The invention discloses an extraction method of lily bulb flavone and an optimization method of the extraction method. The extraction method comprises the following steps of step I, crushing lily bulbs, and performing screening; step II, weighing lily bulb powder, and adding an ethanol solution of which the concentration is 50-90%, wherein the ratio of volume of the ethanol solution to the mass ofthe lily bulb powder is (4:1) to (20:1)ml / g; step III, placing the ethanol solution in which the lily bulb powder is mixed in an ultrasonic breaker of which the water bath temperature is 20-90 DEG Cand the frequency is 100Hz, performing extraction, and after extraction, performing sucking filtration, wherein number of ultrasonic times is 1-3, and the ultrasonic time is 20-100min; and step VI, after ultrasonic extraction, performing sucking filtration, merging filtrate, and concentrating the merged filtrates with a rotation evaporimeter so as to obtain the lily bulb flavone. According to theoptimization method, ultrasonic waves are used for assisting in the extraction method, and through combination of a response surface, and systems software Design Expert, the best extraction conditionfor the total flavone in the lily bulbs is optimized. The extraction rate is increased, and the technology is stable and reliable and high in maneuverability.