Esomeprazole sodium bicarbonate composition
A technology of esomeprazole and sodium bicarbonate, applied in drug combination, active ingredients of aluminum/calcium/magnesium, digestive system, etc.
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Embodiment 1
[0020] Esomeprazole Sodium Bicarbonate Capsules:
[0021] Esomeprazole Magnesium 44g
[0022] Sodium bicarbonate 1100g
[0023] Sodium carboxymethyl starch 90g
[0024] Sodium stearoyl fumarate 10g
[0025] Grind esomeprazole magnesium, sodium bicarbonate and sodium carboxymethyl starch and sieve, mix uniformly, dry granulate, pass through a 20-mesh sieve, add stearoyl sodium fumarate, mix, put into capsules, Instantly.
[0026]
Embodiment 2
[0028] Esomeprazole Sodium Bicarbonate Dry Suspension:
[0029] Esomeprazole Magnesium 22g
[0030] Sodium bicarbonate 1680g
[0031] Sorbitol 1200g
[0032] Hydroxypropyl Methyl Cellulose 200g
[0033] Sucrose 1200g
[0034] Appropriate amount of flavoring agent
[0035] Sieve esomeprazole, sodium bicarbonate, sorbitol, hydroxypropyl methylcellulose, sucrose, and flavoring agent separately, mix evenly, and pack separately to obtain the product.
[0036]
Embodiment 3
[0038] Esomeprazole Sodium Bicarbonate Chewable Tablets:
[0039] Esomeprazole Magnesium 22g
[0040] Sodium bicarbonate 1680g
[0041] Mannitol 385g
[0042] Sucrose 200g
[0044] Appropriate amount of flavoring agent
[0045] Grind esomeprazole magnesium, sodium bicarbonate, mannitol, sucrose, flavoring agent, magnesium stearate, and essence respectively, and sieve, and mix esomeprazole magnesium, sodium bicarbonate, mannitol, sucrose, Mix correctives and flavors evenly, dry granulate, pass through a 20-mesh sieve, add magnesium stearate, mix, and compress into tablets.
[0046]
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