Multifunctional biomedical coating material based on traditional Chinese medicine Magnolia officinalis and preparation method thereof

Abstract

The invention discloses a multifunctional biomedical coating material based on the traditional Chinese medicine Magnolia officinalis and a preparation method thereof. 5h, then extracted, spin-dried, and separated by column chromatography to obtain the aldehyde-modified Magnolia officinalis drug, and then dissolved it with a solvent to obtain a drug solution; S2. Polishing, cleaning, and drying the base material, and then placing Add dopamine and polyamine-based compounds to the alkaline buffer solution, react at 10-40° C. for 5-48 hours, and wash to obtain the coating material; S3. Soak the coating material obtained in S2 in the drug solution obtained in S1. React at ~40°C for 1-48 hours, wash and dry to obtain the product. The method of the invention has simple operation, mild and green reaction conditions, does not need large-scale equipment, and the prepared coating surface contains a large amount of magnolia bark medicine.

Description

Multifunctional biomedical coating material based on traditional Chinese medicine Magnolia officinalis and its preparation method technical field The invention belongs to biomedical functional material technical field, relate in particular to a kind of multifunctional raw material based on Chinese medicine Magnolia officinalis Medical coating material and preparation method thereof. Background technique [0002] Blood contact devices include implant / interventional devices (eg stents, arteriovenous grafts, etc.), indwelling needles, extracorporeal circulation Catheters and the like have been widely used in clinical practice. However, blood clots and infections are still the cause of ineffective treatment of blood contact devices and serious clinical symptoms. The main cause of bed incidents also brings great harm to the health and economy of patients. At present, in order to reduce the thrombosis in patients and infection, anticoagulant drugs (such as heparin) and ant...

AI Technical Summary

Problems solved by technology

At present, the use of magnolia bark is taken directly in the form of drugs or systemically administered by injection. The way of taking or systemically administering drugs requires a large dose of drugs, fast drug metabolism and cannot act for a long time, increasing the burden on the liver / kidneys, pregnant women can not Disadvantages such as use and diet need to pay attention

In addition, as a hydrophobic drug, magnolia bark, like most hydrophobic drugs, cannot be dissolved in a single aqueous solvent and assembled on the surface of the material. If the drug is soaked in an organic solvent, the drug is easily released suddenly and cannot achieve long-term The effect of treatment

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