35 results about "Tissue glueing" patented technology

The invention discloses a biomedical material and a product thereof. The biomedical material has main characteristic that a compound having a catechol group structure is grafted on chitosan to form a chitosan biomedical material having the catechol group structure; or the grafted chitosan is cross-linked to prepare a novel macromolecular biomedical material. The catechol has cell adhesion, so that tissue adhesiveness of the chitosan can be changed, and blood cells can be adsorbed on the material surface to achieve better bleeding-steeping effect. By virtue of the mediation, performance of the chitosan is improved, and tissue affinity is improved. The material is prepared into a novel bleeding-stopping sponge by freeze-drying, and prepared into novel dressing by spinning or prepared into powder dressing by reverse flocculating.

Hyaluronic acid and polyalkylene glycol (PAG) based materials have been found to exhibit a synergistic interaction, in which the viscosity of the mixture is more than twice as high as the viscosity expected from the viscosity of the individual components. The mixture otherwise has similar properties to those of its constituents, and in particular will crosslink to form covalently crosslinked gels if the PEG carries crosslinkable groups. The viscous formulation adheres well to tissue, and has applications as a tissue sealant and in tissue coating, prevention of adhesions, cell immobilization, regeneration of cartilage, bone and other tissue, as well as in controlled delivery of hyaluronic acid to sites in the body. Related materials exhibit similar effects.

The invention provides a method for preparing a tensionless net cloth for repairing hernia. The method comprises the following steps of: selecting medicinal polypropylene granules, assembling the polypropylene granules into a finished product by cutting and cleaning after three times of cooling, drafting, drawing and weaving processes, and sterilizing the finished product by using an ethylene oxide sterilizer for later use. The imported good-quality medicinal polypropylene granules are adopted in the method; monofilaments are woven into a mesh patch; and the patch has good biological tissue compatibility, can be quickly stuck and fixed with tissues, has no rejection reaction, has certain capability against infection, is an ideal hernia repair material, and has the same properties and functions as the imported product. The method creates a condition for clinical popularization and use, and has broad market prospect.

The invention belongs to the technical field of biomedical materials, and particularly relates to a solid composition for preparing a medical adhesive and the medical adhesive prepared from the solidcomposition. Vegetable polysaccharide is selected, is modified with aldehyde groups through an oxidation reaction, and is further cross-linked with an amino-containing polymer material in the presenceof water or a buffer solution to prepare the medical adhesive. The used materials are widely applied to the fields of medical treatment, foods and the like, have good biocompatibility, can be degraded and metabolized in vivo, and are low in price and wide in source; and the formed hydrogel type medical adhesive of a three-dimensional network structure has good application potential in the aspectsof tissue adhesion, filling, sealing, hemostasis and the like.

A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement. In addition, since the adhesive composition has excellent bio-absorbability, it is useful as fusion materials for artificial joint prosthesis, fusion materials for spine fracture, fusion materials for extremity fracture, filling materials for bone tumors in the region of orthopedics, filling materials and restorative materials at dental caries-defective sites, luting materials for prosthetic restorative materials such as inlay and crown, pulp-capping and lining materials, implant surface treatment materials, periodontal disease therapeutic materials, hyperesthesia preventive materials, dental pulp capping materials, substrates for DDS, substrates for systems engineering, and tissue bonding materials in the dental region.

Hyaluronic acid and polyalkylene glycol (PAG) based materials have been found to exhibit a synergistic interaction, in which the viscosity of the mixture is more than twice as high as the viscosity expected from the viscosity of the individual components. The mixture otherwise has similar properties to those of its constituents, and in particular will crosslink to form covalently crosslinked gels if the PEG carries crosslinkable groups. The viscous formulation adheres well to tissue, and has applications as a tissue sealant and in tissue coating, prevention of adhesions, cell immobilization, regeneration of cartilage, bone and other tissue, as well as in controlled delivery of hyaluronic acid to sites in the body. Related materials exhibit similar effects.

