Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Nanometer material of mesoporous silica coated trimanganese tetroxide for modifying CuS nano particles, as well as preparation method and application thereof

A technology of mesoporous silica and trimanganese tetroxide, which is applied to wave energy or particle radiation treatment materials, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve severe photobleaching, low photothermal conversion rate, etc. question

Inactive Publication Date: 2014-09-10
SHANGHAI NORMAL UNIVERSITY
View PDF3 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional organic compounds, such as indocyanine green and polyaniline, suffer from low photothermal conversion and severe photobleaching

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nanometer material of mesoporous silica coated trimanganese tetroxide for modifying CuS nano particles, as well as preparation method and application thereof
  • Nanometer material of mesoporous silica coated trimanganese tetroxide for modifying CuS nano particles, as well as preparation method and application thereof
  • Nanometer material of mesoporous silica coated trimanganese tetroxide for modifying CuS nano particles, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Mn 3 o 4 mSiO 2 Synthesis of CuS:

[0034] 1) Add 8mL of oleylamine to a PTFE inner village with a capacity of 10mL, and take 1mL of Mn(NO 3 ) 2 (50%) aqueous solution was added dropwise to oleylamine, stirred while adding, and then the reactor was sealed and placed in an atmosphere of 200° C. for 5 hours. After cooling to room temperature, the upper liquid was poured out, and the obtained nanomaterials sank to the bottom of the reactor. Wash with ethanol 2 to 3 times. Soluble in organic solvent chloroform (CHCl 3 ) to save.

[0035] pass figure 1 with figure 2 It can be shown that the prepared nanoparticles are Mn 3 o 4 Nanoparticles, and oil-soluble nanoparticles have good dispersibility.

[0036] 2) The above nanoparticles are changed from oil-soluble to water-soluble: prepare 0.055M cetyltrimethylammonium bromide (CTAB), weigh 200mg of cetyltrimethylammonium bromide (CTAB), dissolve in 10mL H 2 O.

[0037] 3) Take the concentration as 20mg·...

Embodiment 2

[0053] Detection of singlet oxygen:

[0054] Weigh 16.5 mg of dimethyl anthracene (DMA), and prepare a solution with a concentration of 20 mM. Add the DMA solution to the Mn-containing 3 o 4 mSiO 2 CuS / PEG or Mn 3 o 4 mSiO 2 CuS / PEG / MB solution was formed at a final concentration of 20 μM. The mixed solution was used with a 632.8nm He-Ne laser (80mW·cm -2 , HT-150, Nanjing Laichuang Technology Co., Ltd.) to irradiate. The decrease in fluorescence intensity of DMA is a sign of singlet oxygen generation, its detection is excited at 360nm, and the wavelength scanning range of the emission spectrum is 380-550nm. All samples need to be shaken well before testing, and ensure that the laser is irradiated to all samples. Methylene blue (MB) is a water-soluble phenothiazine derivative. MB is a promising photosensitizer that can generate singlet oxygen under 632.8nm laser irradiation, so it can be used in photodynamic therapy. Encapsulation of MBs in nanoparticles is a feasib...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a nanometer material (Mn3O4@mSiO2@CuS) of mesoporous silica coated trimanganese tetroxide for modifying CuS nano particles, as well as a preparation method and an application thereof; the particle size of the nanometer material is about 70 nm; modified photosensitizer molecule methylene blue (MB) can generate singlet oxygen under excitation of 632.8 nm laser so as to kill cancer cells; and CuS can generate heat under irradiation of 980 nm laser to kill cancer cells more effectively. In cellular level experiments, the nanometer material disclosed by the invention has good biocompatibility; cancer cells can be effectively killed under the synergistic effect of optical thermal therapy and photodynamic therapy in the therapeutic process; and the nanometer material disclosed by the invention is expected to be further researched and applied as a multifunctional material in combination with diagnosis and therapy in the field of nanometer medicines.

Description

technical field [0001] The present invention relates to a kind of nanometer material (Mn 3 o 4 mSiO 2 CuS) and its preparation method and application belong to the field of organic-inorganic nanocomposite materials. Background technique [0002] Magnetic nanomaterials have broad application prospects in the fields of mechanics, electronics, optics, magnetism, chemistry and biology. The application of magnetic nanoparticles in targeted drug delivery, biomolecular separation and detection, and bioimaging is also a hot research topic in the field of biomedicine, and some have entered clinical trials. MRI can image various parts of the human body from multiple angles and planes. It has high resolution, can objectively and specifically display the anatomical tissues and adjacent relationships in the human body, and can well locate and characterize lesions. MRI is of great value in the diagnosis of diseases in various systems of the body, especially in the early diagnosis of t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K41/00A61K49/08
Inventor 吴惠霞汤才志郭琳琳杨仕平
Owner SHANGHAI NORMAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com