30results about How to "Stable during storage" patented technology

Disclosed in certain embodiments is a pharmaceutical composition comprising from 10 to 40 mg of oxycodone or a pharmaceutically acceptable salt thereof and 0.65 to 0.90 mg naloxone or a pharmaceutically acceptable salt thereof.

The invention concerns excipients or combinations thereof suitable for preparing an oral formulation containing a pharmaceutical agent. More particularly, the invention is directed to stable, efficacious and bioavailable oral pharmaceutical formulations comprising paclitaxel, derivatives of paclitaxel and pharmaceutically acceptable salts thereof. The formulations of the invention increase bioavailability of paclitaxel when dissolved in the gastrointestinal system. The formulations of the invention are useful for administering paclitaxel, its derivatives, or pharmaceutically acceptable salts of such derivatives to patients in need thereof. The formulations of the invention are particularly suitable for oral administration to mammals including humans.

The invention discloses a moxifloxacin aqueous solution type injection which contains moxifloxacin or pharmaceutically acceptable salt, weak acid sodium salt or phosphoric acid sodium salt and water for injection, wherein the content of the moxifloxacin is 0.8-4 percent (g / ml), and the molar concentration of the weak acid sodium salt or the phosphoric acid sodium salt is 0.0002-1mol / L. The moxifloxacin aqueous solution type injection product has strong dissolubility, human body acceptable pH value, easier control of product quality, stability in a storage period, good compatibility with clinical common isotonic solution, low production cost, small volume and convenient transportation and storage.

A hardmask composition for forming a resist underlayer film, a process for producing a semiconductor integrated circuit device, and a semiconductor integrated circuit device, the hardmask composition including an organosilane polymer, and a stabilizer, the stabilizer including one of acetic anhydride, methyl acetoacetate, propionic anhydride, ethyl-2-ethylacetoacetate, butyric anhydride, ethyl-2-ethylacetoacetate, valeric anhydride, 2-methylbutyric anhydride, nonanol, decanol, undecanol, dodecanol, propylene glycol propyl ether, propylene glycol ethyl ether, propylene glycol methyl ether, propylene glycol, phenyltrimethoxysilane, diphenylhexamethoxydisiloxane, diphenylhexaethoxydisiloxane, dioctyltetramethyldisiloxane, hexamethyltrisiloxane, tetramethyldisiloxane, decamethyltetrasiloxane, dodecamethylpentasiloxane, hexamethyldisiloxane, and mixtures thereof.

The subject of the invention is a fiber-enriched low-calorie drink, characterized in that it comprises 1.5 to 90 g, by dry weight per liter of drink, or branched maltodextrins having between 15 and 35% of 1→6 glucoside linkages, a reducing sugar content of less than 20%, a polymolecularity index of less than 5 and a number-average molecular mass Mn at most equal to 4 500 g / mol, and in that it is stable to acidic pH and / or to heat. The subject of the invention is also the use of branched maltodextrins having between 15 and 35% of 1→6 glucoside linkages, a reducing sugar content of less than 20%, a polymolecularity index of less than 5 and a number-average molecular mass Mn at most equal to 4 500 g / mol, in order to replace all or part of the sugars in a low-calorie drink.

The invention discloses a microbial weeding oil flowable concentrate for rice field, which is characterized by taking Curvularia lunata (Wakker) Boedijn B6 with the preservation number of CGMGG No. 2928 as an effective component, being complemented by suitable solvent, surfactant, thickener and stabilizer, and then preparing a suspension system after mechanical grinding, wherein the effective component is (0.1-10)*108 spores / ml, the mass percentage of the surfactant is 1-10, the mass percentage of the stabilizer is 1-10, the mass percentage of the thickener is 0.1-5, and the solvent is filled in to 100 percent; the oil-based suspension is used for preventing and weeding barnyard grass in the rice field and is safe for the rice, and can control the barnyard grass of a whole rice growth period by using the microbial weeding oil-based suspension once; and the invention provides a novel formulation of an effective post-sprout microbial herbicide with stable storage, and the microbial weeding oil flowable concentrate is environmental-friendly, prevents and weeds the barnyard grass in the rice field and increases the yield obviously.

