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A novel probiotic active matter transmission system used for skincare cosmetics and a preparing method thereof

A technology for skin care cosmetics and delivery system, which is applied in the field of probiotic active substance delivery system and its preparation, can solve the problems of high efficacy requirements, unstable active ingredients, and difficulty in fully exerting the efficacy of active substances, and achieves a simple preparation method and a storage period. Maintain stability and good biocompatibility

Active Publication Date: 2016-11-30
琦雅日化(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the above traditional carriers, the efficacy of active substances is often difficult to fully exert, and the requirements for efficacy are higher, and they contain unstable active ingredients, such as vitamins and peroxides. This simple method cannot meet the requirements.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Accurately weigh 155mg of lactic acid (COFCO), dissolve it in an appropriate amount of pure water, stir to dissolve completely, adjust the pH to 6.5, and set the volume to 100ml. Weigh 0.5g of yogurt extract (Texas Anglida), dissolve it with 4.5ml 10mM pH3.5 citric acid, stir well, filter it with double-layer filter paper, take the supernatant, and dissolve it with sodium citrate solution Its pH is adjusted to 6.5. Weigh 10g and 15g of brewer's yeast extract (Angelica yeast) and lactic acid bacteria North American Holy Grass extract (Active Concepts) respectively, mix with the supernatant of yogurt extract, and stir evenly with high-speed shearing to obtain a probiotic active substance solution. Weigh 20 g of prephospholipid microcapsules (PuriBio Biomedical Technology Co., Ltd., PuriBio), mix it evenly with the probiotic active substance solution, slowly inject it into 50 g of histidine buffer under high-speed stirring, and stir at high speed to obtain Phospholipid mi...

Embodiment 2

[0029] skin irritation test

[0030]Select 6 healthy New Zealand rabbits with no skin damage, weighing 2.5±0.3kg, 3 rabbits in each group. 24 hours before the test, the skin on both sides of the middle spine of the rabbit’s back is depilated. The depilatory area on each side is preferably about 2cm×3cm. The bare skin on one side was coated with 0.5 g of antimicrobial nano-combination probiotic active phospholipid microcapsules, covered with gauze, and fixed with adhesive tape; the skin on the other side was coated with an equal amount of distilled water as a control, and the application time was 4 hours. After 4 hours of drug application, the drug administration sites on both sides were washed with warm physiological saline, and the skin reactions of the drug application sites were observed after 1, 24 and 48 hours of removal of the test substance, respectively. The results showed that there was no erythema or edema on both sides of the skin during each observation period, and...

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Abstract

A novel probiotic active matter transmission system used for skincare cosmetics and a preparing method thereof are provided. The system is a phospholipid microcapsule ultramicron particle solution preparation, can effectively increase stability of probiotic active matters, can enter skin directionally through hair follicle channels, has multiple targeting properties and is capable of effectively improving active matter absorption and utilization of the skin, nonirritant to human skin and high in safety. The system can be used for cream, essence, emulsion, gel, and other skincare cosmetics. The system is advantageous in that 1) a product is high in safety, a preparing process is simple and a production process is free of heating treatment, 2) raw materials are generally recognized as safe and wide in source, and 3) biocompatibility is good and the system is nontoxic, non-irritant and good in skin sense.

Description

technical field [0001] The invention belongs to the field of cosmetics. Specifically, the invention relates to a novel probiotic active substance delivery system for skin care cosmetics and a preparation method thereof. Background technique [0002] The development of functional cosmetics is inseparable from functional cosmetic raw materials, and the development of raw materials is closely related to the development of life sciences. As consumers continue to increase their requirements for skin care products, which not only have functions such as cleansing and moisturizing, but also hope to remove wrinkles and enhance skin elasticity, cosmetics manufacturers have begun to use natural actives in large quantities. Natural active cosmetic raw materials refer to cosmetic raw materials made by extracting and separating compounds with unique functions and biological activities from natural raw materials through fine chemical and biochemical technologies. For many years, cosmetics...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/55A61Q19/00
Inventor 施协均
Owner 琦雅日化(上海)有限公司
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