18 results about "Tissue glueing" patented technology

The invention discloses a medical pressure-sensitive adhesive patch based on citric acid, a preparation method and application, the medical pressure-sensitive adhesive patch is composed of an adhesion layer and an anti-adhesion layer, and the thickness ratio of the adhesion layer to the anti-adhesion layer is 1: 1-100: 1; the adhesion layer is obtained by polymerizing a citric acid unit and a polyhydroxy compound unit; the hydrophobic high-molecular polymer is selected from at least one of a polylactic acid-glycolic acid copolymer, polylactic acid, polyurethane and polyether urethane. According to the preparation method, three carboxyl groups in the citric acid not only can be used for esterification reaction with polyhydric alcohols to form a network, but also can provide excellent adhesive force for contact between the adhesive patch and the tissue surface through electrostatic interaction or hydrogen-bond interaction. The anti-sticking layer prepared from the hydrophobic high-molecular polymer can effectively resist invasion of external moisture and bacteria, so that the service time of the adhesive patch is prolonged; meanwhile, the anti-sticking layer can also play a supporting role, so that the mechanical strength of the adhesive tape is improved.

The present invention relates to a tissue adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue reactive polymer, and a tissue adhesive device for sealing the dura mater comprising the tissue adhesive polymer blend.

Provided is a porous sheet having high biocompatibility and adhesive strength, and further having pliability and / or flexibility.　The porous sheet includes: a second gelatin having a hydrocarbon group introduced into a first gelatin; and an unreacted crosslinking agent dispersed in the second gelatin. The second gelatin includes a structure represented by formula (1).

The invention provides a tissue adhesive material as well as a preparation method and application thereof. The tissue bonding material is prepared from the following raw materials: a polymer monomer, wherein the polymer monomer comprises an acrylic monomer and an acrylamide monomer; the modified chitosan compound is obtained by modifying a chitosan compound through a polyphenol compound, and the polyphenol compound has two or more phenolic hydroxyl groups; and an initiator, wherein the initiator comprises a photoinitiator and a radical initiator. When the tissue bonding material is in contact with a wet or wet tissue surface, interface liquid existing between the bonding material and the wet tissue surface can be quickly absorbed and removed, and carboxyl, amido and catechol groups of the tissue bonding material can form a large number of molecular bonds with molecules on the wet tissue surface, so that instant bonding on the wet tissue surface is formed; and high adhesiveness can be maintained for a long time.

The present application relates to the field of medical devices, in particular to a preparation method of a self-fixing patch and application thereof. The present application provides a self-fixing patch, the self-fixing biological patch comprising a patch material layer, the patch material layer being loaded or coated with a glue film layer. The micropores on the surface of the glue film layer of the self-fixing patch of the present application are spaced apart from each other by tens of microns, and a uniform micropore array can be regularly formed on the surface of the glue film layer. Due to the existence of the micropore array, the surface roughness and specific surface area of the tissue-adhesive glue film layer are improved, the tissue-adhesive glue film layer is more easily combined with the tissue, and has a positive influence on the adhesion, migration and differentiation of cells. The various micropore structures can adapt to complex tissue surfaces. The tissue-adhesive glue film layer maintains stability by dissipating the matrix through the micropore structure, and the micropore structure is beneficial to strengthening the tissue adhesion performance.

An adhesive tissue covering may include a base membrane and a biodegradable and biocompatible adhesive configured to bond to tissue. The adhesive may be located along one or more edges of the base membrane. In some aspects, an adhesive tissue strip may include a base membrane formed of at least one of a tissue-based material or a resorbable polymer, and a biodegradable and biocompatible adhesive configured to bond to tissue. The adhesive may be located on one side of the base membrane of the adhesive tissue strip.

The invention discloses a stem cell microcapsule-entrapped tissue adhesive, a preparation method and application, the tissue adhesive is composed of stem cell microcapsule-entrapped hydrogel and a biological adhesive, and live stem cells are entrapped in the tissue adhesive; the stem cells are selected from at least one of umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells, adipose-derived stem cells, embryonic stem cells and induced pluripotent stem cells; the biological adhesive is formed by compounding a hydrophilic polymer and a block polymer, wherein the mass ratio of the hydrophilic polymer to the block polymer is (1: 5)-(5: 1); the transmittance of the tissue adhesive is 60-100%, the tissue adhesive strength is 20-200 kPa, and the volume swelling ratio is smaller than or equal to 50%. According to the scheme, the stem cell entrapped microcapsule and the biological adhesive are mixed to prepare the tissue adhesive, and the adhesive can be used as bio-ink to be assembled into a bionic scaffold through 3D printing or directly injected to an injured part, so that the tissue adhesive has a wide application prospect.

