Polyhydroxy stilbenes compound preparation and uses as drugs for suppressing SARS

A polyhydroxy stilbene and compound technology, which is applied in the preparation of polyhydroxy stilbene compounds and the use of SARS virus-inhibiting drugs, can solve the problems of not detecting that SARS-CoV has an effect and the like
CN1736986AInactive Publication Date: 2006-02-22DALIAN UNIV OF TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
DALIAN UNIV OF TECH
Publication Date
2006-02-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a group of polyhydroxy stilbene compounds, their preparing process and use for suppressing and eradicating SARS coronavirus. The preparing process comprises, preparing phosphonic ester by reacting multi-alkyl substituted chloro (bromo) methoxyl or pyridine compounds with triethyl phosphate, then reacting phosphonate ester compound with multi-alkyl (oxy) phenylpyridine methyl aldehyde to obtain multi-alkyl (oxy) stilbene compounds. Finally acting with boron tribromide to obtain polyhydroxy stilbene compounds with substituent groups.
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Description

technical field

[0001] The invention relates to a new class of medicinal polyhydroxystilbene compounds, a preparation method and application thereof. This new compound is used for inhibiting and killing SARS coronavirus. Background technique

[0002] Stilbene compounds are a general term for a class of compounds with a stilbene core. In nature, polyhydroxystilbene compounds exist in many Chinese herbal medicines such as veratrum, rhubarb, tiger stick, and Shouwu, and are neutralized in foods such as grapes, peanuts, and mulberries. , Improving immunity and many other physiological activities.

[0003] In WO 02 / 057219 patent, a class of stilbene compounds are disclosed as regulators of T cells, neutrophils, macrophages and corresponding cytokines for the treatment of immune, inflammatory and autoimmune diseases. In the structure disclosed in the WO02 / 057219 patent, only one benzene ring contains alkoxy or hydroxyl substituents at the 3 and 5 positions, the other benzene ri...

Claims

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