34 results about "Tissue glueing" patented technology

The invention discloses a biomedical material and a product thereof. The biomedical material has main characteristic that a compound having a catechol group structure is grafted on chitosan to form a chitosan biomedical material having the catechol group structure; or the grafted chitosan is cross-linked to prepare a novel macromolecular biomedical material. The catechol has cell adhesion, so that tissue adhesiveness of the chitosan can be changed, and blood cells can be adsorbed on the material surface to achieve better bleeding-steeping effect. By virtue of the mediation, performance of the chitosan is improved, and tissue affinity is improved. The material is prepared into a novel bleeding-stopping sponge by freeze-drying, and prepared into novel dressing by spinning or prepared into powder dressing by reverse flocculating.

Hyaluronic acid and polyalkylene glycol (PAG) based materials have been found to exhibit a synergistic interaction, in which the viscosity of the mixture is more than twice as high as the viscosity expected from the viscosity of the individual components. The mixture otherwise has similar properties to those of its constituents, and in particular will crosslink to form covalently crosslinked gels if the PEG carries crosslinkable groups. The viscous formulation adheres well to tissue, and has applications as a tissue sealant and in tissue coating, prevention of adhesions, cell immobilization, regeneration of cartilage, bone and other tissue, as well as in controlled delivery of hyaluronic acid to sites in the body. Related materials exhibit similar effects.

The invention provides a method for preparing a tensionless net cloth for repairing hernia. The method comprises the following steps of: selecting medicinal polypropylene granules, assembling the polypropylene granules into a finished product by cutting and cleaning after three times of cooling, drafting, drawing and weaving processes, and sterilizing the finished product by using an ethylene oxide sterilizer for later use. The imported good-quality medicinal polypropylene granules are adopted in the method; monofilaments are woven into a mesh patch; and the patch has good biological tissue compatibility, can be quickly stuck and fixed with tissues, has no rejection reaction, has certain capability against infection, is an ideal hernia repair material, and has the same properties and functions as the imported product. The method creates a condition for clinical popularization and use, and has broad market prospect.

The invention belongs to the technical field of biomedical materials, and particularly relates to a solid composition for preparing a medical adhesive and the medical adhesive prepared from the solidcomposition. Vegetable polysaccharide is selected, is modified with aldehyde groups through an oxidation reaction, and is further cross-linked with an amino-containing polymer material in the presenceof water or a buffer solution to prepare the medical adhesive. The used materials are widely applied to the fields of medical treatment, foods and the like, have good biocompatibility, can be degraded and metabolized in vivo, and are low in price and wide in source; and the formed hydrogel type medical adhesive of a three-dimensional network structure has good application potential in the aspectsof tissue adhesion, filling, sealing, hemostasis and the like.

A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement. In addition, since the adhesive composition has excellent bio-absorbability, it is useful as fusion materials for artificial joint prosthesis, fusion materials for spine fracture, fusion materials for extremity fracture, filling materials for bone tumors in the region of orthopedics, filling materials and restorative materials at dental caries-defective sites, luting materials for prosthetic restorative materials such as inlay and crown, pulp-capping and lining materials, implant surface treatment materials, periodontal disease therapeutic materials, hyperesthesia preventive materials, dental pulp capping materials, substrates for DDS, substrates for systems engineering, and tissue bonding materials in the dental region.

The invention provides a visible light curing biological tissue binding material based on natural macromolecules as well as a preparation method and application of the visible light curing biological tissue binding material. The visible light curing biological tissue adhesive material comprises: a methylacryloylated natural polymer with amino on a main chain, wherein the grafting rate of methacrylic anhydride is 20-80%; oxidizing the polysaccharide; and the photoinitiator is used for initiating photocrosslinking of the methylacryloylated natural polymer. The biological tissue bonding material has good biocompatibility, cells can be adhered and proliferated on the surface or inside of the material, tissue bonding can be achieved under the controllable illumination condition according to needs, and the biological tissue bonding material is of a double-crosslinking network structure after being cured, has good mechanical strength, bonding strength and enzymolysis resistance, has high light transmittance, and can be used as a biological tissue bonding material. The adhesive has controllable curing and bonding processes, is convenient for adjustment and tissue involution before bonding, is simple and convenient to prepare and use, and has a good application prospect.

The invention discloses a single-sided adhesion tissue adhesion patch and a preparation method thereof. The single-sided adhesion tissue adhesion patch comprises a tissue adhesion layer and a dissipation layer, wherein the tissue adhesion layer is added to any surface of the dissipation layer; the tissue adhesion layer is provided with a tissue adhesion surface and a polymer matrix providing tissue adhesion; the dissipation layer comprises a polymer with biocompatibility and a toughening agent. The single-sided adhesion tissue adhesion patch is high in adhesion performance, and can be quickly adhered to achieve the effects of closing a wound and stopping bleeding after being adhered with tissue; the adhesion patch is only adhered on one side, the content of an active adhesive component is low, the content of an amino acid component is high, and the biocompatibility is good; the back surface of the patch is not adhered, and meanwhile, the patch is not adhered to tissue cells and proteins, so that the postoperative adhesion problem is prevented.

