Esomeprazole magnesium injection liquid

Abstract

The invention discloses an esomeprazole magnesium injection liquid capable of treating gastroesophageal reflux disease. At present, esomeprazole magnesium in the market is only tablets, and the patient needs to take the esomeprazole magnesium for 1 to 3 times per day; and because the dosage taken by the patient per day is large and the frequency is high, side effects generated by the medicine are large, too. In order to solve the problems, the invention aims to provides the esomeprazole magnesium injection liquid with convenient clinical use, high bioavailability and low price, which can make the medicine quickly reach effective treatment concentration in vivo through direct intravenous injection or intramuscular injection, reduce first-pass effect of the medicament in liver and improve the bioavailability of the medicament in vivo. The esomeprazole magnesium injection liquid provided by the invention mainly comprises the esomeprazole magnesium or pharmaceutically acceptable salts thereof and solvent for injection; and 1 ml of the injection liquid comprises 10 to 200 mg of the esomeprazole magnesium or the pharmaceutically acceptable salts thereof, and the pH of the injection liquid is between 3.0 and 8.0.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a tube esomeprazole magnesium esomeprazole magnesium injection capable of treating gastroesophageal reflux disease. Background technique [0002] Esomeprazole magnesium is the S-isomer of omeprazole, which reduces gastric acid secretion through a specific targeting mechanism and is a specific inhibitor of lipid pumps in parietal cells. For gastroesophageal reflux disease: treatment of erosive reflux esophagitis, long-term maintenance treatment to prevent recurrence of cured esophagitis patients, and also used in combination with appropriate antibacterial therapy to eradicate gastric ulcer, duodenal ulcers and prevent their recurrence. [0003] At present, the esomeprazole magnesium on the market only has tablets, and patients need to take it 1 to 3 times a day. Because the patient takes a larger dose and more times a day, the side effects of the drug are also relatively large. ...

AI Technical Summary

Problems solved by technology

[0003] At present, the esomeprazole magnesium on the market only has tablets, and patients need to take it 1 to 3 times a day. Because the patient takes a larger dose and more times a day, the side effects of the drug are also relatively large. Chinese patent 200810111831.0 discloses the dosage form of drop pills, which solves the problem of low bioavailability of tablets. This patent also explains the defects of drop pills, that is, if the formulation or preparation method of the carrier and the drug is unreasonable, in the long-term storage It is easy to produce some unstable phenomena, that is, aging phenomenon, which increases the drug-related substances under long-term room temperature storage conditions and reduces the bioavailability. Therefore, under certain conditions, the superiority of dripping pills is offset.