testing, bioinformatics, etc., can solve endometrial cell adhesion dysfunction and affect endometrial receptivity And other issues

Pending Publication Date: 2021-03-09
深圳市锦欣医疗科技创新中心有限公司 +1
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  • Claims
  • Application Information

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Problems solved by technology

If the abnormal expression of cell adhesion-related biomarkers is detected in the patient's multiple biomarkers, it indicates that the cell adhesion function of the patient's endometrium may be abnormal, thereby affecting its endometrial receptivity

Method used

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  • Set of endometrial receptivity biomarker, kit and method for judging endometrial receptivity
  • Set of endometrial receptivity biomarker, kit and method for judging endometrial receptivity
  • Set of endometrial receptivity biomarker, kit and method for judging endometrial receptivity

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Experimental program
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Embodiment

[0091] This embodiment is a method for screening a group of biomarkers of PCOS endometrial receptivity of the present invention, and the specific steps are as follows:

[0092] Step 1: Collect Samples

[0093] Intrauterine scraping of the endometrium in the mid-luteal phase of infertile patients, including the following:

[0094] On the 7th-9th day of the patient's luteal phase (LH), use a disposable endometrial sampling tube to sample the endometrium. The specific sampling steps are:

[0095] Washing and disinfection: wash the vulva with 0.1% Anduofu, and wash the vagina twice;

[0096] Putting the speculum: Put the speculum into the vagina in a closed manner, then open the speculum to expose the cervix and fix it;

[0097] Sampling: Put the sampling tube into the uterine cavity from the cervix, adjust the angle according to the position of the patient's uterus, pull the needle core of the sampling tube outward to the position of the cervix after reaching the fundus, and pu...

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Abstract

The invention relates to a set of endometrial receptivity biomarkers, a kit and a method for judging endometrial receptivity. The biomarkers can provide an efficient, rapid, high-specificity and high-sensitivity detection and evaluation means for early discovery and diagnosis, targeted intervention and embryo transplantation guidance of PCOS infertility patients. The kit for detecting the PCOS endometrial receptivity contains the endometrial receptivity markers and can provide an efficient, rapid, high-specificity and high-sensitivity detection and evaluation means for early discovery and diagnosis of the PCOS infertility patients.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a group of endometrial receptivity biomarkers, a kit and a method for judging endometrial receptivity. Background technique [0002] Polycystic ovary syndrome (PCOS) is a common endocrine disorder syndrome in which reproductive dysfunction and abnormal glucose metabolism coexist in women of childbearing age. It is the main cause of anovulatory infertility, and its endometrium Abnormal status is another important factor leading to infertility, and it is also one of the main reasons why PCOS infertility treatment is difficult. [0003] PCOS is jointly affected by related factors such as environment and genetics. Excessive androgen, menstrual disorders, and ovulation disorders are important features of PCOS, and there is great heterogeneity in its clinical manifestations and pathogenesis. Obesity is a major factor leading to infertility. Most obese women have infertility related to abn...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883G16B25/00G16B20/30G16B20/50G16B30/10
CPCC12Q1/6883G16B25/00G16B20/30G16B20/50G16B30/10C12Q2600/158
Inventor 刘苏洪玲肖珊刁梁辉王雪金魏红霞
Owner 深圳市锦欣医疗科技创新中心有限公司
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