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3 results about "Factor D" patented technology
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Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) a protein which in humans is encoded by the CFD gene. Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B.
Factor d inhibitors
The present invention relates to benzopyrazole compounds and analogs thereof. Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising a compound of Formula (I), and methods relating to the use of the compounds and compositions to treat and prevent diseases and conditions characterized by aberrant complement system activity.
Owner:BIOCRYST PHARMACEUTICALS INC
Anti-human factor d antibody constructs and uses thereof
PendingCN122122179ASenses disorderImmunoglobulins against animals/humansDiseaseAntiendomysial antibodies
The present application relates to anti-human factor D (FD) antibody constructs. The present application also provides methods of using the anti-human FD antibody constructs to treat complement-mediated diseases, pharmaceutical compositions of the anti-human FD antibody constructs, and methods of making the anti-human FD antibody constructs.
Owner:KEYUE PHARM (USA) CO LTD +1
Multi-specific constructs comprising anti-factor D moieties
The present invention provides multispecific (e.g., bispecific) constructs that target complement factor D and another complement protein (e.g., C2, C5), nucleic acids encoding such multispecific constructs, and their use for the treatment of complement mediated diseases. Also provided are novel antibody constructs that specifically recognize C5, nucleic acids encoding the antibody constructs, and uses thereof.
Owner:KEYUE PHARM (USA) CO LTD +1