The invention relates to a preparation method of a drug-loaded antibacterial nano mesoporous silicon dioxide biological tissue adhesive and an application thereof in tissue adhesion. The preparation method of the drug-loaded mesoporous silicon dioxide comprises the following steps of preparing an oil-in-water emulsion from n-octane, cetyltrimethylammonium bromide and water, polymerizing a styrenemonomer and an ethyl orthosilicate monomer in an oil-phase liquid drop, and carrying out demulsifying, centrifuging, and high-temperature calcining to remove styrene, thereby obtaining mesoporous silicon dioxide nanoparticles; and adding the prepared silicon dioxide into a lysozyme solution to load lysozyme, and performing centrifuging and drying to obtain the anti-infection silicon dioxide biological tissue adhesive. The invention aims to overcome the defects of secondary injury caused by surgical suture or limitation that some organ tissues are not suitable for suture, poor effect of a traditional organic biological adhesive and the like in wound treatment. The adhesive has the advantages of quick action, no secondary trauma and the like, and has a wide application prospect in the fieldof wound treatment.

The invention discloses a tissue adhesive as well as a preparation method and application thereof. According to the tissue adhesive, when the tissue adhesive adheres to the surface of pigskin for lessthan 8h, the adhesion strength is smaller than or equal to 55kPa, and when the surface adhesion time is more than or equal to 8h, the adhesion strength I greater than 55kPa. Due to the fact that thetissue adhesive contains amino, phenolic hydroxyl and a natural cross-linking agent, the tissue adhesive can form non-covalent and covalent bonds with groups such as the amino and the sulfydryl on thesurface of tissue, and the tissue adhesive has high adhesion strength through the synergistic effect of multiple action bonds. The preparation method of the tissue adhesive is simple in process and low in raw material cost, and the tissue adhesive is a natural source material. The tissue adhesive has good biocompatibility, is high in adhesive strength under physiological conditions, is simple, convenient and safe to use, and has a good application prospect in tissue adhesion repair.

The invention discloses a mussel-like coordination adhesive based on epsilon-polylysine and a preparation method of the mussel-like coordination adhesive. Key factors of a mussel adhesion environmentare introduced into the design of a biological adhesive; and the prepared adhesive has tissue adhesion performance and low cytotoxicity. The preparation method comprises the following steps of: firstly, uniformly mixing epsilon-polylysine with 3,4-dihydroxyphenylpropionic acid under an oxygen-free condition, then adding 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride and N-hydroxysuccinimide into the mixture, and performing mixing and reacting to obtain the main component catechol modified epsilon-polylysine of the adhesive; dissolving PL-Cat in distilled water, adding Fe<3+> intothe distilled water, and adding NaOH to adjust the pH to be weakly alkaline, so that the PL-Cat/Fe adhesive can be obtained. The adhesive has good adhesive strength and low cytotoxicity, and has a wide application prospect in tissue engineering.

The present invention relates to a medical tissue-binding material, especially a soft tissue-binding material capable of attaching to a soft biological tissue such as a bone reconstruction material or a transdermal terminal, and a method for preparation thereof. In particular, the present invention relates to a medical tissue-binding material which comprises a base material having calcium binding onto the surface, provided that the base material is not titanium or titanium alloy. Also, the present invention relates to a method for preparing a medical tissue-binding material which comprises soaking a base material into a calcium ion containing solution. Introduction of at least one group selected from the group consisting of hydroxyl, carboxyl, sulfonate, amino, silanol and phosphate to the surface of the base material is effective for said method.

Disclosed is a biodegradable tissue adhesion patch and a preparation method thereof. The tissue adhesion patch comprises a tissue adhesion layer comprising a multi-polymer matrix providing tissue adhesion and a toughening polymer dispersed in the multi-polymer matrix, and an anti-adhesion layer comprising a polymer with the film-forming properties. The tissue adhesion patch in the invention has strong adhesive force and excellent cracking resistance.

Disclosed are compositions comprising a first polymer, a second branched polymer, and a third polymer reactive to the second polymer, where either of the second and third polymers comprises a tissue binding group, and where the second polymer and the third polymer are at least partially cross-linked. A matrix comprising the composition of the invention and optionally an additional polymer layer is disclosed. Methods for making the compositions and their use for bioadhesive and/or repair of damaged tissue are also disclosed.

The present invention relates to the preparation of a photo-crosslinkable biodegradable tissue adhesive using a copolymer and provides a hyaluronic acid copolymer compound having excellent elongation, mechanical properties and tissue adhesion. The compound does not undergo phase separation fundamentally and can produce a tissue adhesive having desired adhesive properties and physical properties.