A consumable food composition is provided containing rice hull particles or blends of rice hull particles and bran. The food compositions have excellent fiber content and are advantageously nutritious.

The invention belongs to the field of medicinal preparations, and relates to an etoposide long-circulating emulsion for injection, and a preparation method thereof. The etoposide long-circulating emulsion comprises etoposide, fluid oil, emulsifiers, polyethylene glycol (PEG) modified esters and the like, and has the characteristics of high entrapment rate, good stability and low toxicity. The etoposide long-circulating emulsion improves the solubility and the stability of etoposide, reduces irritation effects of etoposide on blood vessels, prolongs cycle time of etoposide in blood, and improves distribution of etoposide in vivo thus improves drug curative effects. The preparation method of the etoposide long-circulating emulsion solves the carrying problems of drugs with poor water-solubility and fat-solubility and realizes stable preservation and no drug precipitation. The preparation method has the characteristics of simple process, low cost and good applicability for industrializedproduction.

A heat-curable ink composition and a color filter produced using the ink composition are provided. The ink composition and the color filter are highly resistant to heat and chemicals due to the use of a polyester resin prepared by polycondensation. In addition, unreacted anhydride groups are removed using a monohydric alcohol in the preparation of the ink composition to make the ink composition and the color filter very stable during storage.

The present invention provides an antimicrobial nanometer composition and a preparation method thereof. The composition is a solution preparation, can be provided for effectively killing bacteria, fungi, viruses and even various drug-resistance bacteria, has characteristics of no irritating on skin and mucous membrane and high safety, can be used for treatment and prevention of infectious diseases on skin and mucous membrane sites, and can further be used for skin and mucous membrane cosmetics. The antimicrobial organic nanometer composition has the following advantages that: 1) the product has high safety, and the production cost is low; 2) the raw materials belong to the generally accepted safe materials, and the sources are wide; and 3) characteristics of no toxicity, no irritating and no drug resistance generation are provided.

The present invention concerns a dispersion of crystals or granules of active substance in a lipophilic vehicle, said crystals or granules being coated by a coating for taste masking purposes. The invention also it concerns unit dosage forms and preferentially chewable or fast dissolving soft gelatin capsules filled with said dispersion as well as process for manufacturing same.

The invention provides novel liquid lansoprazole formulations comprising lansoprazole and an excipient system, wherein: (a) the concentration of lansoprazole in the formulations ranges from about 0.3 mg / mL to about 50 mg / mL; (b) the excipient system comprises either a single excipient, or a combination of two to four compositionally distinct excipients; and (c) the formulations may be administered parenterally to a mammal to treat or prevent a gastrointestinal disorder.

A novel probiotic active matter transmission system used for skincare cosmetics and a preparing method thereof are provided. The system is a phospholipid microcapsule ultramicron particle solution preparation, can effectively increase stability of probiotic active matters, can enter skin directionally through hair follicle channels, has multiple targeting properties and is capable of effectively improving active matter absorption and utilization of the skin, nonirritant to human skin and high in safety. The system can be used for cream, essence, emulsion, gel, and other skincare cosmetics. The system is advantageous in that 1) a product is high in safety, a preparing process is simple and a production process is free of heating treatment, 2) raw materials are generally recognized as safe and wide in source, and 3) biocompatibility is good and the system is nontoxic, non-irritant and good in skin sense.

The invention relates to an Albizzia julibrissin Durazz. endophytic bacterium H6 ferment suspended seed coating, and a preparation method thereof, through which such technical problems of the conventional biological agents as high cost, environmental pollution and inconvenience in storage can be solved. The suspended seed coating comprises the following components according to weight percentages:10-25% of Albizzia julibrissin Durazz. endophytic bacterium H6 ferment spray drying powders, 3-10% of a wetting agent, 0.1-5% of a thickening agent, 1-5% of a film-forming agent, 1-5% of an anti-freezing agent, 1-10% of a stabilizing agent, 0.1-8% of a thickening agent, 0.1-3% of a coloring agent, 0.1-2% of a defoaming agent, and water. The invention further provides the preparation method of theAlbizzia julibrissin Durazz. endophytic bacterium H6 ferment suspended seed coating. The Albizzia julibrissin Durazz. endophytic bacterium H6 ferment suspended seed coating and the preparation methodthereof can be widely applied in the field of biological fungicides.