The application discloses a photocured biological tissue adhesive patch and a preparation method and application thereof, and relates to the technical field of biomedical materials. The photocured biological tissue adhesive patch comprises a composite polymer soluble microneedle, wherein the photocured biological tissue adhesive patch is prepared from a prepolymer solution comprising the following components: (1) methacrylated gelatin (GelMA); (2) oxidized dextran (ODex); (3) polyvinyl alcohol (PVA); and (4) a photoinitiator, wherein the photoinitiator comprises LAP; and the weight ratio of the methacrylated gelatin, the oxidized dextran, the polyvinyl alcohol and the photoinitiator is (5-10):(3-6):(3-8):(0.05-0.3). The photocured biological tissue adhesive patch has excellent tissue integration promotion effect, is particularly suitable for a conjunctival transplantation and other surgeries requiring high-quality tissue integration, has wide clinical application adaptability and good industrialization prospect.

The present application provides a kind of degradable bio-based tissue adhesive material, which is formed by the one-step polymerization reaction of the light initiation of the complex of degradable amino acid end-capped bio-based supramolecular aqueous polyurethane, acrylic acid or its derivative and plasticizer, to form a transparent tissue adhesive material with double network structure.The adhesive material has the characteristics of instantaneous tissue adhesion, high bonding strength, high mechanical strength and plastic deformation capacity, and is suitable for biomedical fields such as rapid hemostasis of bleeding wounds, rapid closure of damaged wounds and repair of damaged soft tissues.The material also has biodegradability and excellent biocompatibility.In addition, compared with general tissue adhesive materials, the preparation process of the material is simple, the repetition rate is high, and the application range is wider.

The invention provides a tissue bonding patch as well as a preparation method and application thereof. The tissue bonding patch is prepared from the following raw materials: monomers, wherein the monomers comprise acrylic acid monomers and / or acrylamide monomers; a modified polymer compound that has a methacryloyl group; and a photoinitiator. The photoinitiator in the tissue bonding patch can initiate crosslinking of the monomer and the modified high-molecular compound to form a multi-crosslinked network structure, so that the mechanical property of the patch is improved, the swelling degree of the patch after liquid absorption is reduced, and the patch has good and lasting tissue adhesiveness; moreover, the tissue bonding patch is in a dry film shape or a film shape, is convenient to store and use, and has good biocompatibility.

The application belongs to the technical field of biomedical tissue adhesive materials, and relates to a rapid asymmetric tissue sealing patch as well as a preparation method and application thereof. The rapid asymmetric tissue sealing patch is composed of a strong water-absorbing biological adhesion layer and a hydrophobic biological anti-adhesion layer which is spin-coated on the strong water-absorbing biological adhesion layer. The rapid asymmetric tissue sealing patch provided by the application can realize strong adhesion between a wet dynamic tissue and an engineering solid within 5 seconds, can seal the tissue, and can improve the prevention effect of anastomotic leakage. Meanwhile, the rapid asymmetric tissue sealing patch has excellent anti-adhesion performance, can achieve the effect of preventing tissue adhesion after operation, and can be used in the repair of gastrointestinal defects.

The invention relates to the technical field of medical care instruments, in particular to a novel healing-promoting and adhesion-preventing ostomy bag which comprises a bag body, an opening is formed in one side of the bag body, a diaphragm is fixedly connected to one side of the bag body and covers the opening, a hot-melt tissue bonding layer is coated on one side of the diaphragm, and the hot-melt tissue bonding layer is coated on the other side of the diaphragm. A fixing belt is arranged on the other side of the bag body, and a first fixing disc is fixedly connected to one side of the fixing belt; the hot-melt tissue bonding layer is solidified into compact gel at the body temperature, gapless sealing is formed in cooperation with extrusion of the air bag, extremely high barrier performance is achieved for loose stool and intestinal flatulence of patients in the digestive system department, and the leakage rate is reduced to 5% or below; the antibacterial peptide component added in the bonding layer can inhibit the breeding of intestinal bacteria and reduce the irritation of excrement to the skin, and by combining with the medical breathable composite bag body, the incidence rate of irritant dermatitis around the stoma is reduced by more than 60%, and the nursing workload of the digestive system department is greatly reduced.

This invention discloses a wet tissue surface adhesive material, its preparation method, and its application, relating to the field of biomedical materials technology. The wet tissue surface adhesive material comprises: (1) dopamine-modified methacryloyl hyaluronic acid (HAMA-DOPA); (2) Pluronic F127-diacrylate (F127DA); (3) aldehyde-modified polyether F127 (F127CHO); (4) oxidized methacryloyl hyaluronic acid (OHAMA); and (5) a photoinitiator for initiating a photopolymerization reaction of the methacryloyl groups and acrylate groups in the above components under visible light irradiation. The photoinitiator comprises at least one of: lithium phenyl (2,4,6-trimethylbenzoyl) phosphate or a photoinitiator composition, wherein the photoinitiator composition comprises: eosin Y at a concentration of 0.05 to 0.25 mmol / L; triethanolamine at a mass-volume ratio of 1.5% to 3%; and N-vinylcaprolactam at a mass-volume ratio of 1% to 2%. This invention enables rapid, strong, and safe tissue adhesion.

