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31 results about "Complement Factor D" patented technology

A serum protein which is important in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY. This enzyme cleaves the COMPLEMENT C3B-bound COMPLEMENT FACTOR B to form C3bBb which is ALTERNATIVE PATHWAY C3 CONVERTASE.

Treatment of age-related macular degeneration using inhibitors of complement factor d

InactiveUS20080269318A1Avoid developmentInhibit the loss of visual acuityBiocideSenses disorderComplement Factor H GeneFactor ii
The present invention provides methods for identifying a patient at risk for developing AMD by identifying the presence of the Y402H polymorphism or other at risk variants in the complement factor H gene. The present invention further provides methods for treating persons having AMD or at risk for developing AMD as a result of having the Y402H polymorphism or other at risk variants in the complement factor H gene.
Owner:ALCON RES LTD

Compounds for Treatment of Complement Mediated Disorders

ActiveUS20180022767A1Dampen and inhibit detrimental complement activitySenses disorderNervous disorderDiseaseReperfusion injury
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.
Owner:ACHILLION PHARMA INC

Amide compounds for treatment of complement mediated disorders

ActiveUS20160362398A1Dampen and inhibit detrimental complement activitySenses disorderNervous disorderDiseaseFactor D
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R12 or R13 on the A group is an amide substituent (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade in the alternative complement pathway. The inhibitors of factor D described herein reduce the excessive activation of complement.
Owner:ACHILLION PHARMA INC

Macrocyclic compounds for treatment of medical disorders

ActiveUS20200002347A1Minimal hydrolysisDecreases potential for formationOrganic chemistryAntiviralsDiseaseMedical disorder
Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
Owner:ACHILLION PHARMA INC

Evaluation Method for Arteriosclerosis

Arteriosclerosis induces cerebral infarction and myocardial infarction. A multi-marker (a group of protein markers) that assesses the accurate pathogenesis of arteriosclerosis and enables the selection of an adequate treatment method for arteriosclerosis and prediction of the progression of arteriosclerosis, and an evaluation method for the diagnosis, prevention, and treatment of arteriosclerosis that uses said marker group as an indicator have been sought. The present invention relates to A method for evaluation of arteriosclerosis comprising the steps of (a) measuring the expression of von Willebrand factor and / or complement factor D in a sample derived from a subject, (b) measuring the expression of complement component C8 and / or vitamin K-dependent protein Z in the sample derived from the subject, and (c) evaluating arteriosclerosis in the subject on the basis of the results from (a) and (b).
Owner:HITACHI LTD

Pharmaceutical compounds for treatment of medical disorders

Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
Owner:ACHILLION PHARMA INC

Macrocyclic compounds for treatment of medical disorders

ActiveUS11053253B2Decreases potential for formationReduce the possibilityOrganic chemistryAntiviralsDiseaseMedical disorder
Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
Owner:ACHILLION PHARMA INC

Compositions and methods for inhibiting factor d

ActiveUS20180051287A1Inhibit functioningOrganic active ingredientsDrug compositionsGeographic atrophyDry age-related macular degeneration
The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease.
Owner:396419 B C LTD

Pharmaceutical compounds for treatment of medical disorders

Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
Owner:ACHILLION PHARMA INC

Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.
Owner:ACHILLION PHARMA INC

Oral complement factor D inhibitors

Disclosed are compounds of Formula (I)-(IV) and pharmaceutically acceptable salts thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such compounds, and methods of using the compounds and compositions to treat or prevent diseases or conditions characterized by aberrant complement system activity.
Owner:BIOCRYST PHARM INC

Dosing regimens for oral complement factor D inhibitors

Compounds and pharmaceutically acceptable salts and prodrugs thereof are disclosed, which are inhibitors of the complement system. Also provided are oral dosage forms comprising such compounds, salts, or prodrugs. Also disclosed are methods of using the compounds, salts and prodrugs and oral dosage forms thereof to treat or prevent diseases or conditions characterized by aberrant complement system activity (e.g., paroxysmal sleep hemoglobinuria).
Owner:BIOCRYST PHARM INC

Preparation method of preeclampsia detection kit adopting Adipsin as detection index

