Topical composition for the treatment of actinic keratosis

A technology of actinic keratosis and composition, which is applied in the direction of drug combination, allergic disease, skin disease, etc., to achieve the effect of rapid absorption or drying and high pharmacological availability

Inactive Publication Date: 2011-06-08
ALMIRALL HERMAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been found that topical administration of compositions comprising these levels of 5'-fluorouracil elicits a number of side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0041] A product with the following composition (wt%) was prepared:

[0042] 5’-Fluorouracil

example 2

[0044] A product with the following composition (wt%) was prepared:

[0045] 5’-Fluorouracil

[0046] Dimethyl sulfoxide

example 3

[0048] A product with the following composition (wt%) was prepared:

[0049] 5’-Fluorouracil

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PUM

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Abstract

The invention relates to a topical gel composition comprising (a) an active agent for treatment of actinic keratosis, (b) a keratolytically active agent, (c) a gel former and (d) an organic solvent for use in the treatment of actinic keratosis.

Description

Technical field [0001] The present invention relates to a topical composition used as a medicine for treating actinic keratosis. Background technique [0002] Actinic keratosis is a kind of epidermal carcinoma in situ. It is related to the proliferation of transformed keratinocytes confined to the epidermis, and is characterized by high mutation rates of the tumor suppressor genes p53 and telomerase genes in particular. It is further associated with characteristic chromosomal aberrations that also commonly occur in invasive cutaneous squamous cell carcinoma. In about 10% of all patients suffering from actinic keratosis, especially about 30% of patients also suffering from immunosuppression, the condition will become squamous cell carcinoma of the skin during the further development of the condition. Therefore, the diagnosis of actinic keratosis usually constitutes an indicator of treatment. [0003] In the treatment of actinic keratosis, different surgical and physical methods s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/196A61K31/513A61K31/60A61P17/12
CPCA61K47/32A61K31/513A61K31/196A61K45/06A61K9/0014A61K31/60A61K9/06A61P17/00A61P17/02A61P17/12A61P35/00A61P37/02A61P43/00A61K2300/00
Inventor M·迈泽尔C·马蒂斯K·图德勒C·威勒斯H·马尔维茨
Owner ALMIRALL HERMAL
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