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Macromolecule based preparation method of pH-responsive metal-organic coordination polymer

A coordination polymer and metal-organic technology, applied in the field of preparation of nano-medicine technology, to achieve the effect of broad application prospects

Inactive Publication Date: 2011-01-19
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the preparation of drugs into metal-organic polymers with the help of biocompatible polymers is still a blank in the science classroom, and the pH sensitivity of "zero release" of drugs in near-neutral normal tissues and massive release in weakly acidic diseased tissues Drug delivery systems remain a scientific puzzle

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  • Macromolecule based preparation method of pH-responsive metal-organic coordination polymer
  • Macromolecule based preparation method of pH-responsive metal-organic coordination polymer
  • Macromolecule based preparation method of pH-responsive metal-organic coordination polymer

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Dissolve 0.20 mg of mitoxantrone in 1 ml of ethanol to form a drug solution, and then add 10 μl of 0.2mol / L copper nitrate ethanol solution and 100 μl of 20g / L polyethylene to the drug solution while stirring at room temperature. Alcohol 4000 ethanol solution; add 25μl 0.1mol / L sodium hydroxide solution, then drop 3ml ethyl acetate, stir for 30 minutes, centrifuge, wash, and vacuum dry at room temperature to obtain a blue-black solid powder material.

[0024] The pH responsiveness of the metal organic coordination polymer was evaluated as follows. The obtained blue-black solid powder was dispersed in 50 mM pH 7.4 phosphate buffer solution, stirred at room temperature, and the pH value of the solution was adjusted to pH 6.0 with dilute hydrochloric acid. pH5.0, pH4.0, regular sampling, centrifugation, the supernatant was diluted with 1N HCl and then quantitatively determined by UV. The results are as follows: only 4% was released in the pH 7.4 solution, 18% in the pH 6.0 so...

Embodiment 2

[0031] Dissolve 0.20mg of mitoxantrone in 1ml of ethanol to form a drug solution, and then add 18μl of 0.2mol / L ferric nitrate ethanol solution and 200μl of 20g / L polyethylene to the drug solution under stirring at room temperature. Alcohol 4000 ethanol solution; then 3ml ethyl acetate was added dropwise, stirred for 30 minutes, centrifuged, washed, and vacuum dried at room temperature to obtain a blue-black solid powder material.

[0032] The pH responsiveness of the metal organic coordination polymer was evaluated as follows. The obtained blue-black solid powder was dispersed in 50 mM pH 7.4 phosphate buffer, stirred at room temperature, and the pH of the solution was adjusted to pH 6.0 with dilute hydrochloric acid. pH5.0, pH4.0, regular sampling, centrifugation, the supernatant was diluted with 1N HCl and then quantitatively determined by UV. The results are as follows: only 11% is released in pH 7.4 solution, 17% is released in pH 6.0 solution, 23% is released in pH 5.0 solu...

Embodiment 3

[0035] Dissolve 10mg chito-oligosaccharide (3000) and 100mg F127 in 5ml deionized water to form a polymer solution, then add 1ml 2.0×10 to the above solution while stirring at room temperature -3 mol / L Alizarin Red ethanol solution; add 50μl 0.2mol / L cobalt nitrate ethanol solution, add 300μl 0.1mol / L sodium hydroxide solution to adjust the pH of the solution to 7, then add 10ml acetone dropwise, stir for 10 minutes and then add 100 μl, 1% sodium sulfate aqueous solution, stirred for another 30 minutes, centrifuged, washed, and freeze-dried to obtain a purple-red solid powder material.

[0036] The pH responsiveness of the metal organic coordination polymer was evaluated as follows. The obtained purple-red solid powder was dispersed in 50 mM pH 7.4 phosphate buffer, stirred at room temperature, and the pH of the solution was adjusted to pH 6.0 with dilute hydrochloric acid. pH5.0, pH4.0, regular sampling, centrifugation, the supernatant was diluted with 1N HCl and then quantitativ...

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Abstract

The invention relates to a macromolecule based preparation method of pH-responsive metal-organic coordination polymer in the technical field of nanomedicine, comprising the steps of: dissolving the biocompatible macromolecule in the deionized water, orderly adding the medicinal solution and the metal nitrate solution while stirring and adjusting the pH to be neutral with the alkali, then orderly adding the poor solvent and the metal sulfate solution, and centrifugally washing and drying to obtain the pH-responsive metal-organic coordination polymer. In the invention, the medicine is prepared into the nanoscale metal-organic coordination polymer by means of the biocompatible macromolecule and the metal ion, and the invention can perform controllable release to the medicine according to the small change of the pH.

Description

Technical field [0001] The invention relates to a preparation method in the technical field of nanomedicine, in particular to a preparation method of a polymer-based pH response metal organic coordination polymer. Background technique [0002] The pH-responsive drug release system is a type of smart drug release system, which can release drugs in a controlled manner according to the pH of the environment. The extracellular environment of human tumors (pH 5.7-7.8) is more acidic than normal blood or tissues (pH about 7.4), and the pH of cell endosomes and lysosomes are as low as 5.0 and 4.5, respectively. Therefore, pH-responsive drug delivery systems have broad application prospects in biomedicine and other fields, especially anti-tumor fields. [0003] After searching the literature of the prior art, it was found that Yatvin, MB et al. published "pH-Sensitive liposomes: possible clinical implications" in "Science" (Science), No. 210, 1980, page 1253-1255. Plastids: Possible Clin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K9/14A61K47/30A61K47/34A61K47/36A61K47/04A61K47/10A61K47/60
Inventor 车顺爱邢磊
Owner SHANGHAI JIAO TONG UNIV
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