Application of flax root total flavone in preparing medicament for preventing and/or treating hepatitis

A technology of total flavonoids and flax, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc.

Inactive Publication Date: 2008-01-23
龙井民康生物制品厂 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although the literature records that flax root can also be used medicinally, the actual situation of comprehensive utilization of flax is still to treat flax root as waste
Relevant scientific research, especially the specific medicinal value of flax root, has not seen any formal research reports so far

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of embodiment 1 flax root total flavonoids

[0037] 200 kg of flax (Linum usitatissimum L.) roots were extracted three times with 85% ethanol under reflux, the extracts were combined, and the ethanol was recovered under reduced pressure to obtain a crude extract.

[0038] The crude extract was dissolved in water, then extracted three times with ethyl acetate of the same volume as water, and the ethyl acetate portion was discarded.

[0039] The aqueous layer was extracted three times with the same volume of n-butanol; the n-butanol layers were combined.

[0040] The n-butanol extract was first extracted three times with the same volume of 5% aqueous sodium bicarbonate solution, and then extracted with water until neutral.

[0041] The solvent is recovered under reduced pressure to obtain the n-butanol extract, and the flax root n-butanol extract is obtained, and a yellow precipitate is precipitated, and filtered to obtain the total flavonoids of the flax...

Embodiment 2

[0042] Embodiment 2, study on the acute toxicity of flax root total flavonoids

[0043] (1) Test animals

[0044] Kunming mice, male, weighing 18-22 grams, provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences, certificate number: SCDK (Beijing) 2004-0001

[0045] (2) Test drugs

[0046] Total flavonoids of flax root, yellow powder, stored in the dark at 2-5°C, provided by Professor Qin Hailin of our institute, prepared into 250mg / ml suspension with 0.5% CMC-Na.

[0047] (3) Test method

[0048] 10 mice were orally administered total flax root flavonoids at a concentration of 250 mg / ml, and each mouse was gavaged with a volume of 1.0 ml (ie the highest concentration and maximum gavage volume). Within 7 days after administration, the signs and death of the mice were observed.

[0049] (4) Test results

[0050] After oral administration of flax root total flavonoids in mice, the signs did not change significantly. No deaths occurred.

[00...

Embodiment 3

[0053] Example 3, the effect of flax root total flavonoids on ConA-induced acute liver injury in mice

[0054] (1) Test animals

[0055] Kunming mice, male, weighing 18-22 grams, provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences, certificate number: SCDK (Beijing) 2004-0001

[0056] (2) Test drugs

[0057] Total flavonoids of flax root, yellow powder, stored in the dark at 2-5°C, provided by Professor Qin Hailin of our institute, prepared into 250mg / ml suspension with 0.5% CMC-Na.

[0058] (3) Positive control drug

[0059] Bicyclol, white powder, provided by Peking Union Medical College Pharmaceutical Factory, batch number 20030801, suspended with 0.5% CMC-Na when used.

[0060] (4) Test method

[0061] The animals were randomly divided into 6 groups, 7 animals in each group, which were normal control group, ConA model group, high-dose total flax root flavonoids administration group, medium-dose flax root total flavonoids administratio...

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PUM

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Abstract

The invention discloses a Linum usitatissimum L. flavonid, the preparation method of the Linum usitatissimum L. flavonid comprising medicine assembly of the Linum usitatissimum L. flavonid and health products as well as the application of the Linum usitatissimum L. flavonid in medici8nes and health products for preparing, defending and / or curing hepatitis.

Description

technical field [0001] The invention discloses a total flax (Linum usitatissimum L.) root flavonoids, a preparation method of the flax root total flavonoids, a pharmaceutical composition and a health care product containing the flax root total flavonoids, and the flax root total flavonoids in the preparation Application in drugs and health products for preventing and / or treating hepatitis. Background technique [0002] Flax (Linum usitatissimum L.) is a plant of the genus Linaceae, which is widely distributed all over the country. The plant is an annual herb with smooth stems and a plant height of 0.75-1.20m. There are branches at the top, which are umbrella-shaped; the cross-section of the stem is round and gray-green; the flax leaves are gray-green, alternate, with linear lanceolate edges, dense leaves, flat surface, 2-3.5cm long, 22cm wide ~4cm, the base of the leaf gradually narrows, blue-green; flowers are scattered on the top of the pedicel, the pedicel is erect, 2-7...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/55A61P1/16A61K125/00
Inventor 秦海林母海成李志宏张霞王鹏刘波
Owner 龙井民康生物制品厂
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