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Use of citronella plant extract as an insulin-sensitizing drug

A technology of insulin sensitization and citronella, which is applied in the field of use of citronella plant extracts as insulin sensitization drugs, and can solve the problems of lack of compounds and the like

Active Publication Date: 2019-12-13
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that leaves and roots contain insulin-like substances, which are off-white, odorless and slightly bitter powder, not alkaloids or glycosides, nor tannins; its insulin potency is: oral administration of 1g is equivalent to 440 units, and subcutaneous injection is equivalent to 880 units. unit [Liu Yongmin, Shawuti. Yin Kemu, Uyghur Pharmaceutical Journal (Volume 1), Xinjiang People's Publishing House, Urumqi, Xinjiang, 1986: 320], but there is no report on the structure of this compound so far

Method used

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  • Use of citronella plant extract as an insulin-sensitizing drug
  • Use of citronella plant extract as an insulin-sensitizing drug
  • Use of citronella plant extract as an insulin-sensitizing drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1. Aqueous Extract of Citronella (Cymbopogon Citratus)

[0061] Citronella (Cymbopogon Citratus) aerial part 500g, heat reflux with 5000ml distilled water, extract three times (5000ml / time), extract 1-1.5 hours each time, extract 140.0g water extract after concentrating under reduced pressure, dissolve in 500ml Add ethanol to water until the alcohol content reaches 70% (volume ratio), precipitate, filter, and concentrate the filtrate to dryness to obtain 85.0 g of a yellow powdery solid (CC-S).

Embodiment 2

[0062] Example 2. Rue (Cymbopogon distans (Nees) Wats.) water extract

[0063] Rue herb (Cymbopogon distans (Nees) Wats.) whole plant 1000g, heat reflux with 5000ml of distilled water, extract three times (5000ml / time), extract 1.5-2.0 hours each time, extract under reduced pressure and concentrate to get water extract 215.0 g, dissolved in 1000ml of water, add ethanol until the alcohol content reaches 70% (volume ratio), precipitate, filter, and concentrate the filtrate to dryness to obtain 155.0g of yellow powdery solid (CD-S).

Embodiment 3

[0064] Example 3. Aqueous extract of Cymbopogon caesius (Nees) Stapf

[0065]Green Lemongrass (Cymbopogon caesius (Nees) Stapf) leaves 500g, heat reflux with 2500ml of distilled water, extract three times (2500ml / time), extract for 1.5-2.0 hours each time, extract under reduced pressure and concentrate to obtain 120.0g of water extract , dissolved in 500ml of water, add ethanol until the alcohol content reaches 70% (volume ratio), precipitate, filter, and concentrate the filtrate to dryness to obtain 60.0g of yellow powdery solid (QCC-S).

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Abstract

The invention discloses an extractive which is extracted from a Cymbopogon plant and is capable of being used as an insulin sensitizing medicine, a preparation method of the extractive, a medicine composition which contains the Cymbopogon plant or the extractive and an application of the Cymbopogon plant or the extractive and the medicine composition thereof as a medicine. The extractive disclosed by the invention can be used as the insulin sensitizing medicine and a health care product especially.

Description

technical field [0001] The present invention relates to an extract extracted from citronella (Cymbopogon) which can be used as an insulin-sensitizing drug, a preparation method of the extract, a pharmaceutical composition containing citronella (Cymbopogon) or the extract of the genus, And the citronella plant (Cymbopogon) or the extract of the genus and the pharmaceutical composition thereof can be used as medicine, especially can be used as insulin-sensitizing medicine and health care product. Background technique [0002] Diabetes mellitus is a group of chronic metabolic disorder syndromes characterized by persistent high blood sugar [Xiang Hongding, Diabetes Epidemiology, Diagnosis and Typing and Principles of Prevention and Treatment, Chinese Medical Information Herald, 2004, 19(5): 18-18.]. Caused by relative or absolute deficiency of insulin and decreased sensitivity of target tissues to insulin (insulin resistance), resulting from a combination of genetic and environ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P5/50
Inventor 吉腾飞叶菲苏亚伦田金英王爱国杨建波张晓琳张孟孟杨晓萌王丽
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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