The invention discloses a novel stomatological-department instrument disinfection cabinet. The instrument disinfection cabinet structurally comprises a disinfection protection top cover, an indicationlamp, an adjusting vent hole, a side protection side frame, a control switch, an exhausting and draining device, a tank door protection side frame, a support base, a front-mounted protection shell, atank door handle switch, a protection tank door, a control panel, a display panel and an upper protection limiting plate, wherein the lower end of the adjusting vent hole is arranged on the front side of the upper end of the disinfection protection top cover, and the lower ends of the left and right ends of the disinfection protection top cover are welded to the upper end of the side protection side frame. The novel stomatological-department instrument disinfection cabinet has the beneficial effects that by adding the exhausting and draining device on the cabinet, during disinfection of the stomatological-department instrument, when the stomatological-department instrument is washed or flushed, the airing and drying of instruments can be accelerated, so that the disinfection of the stomatological-department instruments can be rapidly carried out, the practicability of the equipment is high, and the disinfection efficiency of the instruments is improved; and the disinfection cabinet isrelatively practical.