The invention provides hydrophilic polyurethane and a derivative thereof, an adhesive hydrogel prepared from the derivative and application of the adhesive hydrogel, the adhesive hydrogel is a high polymer material with excellent adhesion, mechanical property and biocompatibility, has strong wet tissue adhesion, high toughness and low swelling property, and can be used for preparing the hydrophilic polyurethane and the derivative of the hydrophilic polyurethane as well as the adhesive hydrogel prepared from the derivative of the hydrophilic polyurethane and the derivative of the hydrophilic polyurethane. Meanwhile, the adhesive has the advantages of high efficiency, safety, convenience, mildness and the like, is an ideal tissue adhesive material, and can be used for adhering and closing an esophageal anastomotic stoma.

This invention provides a Janus tissue adhesive patch, its preparation method, and its uses. The patch comprises: a substrate, an anti-adhesion layer, and an adhesive layer; the substrate is located between the anti-adhesion layer and the adhesive layer; the anti-adhesion layer contains a phosphorylcholine compound, which is derived from a compound represented by the following formula (1): (1) where R1 represents a hydrogen atom, a halogen atom, and C1~C1. 10 Alkyl groups, C2~C 10 alkenyl, C2~C 10 alkynyl group or C1~C 10 The alkoxy group; R2 and R3 may be the same or different, each independently representing C1~C2. 10 alkylene or C2~C 10 The alkenyl group; R4, R5, and R6 may be the same or different, each independently representing a hydrogen atom, a halogen atom, or C1~C2. 10 Alkyl groups, C2~C 10 alkenyl, C2~C 10 alkynyl group or C1~C 10 The alkoxy group; the adhesive layer is derived from the adhesive, which includes monomers, crosslinking agents and antimicrobial agents.

The invention provides a composite tissue bonding patch as well as a preparation method and application thereof. The composite tissue bonding patch comprises a base body and micro-nano fibers formed with the base body in a composite mode. Wherein the micro-nano fibers are continuously or discontinuously dispersed in the base body. The composite tissue bonding patch disclosed by the invention is low in swelling degree, good in mechanical property and lasting in adhesiveness. After the composite tissue bonding patch is in contact with a wet tissue surface, interface liquid existing between the bonding patch and the wet tissue surface can be rapidly absorbed and removed, and a large number of instant molecular bonds can be formed between carboxylic acid and / or amino groups in the composite tissue bonding patch and molecules on the wet tissue surface; and rapid adhesion to a wet surface is realized. Moreover, the swelling degree of the composite tissue bonding patch is low, so that the patch can be prevented from falling off due to deformation caused by excessive water absorption, and the long-time strong adhesiveness can be maintained.

The invention discloses an underwater tissue binding material as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The underwater tissue adhesive material comprises the following components: (1) dopamine modified methacrylated hyaluronic acid (HAMA-DOPA), and (2) a crosslinking agent, (2) preparing methacrylated hyaluronic acid (HAMA-PBA) modified by phenylboronic acid; (3) polyvinyl alcohol (PVA); (4) a photoinitiator, which is used for initiating a copolymerization reaction of methacryloyl groups in the HAMA-DOPA and the HAMA-PBA under the irradiation of visible light so as to form a covalent cross-linked network; the weight ratio of the dopamine modified methacrylated hyaluronic acid to the phenylboronic acid modified methacrylated hyaluronic acid to the polyvinyl alcohol to the photoinitiator is (2 to 5) to (1 to 3) to (1 to 3) to (0.1 to 0.25). The hydrogel has the advantages of excellent underwater stability, fast and controllable curing process, strong underwater bonding strength and good biocompatibility, and is especially suitable for repairing sensitive tissues such as retina and the like.

The invention discloses an anti-swelling self-fixing tissue adhesion sealant based on a micro-nano element, which comprises an adhesive, and the adhesive is prepared from the following components: a hydrophilic polymer of an end group modified initiating polymerization reaction group, the micro-nano element, an initiator and water. According to the anti-swelling self-fixing tissue bonding sealant based on the micro-nano element, the end group modified hydrophilic polymer of the polymerization initiating group and the micro-nano element are selected, and the end group modified hydrophilic polymer of the polymerization initiating group can have good affinity with tissues and have deeper penetration depth for the tissues; the micro-nano elements with hydrophobic fragments can reduce swelling, and meanwhile, the micro-nano elements are selected to provide more energy dissipation for the adhesive.