The invention discloses a method for evaluating the adsorption performance of a blood
perfusion device to
bilirubin. The method comprises the following steps: obtaining a hyperbilirubinemia rabbit model; and performing blood
perfusion on the obtained hyperbilirubinemia rabbit model by using a blood
perfusion device, calculating the adsorption rate of the blood perfusion device on
bilirubin, and evaluating the adsorption performance of the adsorbent. According to the hyperbilirubinemia
animal model, a rabbit is selected as a modeling object, the rabbit is subjected to
intragastric administration with an induction
reagent twice, and the hyperbilirubinemia rabbit model is obtained; the induction
reagent is alpha-naphthyl
isocyanate; the administration dosage of the induction
reagent during the second time of
intragastric administration is greater than that of the induction reagent during the first time of
intragastric administration. According to the method, the
animal model meeting the requirement for evaluating the adsorption performance of the
bilirubin of the adsorbent in a perfusion mode can be rapidly established, the modeling method is simple and rapid, the modeling cost is low, the model
operability is high, the adsorption performance of the adsorbent evaluated in the perfusion mode is closer to the clinical practical application condition, and the more accurate and
objective evaluation effect is achieved.