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Flexible mesoporous organosilicone nanorods and preparation method and application thereof

A mesoporous silicone and nanorod technology, applied in the field of mesoporous silica materials, can solve the problems of unstable properties of non-spherical nanoparticles, unfavorable application of flexible nanoparticles, and limitation of nanoparticle loading, etc., and achieve good polar solvent dispersion Effects of performance and biocompatibility, uniform size, low equipment requirements

Active Publication Date: 2019-05-21
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Compared with spherical nanoparticles, non-spherical nanoparticles are more unstable in thermodynamics, so most of the flexible nanoparticles reported at this stage are spherical or quasi-spherical, and a single shape is not conducive to the application of flexible nanoparticles in bio- In addition, most of the flexible nanoparticles reported in the past do not have a mesoporous structure, which limits the loading of nanoparticles on therapeutic molecules, which is not conducive to the further development of flexible nanoparticles in the field of biomedicine. application
[0003] So far, the preparation and development of non-spherical flexible mesoporous nanoparticles has not been reported, and the preparation of such nanoparticles is still a challenging task.

Method used

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  • Flexible mesoporous organosilicone nanorods and preparation method and application thereof
  • Flexible mesoporous organosilicone nanorods and preparation method and application thereof
  • Flexible mesoporous organosilicone nanorods and preparation method and application thereof

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Embodiment 1

[0033] Example 1, Preparation of Flexible Mesoporous Silicone Nanorods

[0034] Step S1, the preparation of gold nanorods adopts the seed crystal induced growth method, and the specific preparation scheme is as follows:

[0035] (1) Synthesis of nano-gold seed solution: All synthesis experiments were completed in a water bath, and the temperature of the water bath was controlled at 30 °C; first, the prepared 0.01 M sodium borohydride (0.0189 g dissolved in a 50 mL volumetric flask) was placed on ice Put the reaction bottle in a water bath at 30-32°C, and add magnetite, chloroauric acid (0.25 mL, 0.01 M), cetyltrimethylammonium bromide (10 mL, 0.1 M ), stirring, and finally adding the reducing agent sodium borohydride (0.6 mL, 0.1 M); stirring for three minutes, and standing for 0.5 h, the reaction solution was brown at this time;

[0036] (2) Synthesis of nano-gold rods—growth of nano-gold species: all synthesis experiments were completed in a water bath, and the temperature ...

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Abstract

The invention discloses flexible mesoporous organosilicone nanorods and a preparation method and application thereof. The flexible mesoporous organosilicone nanorods have a stick-like morphology, crimping surfaces, large internal cavities and mesoporous channels; during preparation, gold nanorods are used as an inner core, a flexible mesoporous organic silicon oxide shell layer is obtained throughetching of an alkaline solution, and a skeleton contains organic silicon oxide and inorganic silicon oxide at the same time. The preparaiton technology process of the flexible mesoporous organosilicone nanorods is simple, the finished product is lower in Young modulus and higher in cytophagy efficiency, and the flexible mesoporous organosilicone nanorods have a great application potential in thefields of drug delivery, nanometer medical imaging and the like.

Description

technical field [0001] The invention belongs to the field of mesoporous silicon oxide materials, in particular to a flexible mesoporous organic silicon nanorod and its preparation method and application. Background technique [0002] In recent years, flexible nanoparticles have gained increasing attention in the biomedical field due to their unique biological properties, including long in vivo circulation time and high cellular uptake efficiency. Compared with spherical nanoparticles, non-spherical nanoparticles are more unstable in thermodynamics, so most of the flexible nanoparticles reported at this stage are spherical or quasi-spherical, and a single shape is not conducive to the application of flexible nanoparticles in bio- In addition, most of the flexible nanoparticles reported in the past do not have a mesoporous structure, which limits the loading of nanoparticles on therapeutic molecules, which is not conducive to the further development of flexible nanoparticles i...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K49/00
Inventor 滕兆刚陈昆苏晓丹汪联辉冯志浩
Owner NANJING UNIV OF POSTS & TELECOMM
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