Modified chitosan having catechol group and biomedical material prepared from modified chitosan
A biomedical, catechol-based technology, applied in the field of chitosan, can solve the problems of high brittleness, poor water absorption, poor solubility, etc.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
example 1
[0037] 1. Select dry chitosan powder with particle size less than 400 mesh, molecular weight greater than 200,000, and degree of deacetylation greater than 85%, 50g.
[0038] 2. Dissolve the above-mentioned dry powder in a 4% acetic acid solution at 60°C, keep stirring at this temperature, stop stirring after 36 hours, and filter the insoluble matter.
[0039] 3. Dissolve 5g of dopa or 3-(3,4-dihydroxy) phenylpropionic acid in water, add helium gas, add 2 times the amount of EDC condensing agent under the protection of helium gas, adjust the pH to 6-12, React overnight to prepare EDC ester.
[0040] 4. Disperse the EDC ester prepared in step 3 into the chitosan solution prepared in step 2, adjust the pH to 4-10, stir overnight, and let stand for 24 hours.
[0041] 5. Under vigorous stirring, add glutaraldehyde dropwise to the product obtained in the previous step to control the amount of glutaraldehyde to control the degree of cross-linking at 0.1-10%.
[0042] 6. Drop the product obta...
example 2
[0044] 1. Select dry chitosan powder with particle size less than 400 mesh, molecular weight greater than 200,000, and degree of deacetylation greater than 85%, 50g.
[0045] 2. Dissolve the above dry powder in a 4% acetic acid solution at 60°C, keep the temperature and stir, stop stirring after 36 hours, and filter the insoluble matter.
[0046] 3. Dissolve 5 g of dopamine in water, pass in helium gas, add 2 times the amount of epichlorohydrin under the protection of helium gas, adjust the pH to 5-12, and react overnight to prepare a grafted activator.
[0047] 4. Disperse the product prepared in step 3 into the chitosan solution prepared in step 2, adjust pH to 4-10, stir overnight, and let stand for 24 hours.
[0048] 5. Under vigorous stirring, add genipin dropwise to the product obtained in the upper step to control the amount of genipin and control the degree of crosslinking to 0.1-10%.
[0049] 6. The product obtained in the previous step is freeze-dried, and a hemostatic sponge ...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More 
PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.
