Novel tablet candies capable of regulating blood pressure and preparation method thereof
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A tablet-pressed candy, a new type of technology, applied in the field of food and health care products, can solve the problems of poor stability, low content of active substances, and poor therapeutic effect, and achieve good stability, high content of active substances, and reasonable design of the preparation process Effect
Inactive Publication Date: 2018-09-18
GUANGXI UNIV OF CHINESE MEDICINE
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[0004] The invention provides a new type of compressed candy for regulating blood pressure and its preparation method, which solves the technical problems of low active substance content, poor therapeutic effect and poor stability of the compressed candy for regulating blood pressure in the prior art
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Embodiment 1
[0042] Preparation of a new type of compressed candy that regulates blood pressure
[0043] 1 Screening of Raw Material Ratio
[0044] 1.1 Extraction: Clean Cyclocarya paliurus, camellia japonica, Moringa leaves, dandelion, and kudzu root respectively, dry at 80°C for 6 hours, add 1L of water, mix well, extract 4 times, extract 2 hours each time, concentrate the filtrate, and measure the corresponding indicators . Taking the total flavonoid content and the efficacy of the extract as indicators, the types of raw materials that affect the total flavonoid content and the efficacy of the extract and the corresponding weight parts are determined through a single factor experiment method. The efficacy of the extract is expressed in terms of systolic and diastolic blood pressure in rats.
[0045] 1.2 Orthogonal experiment factor table, see Table 1.
[0046] Table 1 Raw Material Ratio - Orthogonal Experimental Factor Table
[0047]
[0048] 1.3 Taking the total flavonoid conten...
Embodiment 2
[0080] (1) Breeding of experimental animals and establishment of models: Hypertensive model rats were induced by intraperitoneal injection of nitric oxide synthase inhibitor L-NNA (dose 15 mg / (kg*d), for 3 consecutive weeks). The control group was given intraperitoneal injection of 1 mL normal saline, once a day, for 3 consecutive weeks.
[0081] (2) After the hypertensive rat model was successfully established, the rats were randomly divided into four groups: model group, extract intervention group, control group, and positive drug intervention group, with 15 rats in each group. During this period, the administration method of each group of rats is as follows:
[0082] The control group and the model group were given 2 mL of normal saline orally, once a day, for 4 consecutive weeks;
[0083] The active drug intervention group was given captopril continuously at a dose of 15 mg / (kg*d), once a day, for 4 consecutive weeks.
[0084] The extract intervention group was administe...
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Abstract
The invention provides novel tablet candies capable of regulating blood pressure and a preparation method thereof. The novel tablet candies capable of regulating blood pressure are prepared from 15-25parts by weight of cyclocarya paliurus, 35-55 parts by weight of golden camellia, 35-55 parts by weight of moringa leaves, 15-25 parts by weight of mongolian dandelion herb, 85-115 parts by weight ofkudzuvine roots, 10-30 parts by weight of glucose powder, 10-30 parts by weight of maltodextrin, 2-6 parts by weight of citric acid, 10-15 parts by weight of magnesium stearate, and 2-6 parts by weight of menthol. The preparation method of the novel tablet candies capable of regulating blood pressure comprises the following steps of carrying out extracting, carrying out concentrating, carrying out drying, carrying out tablet-compressing and so on; and the best extraction conditions are as follows: the water volume is 1.5 liters, extraction is performed for 4 times, and extraction each time isperformed for 1 hour. The novel tablet candies capable of regulating blood pressure solve the technical problems of novel blood-pressure-regulating tablet candies in the prior art, namely low contentof total flavonoids as an active ingredient, poor curative effects and so on. The preparation method of the novel tablet candies capable of regulating blood pressure is rational in experimental design; and the prepared finished products are high in total flavonoid content and good in stability. And thus, the prepared novel tablet candies capable of regulating blood pressure have improved quality,and are simple and convenient to use, safe, effective, and free of toxic and side effects.
Description
technical field [0001] The invention belongs to the technical field of food and health care products, and in particular relates to a compressed candy and a preparation method thereof, in particular to a novel compressed candy for regulating blood pressure and a preparation method thereof. Background technique [0002] Hypertension is a disease of persistent high blood pressure, which can cause stroke, heart disease, hemangioma, kidney failure and other diseases. Hypertension is a systemic disease characterized by elevated arterial pressure, which may be accompanied by functional or organic changes in the heart, blood vessels, brain, kidneys and other organs. It is divided into primary hypertension and secondary hypertension , seriously affecting people's health. [0003] Tablet sugar, also known as powder sugar or tablet sugar, is also often called soda sugar. It is a mixture of refined sugar powder as the main body, adding fillers such as milk powder and spices, and binde...
Claims
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