ActiveCN102426243BQuantitative detection of accurate contentImprove accuracyDisease diagnosisChromogenic SubstratesMonoclonal antibody
A preeclampsia detecting kit using Adipsin as indicator, comprises porous plate coated with anti-human Adipsin monoclonal antibody, anti-human Adipsin monoclonal antibody detecting solution marked by biotin, avidin horseradish peroxidase combined with anti-human Adipsin monoclonal antibody marked by biotin, chromogenic substrate 3',3',5,5'-tetramethylbenzidine and Adipsin protein standard substance. The preparing method of the detecting kit comprises:(1)preparing the porous plate coated with anti-human Adipsin monoclonal antibody; (2) preparing the anti-human Adipsin monoclonal antibody detecting solution marked by biotin;(3) preparing the avidin horseradish peroxidase combined with anti-human Adipsin monoclonal antibody marked by biotin;(4) preparing the chromogenic substrate 3',3',5,5'-tetramethylbenzidine and Adipsin protein standard substance.
Owner:ORIGISSAY BIOLOGICS TECH

Method, kit, and apparatus for evaluating ischemic heart disease

It is intended to evaluate an ischemic heart disease with high accuracy by convenient operation. The method for evaluating an ischemic heart disease according to the present invention comprises the steps of: assaying complement factor H and / or complement factor D in a sample derived from the blood of a test subject; and comparing the concentration of the complement factor H and / or the concentration of the complement factor D assayed in the preceding step with a reference value(s), wherein it is determined that the seriousness of the ischemic heart disease is high when the concentration falls below the reference value.
Owner:HITACHI LTD

Stem-loop compositions and methods for inhibiting factor D

The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease. In some cases, stem-loop aptamers are provided for the inhibition of Factor D.
Owner:396419 B C LTD +1

Tool and box for quickly detecting early-stage puerperal convulsion by taking Adipsin as detection index and manufacturing method thereof

A means for rapidly detecting Adipsin for diagnosing preeclampsia comprises a water-adsorbing pad(2), a nitrocellulose membrane(5), a gold labeling pad (6) and a sampling pad (7), all of which are successively joined from the top down and fixed in the base plate(1). The gold-labeling pad (6) is partly overlapped by the sampling pad (7). A detecting line (4) coated by rabbit anti-human Adipsin polyclonal antibody, or goat anti-human Adipsin polyclonal antibody or mouse anti-human Adipsin polyclonal antibody and a controlling line (3) coated by goat anti-mouse IgG polyclonal antibody are provided on the nitrocellulose membrane (5). The detecting line (4) is located downstream and spaced from the controlling line (3).The gold-labeling pad (6) is made of water adsorbing material, and coated by gold labeled mouse anti-human Adispin monoclonal antibody. A tesk kit for rapidly detecting Adipsin for diagnosing preeclampsia comprises an outer house (8) and the said means therein. The method for preparing the said detecting means comprise: 1) coating of the detecting line (4) and the controlling line (3); 2) preparing the gold labeling pad (6); 3)combination.
Owner:ORIGISSAY BIOLOGICS TECH

Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders

Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.
Owner:ACHILLION PHARMA INC

Marker for predicting curative effect of harmful ventricular remodeling and immunotherapy of myocardial infarction patient and application of marker

The invention provides a marker for predicting the curative effect of harmful ventricular remodeling and immunotherapy of myocardial infarction patients and application of the marker. The marker comprises granular protein, galectin 3, a complement factor D, a cysteine protease inhibitor 3 and C1q, the five markers are combined to be used as serum indexes for predicting harmful ventricular remodeling and immunotherapy curative effects of myocardial infarction patients, so that the requirements on specificity, accuracy, precision (including repeatability, day difference and personnel operation error) and the like in a verification process can be met; the method has important significance in predicting harmful ventricular remodeling and immunotherapy effects of myocardial infarction patients.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV

Oral complement factor D inhibitors

Compounds of Formula (I) and pharmaceutically acceptable salts thereof are disclosed, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such compounds, and methods of using the compounds and compositions to treat or prevent diseases or conditions characterized by aberrant complement system activity.
Owner:BIOCRYST PHARM INC
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