Nested nanostructured electrostatic spinning fiber membrane and preparation method thereof

Abstract

The invention discloses a nested nanostructured electrostatic spinning fiber membrane and a preparation method thereof. The nested nanostructured electrostatic spinning fiber membrane comprises nanofibers and nanoparticles, wherein the nanoparticles are encapsulated in the nanofibers, and the nanofibers and the nanoparticles are all biodegradable materials. The method for preparing the nested nanostructured electrostatic spinning fiber membrane comprises the following steps: uniformly mixing a polymer solution prepared from the nanoparticles and the nanofiber materials; and then carrying out electrostatic spinning on the obtained mixture so as to obtain the nested nanostructured electrostatic spinning fiber membrane the nanoparticles of which are encapsulated in the nanofibers. The structure of the nested nanostructured electrostatic spinning fiber membrane disclosed by the invention is novel and practical; because the electrostatic spinning fiber membrane is in a bilayer nanostructure, the problem of initial burst release existing in the process of loading medicaments in the nanoparticles is effectively solved; and the nested nanostructured electrostatic spinning fiber membrane is simple in preparation method, and has a broad application prospect in nano-medicines, nano-pharmacology and other release fields such as agriculture.

Description

technical field [0001] The invention relates to a nanocomposite material and a preparation method thereof, more specifically, a nested nanostructure composite film and a preparation method thereof. Background technique [0002] The development of nanotechnology provides new concepts for optimal treatment and diagnosis in medicine. Biodegradable nanoparticles have broad application prospects in improving the controlled and targeted release of drugs. Because nanoparticles can enhance the mixing degree of drugs, thereby improving the stability of drugs in the degradation process; they can also achieve targeted release at the target site and reduce side effects. Therefore, the application of nanoparticles as a drug delivery system has been widely used. Research. Of all the colloidal systems, nanoparticles hold the greatest promise to meet the precise control requirements in these delivery systems. Due to biomedical requirements for biocompatibility and biodegradability of mat...

AI Technical Summary

Problems solved by technology

However, the instability of physical and chemical properties in aqueous solution limits the application of biodegradable nanoparticles as drug carriers

[0003] In addition, another problem in the development of nanoparticle drug sustained release system is burst release, that is, it will be released within a few minutes when encountering a medium. Therefore, how to achieve controlled release in a relatively long period of time is a problem worth exploring. topic