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Tumor-targeted nanomedicine and application and preparation method

A nano-drug and tumor-targeting technology, applied in the field of tumor-targeting nano-drugs and their application and preparation, can solve the problems of complex drug synthesis process, lack of release specificity, exogenous stimulation, etc., achieving high synthesis efficiency and reducing production The effect of low cost and raw materials

Inactive Publication Date: 2019-11-12
SHENZHEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these nanomedicines require exogenous stimuli, are highly toxic, lack release specificity, and the synthesis process of these drugs is relatively complicated.

Method used

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  • Tumor-targeted nanomedicine and application and preparation method
  • Tumor-targeted nanomedicine and application and preparation method
  • Tumor-targeted nanomedicine and application and preparation method

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preparation example Construction

[0029] The preparation method of described nano medicine comprises the following steps:

[0030] Step 1, using template method to synthesize MSN nanoparticles.

[0031] 2g of CTAC and 0.02g of TEAH were sequentially dissolved in 20ml of deionized water, stirred to fully dissolve. After stirring at room temperature for 10 min, it was transferred to a water bath at 80 °C and stabilized for 30 min. Then, a total of 1.5 ml of tetraethyl orthosilicate was added dropwise, and heating was continued for 1 h under the stirring condition of 400 r / min. The product was collected by centrifugation and washed twice with ethanol to remove additional products of the reaction. The resulting product was then ultrasonically dispersed in 10 mL of deionized water.

[0032] Described Tetraethyl orthosilicate (TEOS), triethanolamine (TEAH), cetyltrimethylammonium chloride (CTAC) are chemical raw materials commonly used in the preparation of this field, all can be ordered from the reagent net.

...

Embodiment 1

[0058] (1) Preparation of MSN nanoparticles.

[0059] 2g of CTAC and 0.02g of TEAH were sequentially dissolved in 20ml of deionized water, stirred to fully dissolve. After stirring at room temperature for 10 min, it was transferred to a water bath at 80 °C and stabilized for 30 min. Then a total of 1.5ml of tetraethyl orthosilicate was added dropwise, and the heating was continued for 1h under the stirring condition of 400r / min. The product was collected by centrifugation and washed twice with ethanol to remove the additional product of the reaction. The resulting product was then ultrasonically dispersed in 10 mL of deionized water to obtain a MSN solution.

[0060] (2) Preparation of MSNs deposited with manganese dioxide in mesoporous channels (MnO 2 @MSN).

[0061] After the above solution was stirred at 40°C for 15min, 10mL KMnO4 aqueous solution (2.5-25mM) was slowly added dropwise under magnetic stirring, and reacted in a water bath at 40°C in the dark for 4h. The p...

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Abstract

The present invention relates to a tumor-targeted nanomedicine and an application and preparation method. The tumor-targeted nanomedicine comprises MSN nanoparticles with mesoporous channels and transition metal oxides and transition metal carbonyl compounds loaded in the mesoporous channels of the MSN nanoparticles. Acid-responsive nano drug (MnO2) is loaded on mesoporous silica channels by the in-situ reduction method, and then drug dodecacarbonyltriiron (Fe3CO12) before gas (CO) release is co-loaded on the mesoporous silica channels through the nano-perfusion method. The preparation processis simple, the cost is low the gas loading efficiency is high, and the nano drug has passive targeting tumor transport and response to release of ROS and CO gas in the tumor microenvironment, low-toxicity and high-efficiency of tumor chemical kinetic therapy and gas therapy are achieved, the therapy efficiency is greatly improved, and clinical application is facilitated.

Description

technical field [0001] The invention relates to the technical field of nanomedicine diagnosis and treatment preparations, in particular to a tumor-targeted nanomedicine and its application and preparation method. Background technique [0002] Chemotherapy is the main method for clinical treatment of cancer, especially advanced cancer, and is an effective systemic treatment. However, at present, most chemotherapeutic drugs have no specific recognition, are easy to damage normal cells and tissues, and even cause systemic poisoning, and the drug uptake efficiency of tumor cells is low, and repeated administration can easily lead to drug resistance of tumor cells. Currently, nano-drug delivery systems are used to target chemotherapy drugs into tumor cells, thus solving the problem of efficient and directional delivery of chemotherapy drugs. However, there will still be drug leakage during the delivery of chemotherapy drugs, and the toxic and side effects of chemotherapy usually...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/04A61K33/32A61K33/26A61P35/00
CPCA61K9/5115A61K33/26A61K33/32A61P35/00A61K2300/00
Inventor 何前军招斌赵鹏赫金召奎范明检孟晋温艳媛
Owner SHENZHEN UNIV
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