The invention belongs to the technical field of food processing, particularly relates to a seasoning with the flavor of boiled fish with pickled cabbages and chili and a preparation method of the seasoning. The seasoning with the flavor of boiled fish with pickled cabbages and chili is prepared from raw materials in parts by weight as follows: fish sauce flavored pickled cabbages, a pickling seasoning and a condiment in the ratio being (1-6): (1-4): (1-4). The fish sauce flavored pickled cabbages are obtained by cutting and drying green vegetables, adding salt to pickle the dried vegetables, adding a fish sauce enzymatic hydrolysate and salt in proportion, conducting sealed pickling and particularly conducting low-temperature plasma sterilization. The fish sauce enzymatic hydrolysate is prepared by selecting fish bones with little fish, mincing the fish bones, adding enzymes in the specific proportion and specific composition and conducting preparation with a secondary enzyme addition method. The condiment is processed through traditional stir-frying in combination with the flash evaporation technology, and the pickling seasoning is processed by adding all the ingredients under ultrasonic assistance. The seasoning with the flavor of boiled fish with pickled cabbages and chili can be applied to processing of meat or meat substitutes, snack food, vegetables and cooked wheaten food.

The subject invention provides methods and / or processes for making stereoisomeric compounds of formula (X): wherein the variables are as defined herein, and compositions for the safe and effective treatment of various gastrointestinal disorders including, but not limited to, gastroparesis, gastroesophageal reflux and related conditions. The compounds of the subject invention are also useful in treating a variety of conditions involving the central nervous system.

The invention belongs to the field of pharmaceutical preparations, and particularly discloses a liquid preparation of an immunosuppressor monoclonal antibody, the liquid preparation provided by the invention comprises an anti-CD20 human-mouse chimeric monoclonal antibody, a buffer solution system, a stabilizer, a solubilizer and the like, the anti-CD20 human-mouse chimeric monoclonal antibody provided by the invention is better in stability and lower in aggregate, and the protein storage time is effectively prolonged.

The invention belongs to the field of medicinal preparations, and relates to an etoposide long-circulating emulsion for injection, and a preparation method thereof. The etoposide long-circulating emulsion comprises etoposide, fluid oil, emulsifiers, polyethylene glycol (PEG) modified esters and the like, and has the characteristics of high entrapment rate, good stability and low toxicity. The etoposide long-circulating emulsion improves the solubility and the stability of etoposide, reduces irritation effects of etoposide on blood vessels, prolongs cycle time of etoposide in blood, and improves distribution of etoposide in vivo thus improves drug curative effects. The preparation method of the etoposide long-circulating emulsion solves the carrying problems of drugs with poor water-solubility and fat-solubility and realizes stable preservation and no drug precipitation. The preparation method has the characteristics of simple process, low cost and good applicability for industrializedproduction.

The present invention relates to the formulation of midazolam. In particular, the invention provides new midazolam formulation for intranasal administration. These formulations contain midazolam in a high concentration from about 1% to about 10% w / w of the formulation and process of preparation thereof.

New ultrasound contrast agents that comprise microbubbles encapsulating a gas within a shell made from a blend of bipolar compounds having mixed carbon chain length. The compounds have hydrophobic groups selected from the group consisting of straight-chained alkyls, alkylethers, alkylthiolethers, alkyldisulfides, polyfluoroalkyls, and polyfluoroalkylethers having a carbon chain length greater than or equal to 16 and less than or equal to 32. The polar groups are connected to the hydrophobic groups by means of a linker. The polar head groups are selected from the group consisting of CO2-M+, SO3−M+, SO4−M+, PO3−M+, PO4−M+2, N(R)4+, a pyridinium or substituted pyridinium group, and a zwitterionic group; R is selected from the group consisting of —H, —CH3, alkyl, cycloalkyl, substituted cycloalkyls containing one or more heteroatoms, and benzyl and can be the same or different; and Z′ is a nonionic and M is a cation.