The invention provides a visible light curing biological tissue binding material based on natural macromolecules as well as a preparation method and application of the visible light curing biological tissue binding material. The visible light curing biological tissue adhesive material comprises: a methylacryloylated natural polymer with amino on a main chain, wherein the grafting rate of methacrylic anhydride is 20-80%; oxidizing the polysaccharide; and the photoinitiator is used for initiating photocrosslinking of the methylacryloylated natural polymer. The biological tissue bonding material has good biocompatibility, cells can be adhered and proliferated on the surface or inside of the material, tissue bonding can be achieved under the controllable illumination condition according to needs, and the biological tissue bonding material is of a double-crosslinking network structure after being cured, has good mechanical strength, bonding strength and enzymolysis resistance, has high light transmittance, and can be used as a biological tissue bonding material. The adhesive has controllable curing and bonding processes, is convenient for adjustment and tissue involution before bonding, is simple and convenient to prepare and use, and has a good application prospect.

The invention relates to a manufacture method of a lumen tissue construct. The manufacture method includes the steps that firstly, an elastic film is installed on a support in a sleeving manner; thirdly, a biological construct is printed on the elastic film; fifthly, a construct bonding layer is formed on the biological construct; and seventhly, a lumen tissue is bonded on the construct bonding layer. According to the manufacture method of the lumen tissue construct, the printed biological construct is assembled on the inner surface of the lumen tissue to form the lumen tissue construct, and therefore the problems, such as thrombus recurrence and lumen restenosis, caused after the lumen tissue construct is implanted for a long time are avoided, and the biological reliability of the lumen tissue construct is improved.

The invention discloses a single-sided adhesion tissue adhesion patch and a preparation method thereof. The single-sided adhesion tissue adhesion patch comprises a tissue adhesion layer and a dissipation layer, wherein the tissue adhesion layer is added to any surface of the dissipation layer; the tissue adhesion layer is provided with a tissue adhesion surface and a polymer matrix providing tissue adhesion; the dissipation layer comprises a polymer with biocompatibility and a toughening agent. The single-sided adhesion tissue adhesion patch is high in adhesion performance, and can be quickly adhered to achieve the effects of closing a wound and stopping bleeding after being adhered with tissue; the adhesion patch is only adhered on one side, the content of an active adhesive component is low, the content of an amino acid component is high, and the biocompatibility is good; the back surface of the patch is not adhered, and meanwhile, the patch is not adhered to tissue cells and proteins, so that the postoperative adhesion problem is prevented.

The invention provides a preparation method of a two-component medical adhesive, and belongs to the field of biomedical materials. The two-component instant adhesive is prepared by mixing a hyperbranched polymer which is in a liquid state at room temperature and has a thiol group as a terminal group and polyethylene glycol terminated by hexamethylene diisocyanate. The curing time of the adhesive is relatively short (1.5-3 min), so that the adhesive has a certain operation window, and the adhesive and the polyethylene glycol can be mixed and can be quickly cured when the adhesive is applied totissues. The medical adhesive can have a shear modulus close to that of various biological soft tissues by controlling the proportion of the two components, so that the interfacial stress concentration is relieved and the comfort of a patient is enhanced. The adhesive has very high tissue adhesiveness due to a large number of isocyanate groups and a solvent-free hyperbranched polymer network structure, and the adhesive property of the adhesive can be comparable with that of cyanoacrylate glue. The medical adhesive also has low swelling property and low toxicity, and has a great practical medical value.

The invention discloses a dual-component in-situ injection type polyasparagine bionic tissue adhesive and a preparing method thereof. The tissue adhesive is composed of a first polyasparagine component solution and a second polyasparagine component solution with different reactive functional groups. A first component is polyasparagine with a vinyl functional group, a catechol functional group anda hydroxyl functional group, a second component is polyasparagine with a sulfydryl functional group, a catechol functional group and a hydroxyl functional group, a solvent of the first component is ahydrogen peroxide solution, and a solvent of the second component is a horse radish peroxidase solution. The catechol functional groups in the first component and the second component have the marinemussel imitation adhesion characteristic and can have noncovalent interaction with a tissue surface, the adhesive has tissue adhesiveness, and tissue repairing is realized. The tissue adhesive has excellent tissue adhesive strength and use convenience and has important significance in replacing surgical sutures and healing wounds.

