Amphiphilic acid-sensitive ternary molecular brush polymer constructed acid-sensitive nanocapsule

A ternary molecular brush and nanocapsule technology is applied in the field of self-assembled polymer materials to achieve the effect of simple operation
CN103289099AActive Publication Date: 2013-09-11GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
Publication Date
2013-09-11

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Abstract

The invention discloses an amphiphilic acid-sensitive ternary molecular brush polymer constructed acid-sensitive nanocapsule of which the general formula is disclosed in the specification, wherein A is a polymer main chain, B is a lipophilic high-polymer side chain, C is an acid-sensitive high-polymer side chain, D is a hydrophilic high-polymer side chain, and the side chains B, C and D are randomly grafted on the main chain A; and the amphiphilic acid-sensitive ternary molecular brush polymer is dispersed in an oil / water two-phase system to form the stable acid-sensitive nanocapsules. The invention solves the problem that the traditional intelligent nanocapsule can not easily and effectively regulate the substance release rate; the emulsion self-assembly process for preparing the nanocapsule is simple to operate, and can easily implement large-scale preparation; and the prepared hollow acid-sensitive nanocapsule has high coating capacity. A-g-(B-r-C-r-D).
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Description

technical field

[0001] The invention belongs to the field of self-assembled polymer materials, and in particular relates to an acid-sensitive nanocapsule constructed by an amphiphilic acid-sensitive ternary molecular brush polymer. Background technique

[0002] In recent decades, in order to improve the performance of drug delivery systems and reduce the side effects on the human body during drug delivery, micelles formed by amphiphilic polymers self-assembled in solutions have been used as drug carriers. On the one hand, these drug carriers can carry poorly water-soluble drugs and increase the delivery capacity of the drugs; on the other hand, they can provide protection for the drugs and perform slow release at an appropriate time.

[0003] Nanopolymer micelles have shown great potential application value in the delivery of drugs, such as anticancer drugs. However, a burst release of 10–30% of a physically entrapped drug is typically achieved within hours, followed by ver...

Claims

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