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Lipofectin nanometer silver gel and preparation method thereof

A nano-silver gel and liposome technology, used in liposome delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Active Publication Date: 2013-04-03
ZHEJIANG SANHE NANOMETER SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nano-silver is easily inactivated or easily oxidized, so that the existing nano-silver antibacterial agents are generally brown or black, which seriously affects the antibacterial effect of the preparation and the appearance of white or light-colored products, restricting its application in a wider range
[0006] related nano-silver preparations and materials reported in the literature have varying degrees of instability to light and heat, larger particle sizes, complex and time-consuming preparation processes, and Problems such as viscosity drop and discoloration over time
[0007] Although liposome gel has been reported (for example, the People's Republic of China Invention Patent Application No. 20121004182.1 discloses a liposome gel preparation and its preparation methods and uses), but the preparation of nano-silver into liposome gel has not been reported so far

Method used

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  • Lipofectin nanometer silver gel and preparation method thereof
  • Lipofectin nanometer silver gel and preparation method thereof
  • Lipofectin nanometer silver gel and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Chitosan 3 parts

[0030] Glycerin 8 parts

[0031] 1 part peppermint oil

[0032] 40 parts of acetic acid solution

[0033] Nano silver solution 40 parts

[0034] After mixing soybean lecithin and cholesterol (mass ratio: 5:1) in a ratio of 2.5 parts, dissolve it in an appropriate amount of organic solvent ether, remove the organic solvent at 60°C to make the lipid form a film on the inner wall, and pour it into a round bottom flask Add 40 parts of nano-silver solution (silver content is 50-380ppm), stir and hydrate for 1 hour, wash the film, add deionized water to constant volume, and ultrasonicate for 20 minutes; the A-component liposome nano-silver is obtained. Weigh 3 parts of chitosan, add 40 parts of acetic acid solution with a pH of 3-5, swell at room temperature for 12 hours to make it a uniform viscous solution, add deionized water to constant volume; the gel of component B is obtained. Add the prepared nano-silver liposomes into the swollen chitosan solut...

Embodiment 2

[0037] Chitosan 3.5 parts

[0038] Glycerin 10 parts

[0039] 0.7 parts of peppermint oil

[0040] 55 parts of acetic acid solution

[0041] Nano silver aqueous solution 35 parts

[0042] After mixing soybean lecithin and cholesterol (mass ratio 3:1) at a ratio of 2.9 parts, dissolve it in an appropriate amount of organic solvent chloroform:ether=4:1 mixture, and remove the organic solvent at 60°C to make the lipid Form a film on the inner wall, add 35 parts of nano-silver solution (50-380ppm silver content) to the round bottom flask, stir and hydrate for 1 hour, wash the film, add deionized water to volume, and ultrasonic treatment for 40 minutes; to obtain group A Liposome nano silver. Weigh 3.5 parts of chitosan, add 55 parts of acetic acid solution with a pH of 3-5, swell at room temperature for 12 hours to make it a uniform viscous solution, add deionized water to constant volume; and obtain component B gel. Add the prepared nano-silver liposomes into the swollen chi...

Embodiment 3

[0045] Chitosan 5 parts

[0046] Glycerin 15 parts

[0047] 1.5 parts peppermint oil

[0048] 45 parts of acetic acid solution

[0049] Nano silver solution 50 parts

[0050]After mixing soybean lecithin and cholesterol (mass ratio 7:1) in a ratio of 3.5 parts, dissolve it in an appropriate amount of organic solvent chloroform: ether = 4:1 mixture, and remove the organic solvent at 30°C to make the lipid Form a film on the inner wall, add 50 parts of nano-silver solution (50-380ppm silver content) into the round bottom flask, stir and hydrate for 3 hours, wash the film, add deionized water to volume, and ultrasonically treat for 30 minutes; to obtain component A Liposome nanosilver. Weigh 5 parts of chitosan, add 45 parts of acetic acid solution with a pH of 3-5, swell at room temperature for 12 hours to make it a uniform viscous solution, add deionized water to constant volume; the gel of component B is obtained. Add the prepared nano-silver liposomes into the swollen ch...

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Abstract

The invention relates to a lipofectin nanometer silver gel and a preparation method of the lipofectin nanometer silver gel. The lipofectin nanometer silver gel is prepared from the following raw materials in parts by weight: 1.5 to 4.5 parts of soya bean lecithin and cholesterol, 1 to 9 parts of chitosan, 1 to 20 parts of glycerol, 0.1 to 2 parts of oleum menthae, 30 to 70 parts of acetum, 20 to 60 parts of nanometer silver solution, and the balance of deionized water. According to the preparation method, the nanometer silver is prepared into lipofectin, most of the nanometer silvers are encapsulated in a bilayer formed by the lipofectin, and therefore the stability of the nanometer silver can be improved; and the proper macromolecular optimum formula is adopted to prepare the gel, thus the convenience is provided for paving medicine on the skin. The prepared preparation has the advantages of being stable in medicine release rate, convenience in medicine paving, low in frequency of using the medicine, free from toxicity and stimulation and high in compliance of a user, and can be used for preventing and treating skin intolerance caused by various pathogenic microorganisms.

Description

technical field [0001] The present invention relates to a liposomal nano-silver gel and a preparation method thereof, in particular to a liposomal nano-silver gel which has broad-spectrum antibacterial activity and is used for treating skin discomfort caused by pathogenic bacteria. Liposome nano silver gel and preparation method thereof. Background technique [0002] Antibacterial agents can be divided into two types according to their materials: organic antibacterial agents and inorganic antibacterial agents. Silverware has been used since ancient times to store food and prevent bacterial growth. Silver was used to speed wound healing, treat infections, purify water and preserve beverages. However, the instability of silver ions in solution limits its popularization and application. [0003] According to domestic and foreign research reports, nano-silver prepared by combining nano-materials and technology with the antibacterial effect of silver has special properties of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K33/38A61P31/02A61P17/00
Inventor 毕小平张文正金伟赵正保李芸
Owner ZHEJIANG SANHE NANOMETER SCI & TECH
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