The invention relates to a preparation method of a drug-loaded antibacterial nano mesoporous silicon dioxide biological tissue adhesive and an application thereof in tissue adhesion. The preparation method of the drug-loaded mesoporous silicon dioxide comprises the following steps of preparing an oil-in-water emulsion from n-octane, cetyltrimethylammonium bromide and water, polymerizing a styrenemonomer and an ethyl orthosilicate monomer in an oil-phase liquid drop, and carrying out demulsifying, centrifuging, and high-temperature calcining to remove styrene, thereby obtaining mesoporous silicon dioxide nanoparticles; and adding the prepared silicon dioxide into a lysozyme solution to load lysozyme, and performing centrifuging and drying to obtain the anti-infection silicon dioxide biological tissue adhesive. The invention aims to overcome the defects of secondary injury caused by surgical suture or limitation that some organ tissues are not suitable for suture, poor effect of a traditional organic biological adhesive and the like in wound treatment. The adhesive has the advantages of quick action, no secondary trauma and the like, and has a wide application prospect in the fieldof wound treatment.

The invention discloses a tissue adhesive as well as a preparation method and application thereof. According to the tissue adhesive, when the tissue adhesive adheres to the surface of pigskin for lessthan 8h, the adhesion strength is smaller than or equal to 55kPa, and when the surface adhesion time is more than or equal to 8h, the adhesion strength I greater than 55kPa. Due to the fact that thetissue adhesive contains amino, phenolic hydroxyl and a natural cross-linking agent, the tissue adhesive can form non-covalent and covalent bonds with groups such as the amino and the sulfydryl on thesurface of tissue, and the tissue adhesive has high adhesion strength through the synergistic effect of multiple action bonds. The preparation method of the tissue adhesive is simple in process and low in raw material cost, and the tissue adhesive is a natural source material. The tissue adhesive has good biocompatibility, is high in adhesive strength under physiological conditions, is simple, convenient and safe to use, and has a good application prospect in tissue adhesion repair.

The invention discloses a mussel-like coordination adhesive based on epsilon-polylysine and a preparation method of the mussel-like coordination adhesive. Key factors of a mussel adhesion environmentare introduced into the design of a biological adhesive; and the prepared adhesive has tissue adhesion performance and low cytotoxicity. The preparation method comprises the following steps of: firstly, uniformly mixing epsilon-polylysine with 3,4-dihydroxyphenylpropionic acid under an oxygen-free condition, then adding 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride and N-hydroxysuccinimide into the mixture, and performing mixing and reacting to obtain the main component catechol modified epsilon-polylysine of the adhesive; dissolving PL-Cat in distilled water, adding Fe<3+> intothe distilled water, and adding NaOH to adjust the pH to be weakly alkaline, so that the PL-Cat / Fe adhesive can be obtained. The adhesive has good adhesive strength and low cytotoxicity, and has a wide application prospect in tissue engineering.

The present invention relates to a medical tissue-binding material, especially a soft tissue-binding material capable of attaching to a soft biological tissue such as a bone reconstruction material or a transdermal terminal, and a method for preparation thereof. In particular, the present invention relates to a medical tissue-binding material which comprises a base material having calcium binding onto the surface, provided that the base material is not titanium or titanium alloy. Also, the present invention relates to a method for preparing a medical tissue-binding material which comprises soaking a base material into a calcium ion containing solution. Introduction of at least one group selected from the group consisting of hydroxyl, carboxyl, sulfonate, amino, silanol and phosphate to the surface of the base material is effective for said method.

Disclosed is a biodegradable tissue adhesion patch and a preparation method thereof. The tissue adhesion patch comprises a tissue adhesion layer comprising a multi-polymer matrix providing tissue adhesion and a toughening polymer dispersed in the multi-polymer matrix, and an anti-adhesion layer comprising a polymer with the film-forming properties. The tissue adhesion patch in the invention has strong adhesive force and excellent cracking resistance.

The invention discloses a polysaccharide-based tissue bonding medical adhesive and application thereof. The polysaccharide-based tissue bonding medical adhesive is composed of a polysaccharide derivative and a compound with at least two reaction functional groups, wherein the polysaccharide derivative and the compound with at least two reaction functional groups generate a bonding effect through one or more of a physical effect and a chemical reaction; and the polysaccharide derivative is polysaccharide after functional group substitution. The polysaccharide-based tissue bonding medical adhesive can bear relatively large tension, has relatively short tissue bonding time and relatively high tissue stripping force compared with a cyanoacrylic acid medical adhesive, can realize rapid bonding and sealing of wounds, has strong adhesion with tissues after being applied, is not easy to strip, can be suitable for stretched wounds, and can realize effective closing.

