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A technology of esomeprazole and sodium bicarbonate, applied in drug combination, active ingredients of aluminum/calcium/magnesium, digestive system, etc.
Inactive Publication Date: 2011-06-01
BEIJING HONGWAN PHARMA TECH
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Problems solved by technology
But so far there is no single dosage form of esomeprazole and sodium bicarbonate in China
Method used
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Embodiment 1
[0020] Esomeprazole Sodium Bicarbonate Capsules:
[0021] Esomeprazole Magnesium 44g
[0022] Sodium bicarbonate 1100g
[0023] Sodium carboxymethyl starch 90g
[0024] Sodium stearoyl fumarate 10g
[0025] Grind esomeprazole magnesium, sodium bicarbonate and sodium carboxymethyl starch and sieve, mix uniformly, dry granulate, pass through a 20-mesh sieve, add stearoyl sodium fumarate, mix, put into capsules, Instantly.
[0045] Grind esomeprazole magnesium, sodium bicarbonate, mannitol, sucrose, flavoring agent, magnesium stearate, and essence respectively, and sieve, and mix esomeprazole magnesium, sodium bicarbonate, mannitol, sucrose, Mix correctives and flavors evenly, dry granulate, pass through a 20-mesh sieve, add magnesium stearate, mix, and compress into tablets.
[0046]
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Abstract
The invention relates to an oral medicinal composition formulation for treating peptic ulcer. The composition comprises esomeprazole, antiacid sodium bicarbonate and a medicinally acceptable carrier, wherein the esomeprazole contains an acid-sensitive proton pump inhibitor; and the antiacid sodium bicarbonate can improve the stability of the proton pump inhibitor. The invention also relates to a preparation method of the medicinal composition. Two active ingredients are integrated into one fixed unit formulation, so that response is quick, a medicinal scheme is simplified in the process of treating the peptic ulcer, and the compliance of a patient is improved.
Description
technical field [0001] The invention relates to an oral pharmaceutical composition for treating peptic ulcer, in particular to a compound preparation composed of esomeprazole and sodium bicarbonate and a preparation method thereof. Background technique [0002] Peptic ulcer refers to gastric and duodenal ulcers. It is generally believed that mucosal injury factors (gastric acid, pepsin, Helicobacter pylori, etc.) and protective factors (gastric mucosal blood flow, mucus barrier, and prostaglandins) are in a state of balance. sexual ulcers. Peptic ulcer is associated with gastric Helicobacter pylori infection, weakened mucosal protection, and hyperacidity. With my country's social development, environmental changes, population structure and changes in people's lifestyles, the incidence of peptic ulcers has gradually increased. The current clinically used drugs for the treatment of peptic ulcer mainly include proton pump inhibitors, H 2 Receptor antagonists, M 1 Choline r...
Claims
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Application Information
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