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Bacterium-photothermal nanoparticle composite and preparation method and application thereof

A nanoparticle and composite technology, applied in the field of nanomedicine, can solve problems such as poor treatment effect, achieve the effect of improving safety and targeting, and improving efficiency

Pending Publication Date: 2020-07-03
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] One of the purposes of the present invention is to provide a bacterium-photothermal nanoparticle complex to improve the existing technical problems of using bacteria to treat tumors with poor therapeutic effect

Method used

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  • Bacterium-photothermal nanoparticle composite and preparation method and application thereof
  • Bacterium-photothermal nanoparticle composite and preparation method and application thereof
  • Bacterium-photothermal nanoparticle composite and preparation method and application thereof

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preparation example Construction

[0086] According to a second aspect of the present invention, the present invention provides a method for preparing a bacteria-photothermal nanoparticle complex, comprising the following steps:

[0087] The bacteria and the photothermal nanoparticles are mixed, so that the bacteria and the photothermal nanoparticles are connected by a chemical bond, and a bacteria-photothermal nanoparticle complex is obtained.

[0088] In a typical but non-limiting embodiment of the present invention, both the bacteria and the photothermal nanoparticles are modified with functional groups, and the bacteria and the photothermal nanoparticles are connected by chemical bonds through the interaction between the respective functional groups.

[0089] In the present invention, chemical bonding includes, but is not limited to, ionic bonding, covalent bonding and metal bonding. The method for preparing bacteria-photothermal nanoparticles provided by the invention has simple process, convenient operati...

Embodiment 1

[0117] The present embodiment provides a kind of ICG-PLGA-phospholipid polymer nanoparticles (hereinafter referred to as INPs), which is prepared according to the following steps:

[0118] (1) PLGA is dissolved in acetonitrile to obtain a PLGA solution with a concentration of 2 mg / mL; ICG is dissolved in a mixed solution of ethanol and water (the ethanol concentration is 4%) to obtain an ICG solution with a concentration of 0.75 mg / mL; Soy lecithin is dissolved in the mixed solution of chloroform and methanol (chloroform and methanol volume ratio are 9:1), obtains soybean lecithin solution; DSPE-PEG-COOH is dissolved in the mixed solution of ethanol and water (the ethanol concentration is 4% ), to obtain DSPE-PEG-COOH solution;

[0119] (2) under ultrasonic conditions, soybean lecithin solution, DSPE-PEG-COOH solution and ICG solution are mixed to obtain a mixed solution;

[0120] (3) adding the PLGA solution to the above mixed solution under ultrasonic conditions to obtain I...

Embodiment 2

[0123] The present embodiment provides a kind of INPs, and its preparation method differs from embodiment 1 in that, in step (3), the mass ratio of PLGA, soybean lecithin, DSPE-PEG-COOH and ICG-PLGA nanoparticles is 35:4:3:10.

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Abstract

The present invention provides a bacterium-photothermal nanoparticle composite and a preparation method and an application thereof, and relates to the technical field of nanomedicine. The bacterium-photothermal nanoparticle composite comprises photothermal nanoparticles and bacteria. The bacteria and the photothermal nanoparticles are connected by chemical bonds A technical problem of a poor therapeutic effect of using the bacteria to treat tumors currently is solved. In the provided bacterium-photothermal nanoparticle composite, safety and targeting of the bacteria in body are improved and combination of bacterial therapy and photothermal therapy are combined by chemically bonding the photothermal nanoparticles to the bacteria, and at the same time, the bacterium-photothermal nanoparticlecomposite can also trace and image the bacteria and tumors, and can effectively improve effectiveness of tumor treatment.

Description

technical field [0001] The invention relates to the technical field of nanomedicine, in particular to a bacterium-photothermal nanoparticle composite, a preparation method and application. Background technique [0002] Cancer is a serious threat to human health. The current clinical treatment methods include surgical resection, radiotherapy, chemical drug therapy, and cell therapy and immunotherapy that have sprung up in recent years. Although these treatment methods can prolong the survival period of patients and improve the quality of life, there are still certain limitations. Clinicians and researchers have been tirelessly exploring new treatment methods to provide more options for tumor treatment. [0003] The use of bacteria in cancer therapy dates back to the late nineteenth century, but deliberate attempts to use bacteria to treat inoperable sarcomas have also demonstrated the inherent dangers of the technique. Although the use of bacteria was effective in reducing t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K47/69A61K41/00A61K45/06A61P35/00A61K49/00
CPCA61K35/74A61K41/0057A61K45/06A61K49/0034A61K49/0093A61K47/6935A61P35/00A61K2300/00Y02A50/30
Inventor 刘陈立蔡林涛陈辅明臧中盛陈泽黄建东常志广夏霖曾正阳王伟
Owner SHENZHEN INST OF ADVANCED TECH
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