The invention relates to a method for manufacturing a luminal tissue construct. The manufacturing method includes: step 1: covering the elastic film on the support; step 3: printing the biological construct on the elastic film; step 5: forming a construct adhesive layer on the biological construct; step 7: placing the luminal tissue Bonded to the construct adhesive layer. According to the manufacturing method of the luminal tissue construct of the present invention, the printed biological construct is assembled on the inner surface of the luminal tissue to form a luminal tissue construct, thereby avoiding the occurrence of thrombus after a long-term implantation of the luminal tissue construct. The emergence of issues such as recurrence and luminal restenosis improves the bioreliability of luminal tissue constructs.

The invention discloses a polysaccharide-based tissue bonding medical adhesive and application thereof. The polysaccharide-based tissue bonding medical adhesive is prepared from a polysaccharide derivative and a compound with at least two reaction functional groups, wherein the polysaccharide derivative and the compound with at least two reaction functional groups generate a bonding effect through one or more of physical action or chemical reaction; and the polysaccharide derivative is polysaccharide substituted by functional groups. The polysaccharide-based tissue bonding medical adhesive can bear larger tension; compared with a cyanoacrylate medical adhesive, the polysaccharide-based tissue bonding medical adhesive has the advantages of shorter tissue bonding time and higher tissue stripping force, and can realize quick bonding and sealing of wounds; and meanwhile, after application, the polysaccharide-based tissue bonding medical adhesive has strong adhesive force with tissues, is not easy to strip, can be suitable for stretched wounds, and can realize effective closing.

The invention relates to the preparation of a drug-loaded antibacterial nanometer mesoporous silicon dioxide biological tissue adhesive and its application in tissue adhesion. The preparation of the drug-loaded mesoporous silica includes the following steps: preparing an oil-in-water emulsion with n-octane, cetyltrimethylammonium bromide and water; The monomer is polymerized in the oil phase droplets, and the styrene is removed by demulsification, centrifugation and high-temperature calcination to obtain mesoporous silica nanoparticles; the prepared silica is added to the lysozyme solution to load the lysozyme, and the centrifugal drying Finally, the anti-infection silica biotissue adhesive is prepared. The invention aims to solve the disadvantages of secondary injury caused by surgical suture or limitations that certain organs and tissues are not suitable for suturing, poor effect of traditional organic bioadhesives and the like in wound treatment. It has the advantages of rapid action and no secondary trauma, and has broad application prospects in the field of wound treatment.

The invention discloses an injectable bioadhesive, its preparation method and application, and belongs to the technical field of polymer materials and biomaterials. The present invention selects carbohydrate macromolecules with good biocompatibility—dextran and chitosan oligosaccharides as the matrix, mixes them with dopamine and an oxidative cross-linking agent and disperses them in an aqueous solution, and undergoes rapid gelation, that is, a multi-cross-linked biological adhesive. The bioadhesive material obtained in the present invention not only has injectability, is convenient for practical application operation, can be applied to skin tissue, and can inject the required amount according to the size of the required bonding, etc., and it has higher mechanical strength, no Cytotoxicity and excellent tissue adhesion performance, can be applied to the adhesion of various materials such as animal skin, internal tissues and organs, glass, metals and their oxides, sealants, plastics, etc. in clinical surgery. It has broad application prospects in fields such as fusion and repair, hemostasis, packaging, and sealing.

Disclosed are compositions comprising a first polymer, a second branched polymer, and a third polymer reactive to the second polymer, where either of the second and third polymers comprises a tissue binding group, and where the second polymer and the third polymer are at least partially cross-linked. A matrix comprising the composition of the invention and optionally an additional polymer layer is disclosed. Methods for making the compositions and their use for bioadhesive and / or repair of damaged tissue are also disclosed.

A degradable, anti-adhesion double-layer dura mater patch and a preparation method thereof, the double-layer dura mater patch includes a dense layer and a porous layer; the dense layer faces the brain tissue side when the patch is used, It is used to prevent cerebrospinal fluid leakage, prevent brain tissue adhesion, and can be sutured; the porous layer faces the side of the skull when the patch is used, and is used to support the growth, migration, proliferation and differentiation of autologous dura mater cells, and promote autologous dura mater cells. The meninges are regenerated, and after hydrogelation, a tissue adhesive effect is produced to improve the sealing density. The dura mater patch has good flexibility, good mechanical properties and tissue compatibility, can significantly promote the regeneration of damaged meningeal tissue, has anti-adhesion and biodegradable properties, is easy to store, disinfect and prepare before surgery, and fully utilizes biological polysaccharides. The advantages of the material in tissue repair are extremely valuable.

The invention discloses a gel dressing prepared by spraying dry powder, which is prepared from a hydrophilic polymer into a gel, which is lyophilized, pulverized, and dried into a powder, which reaches the surface of the tissue by spraying, and absorbs water through ion complexation, hydrogen bonding or electrostatic force In-situ powder-to-powder cross-linking and tissue bonding are achieved. The dressing of the present invention is a dry powder before application, which is easy to store, does not contain initiators and monomers, and has high biocompatibility. The dry powder can absorb moisture on the surface of wet tissues, eliminate the adhesion barrier, and achieve rapid wet tissue adhesion. The adhesive strength of the tissue is high, which can reach 10-50kpa; the essence of the dry powder is modular, and functional materials can be added according to the needs, and the dry powder can be applied to the wound surface by using a spraying device; the hydrogel dressing is activated by water to form a dense water The gel layer can achieve strong tissue adhesion. Under the trigger of water, the swollen particles self-assemble into a gel mass on the surface of the wound in situ, and realize the tight adhesion to large-area and irregular wound biological tissues.

The invention discloses a polysaccharide-based tissue bonding medical adhesive and application thereof. The polysaccharide-based tissue bonding medical adhesive is composed of a polysaccharide derivative and a compound with at least two reaction functional groups, and the polysaccharide derivative and the compound with at least two reaction functional groups generate a bonding effect through one or more of a physical effect or a chemical reaction; and the polysaccharide derivative is polysaccharide substituted by a functional group. The polysaccharide-based tissue bonding medical adhesive can bear large tension, has fast tissue bonding time and high tissue stripping force compared with cyanoacrylic acid medical adhesive, can realize rapid bonding and sealing of wounds, has strong adhesion with tissues after being applied, is not easy to strip, can be suitable for stretched wounds, and can achieve effective closure.

The invention discloses a polysaccharide-based tissue bonding medical adhesive and application thereof. The polysaccharide-based tissue bonding medical adhesive is composed of a polysaccharide derivative and a compound with at least two reaction functional groups, wherein the polysaccharide derivative and the compound with at least two reaction functional groups generate a bonding effect through one or more of a physical effect and a chemical reaction; and the polysaccharide derivative is polysaccharide after functional group substitution. The polysaccharide-based tissue bonding medical adhesive can bear relatively large tension, has relatively short tissue bonding time and relatively high tissue stripping force compared with a cyanoacrylic acid medical adhesive, can realize rapid bonding and sealing of wounds, has strong adhesion with tissues after being applied, is not easy to strip, can be suitable for stretched wounds, and can realize effective closing.

The present invention relates to the preparation of a photo-crosslinkable biodegradable tissue adhesive using a copolymer and provides a hyaluronic acid copolymer compound having excellent elongation, mechanical properties and tissue adhesion. The compound does not undergo phase separation fundamentally and can produce a tissue adhesive having desired adhesive properties and physical properties.

The present application discloses a tissue adhesive and its preparation method and application. A tissue adhesive, which is on the surface of pigskin, when the surface adhesion time is less than 8h, the adhesion strength is ≤55kPa; when the surface adhesion time is ≥8h, the adhesion strength is >55kPa. Because the tissue adhesive contains amino groups, phenolic hydroxyl groups and natural cross-linking agents, it can form non-covalent and covalent bonds with groups such as amino groups and sulfhydryl groups on the surface of the tissue. Strong adhesion strength. The preparation method of the tissue adhesive has the advantages of simple process, low cost of raw materials, and all materials of natural origin. The tissue adhesive has good biocompatibility, high adhesive strength under physiological conditions, is easy and safe to use, and has a good application prospect in tissue adhesive repair.