45results about How to "Reduce Potential Toxicity" patented technology

Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.

The invention discloses hydrobromide of benzodiazepine derivative and multiple crystal forms thereof, and a preparation method for the multiple crystal forms. The preparation method comprises the following steps: heating and dissolving hydrobromide of the crystal form or amorphous form of a compound as shown in a formula (I) which is defined in the specification or the compound as shown in the formula (I) and a hydrobromic acid solution in a crystallization solvent; carrying out cooling and crystallization; and then carrying out washing and drying so as to prepare hydrobromide of the compound as shown in the formula (I) or the crystal forms thereof. The prepared hydrobromide of the compound as shown in the formula (I) has good stability, high purity and no toxicity and can be better applied to clinical treatment.

The invention discloses a method of preparing humus and recovering heavy-metal-polluted bottom mud with the humus. Green waste, wood dust, bean pulp, humus soil and / or grape residues are proportionedon the basis of the compost raw material mass proportion of (4.5-5.5):(1.8-2.2):1:(1.8-2.2):(1.8-2.2), wherein the green waste is one or more of peanut straws, corn straws, sesame straws and maple leaves; a C / N mass ratio and moisture content are adjusted, white-rot fungi and trichoderma viride are inoculated, and aerobic composting is conducted; after composting, the humus in the mixture is extracted. According to the method of preparing humus and recovering the heavy-metal-polluted bottom mud with the humus, the polluted bottom mud is leached with a humus solution to remove heavy metal and complete a recovery process. The humus in an extractable state generated through green waste composting serves as a leaching agent, which makes the method more efficient and environmentally friendly, no new heavy metal pollution can be generated, the cost is low, and humus generation through composting achieves waste recycling better.

The invention relates to a novel class of inhibitor of arachidonic acid useful for treating inflammatory conditions. Specifically, the invention relates to hydrophobic and hydrophilic derivatives of sesamol that confer lower toxicity and increased circulatory lifetimes than pure sesamol.

The invention relates to a novel optical isomer compound of a formula (1), in particular to a dextroisomer of ibuprofen guaiacol ester. The invention also discloses a method for preparing the compound, a drug composition taking the compound as an active ingredient and application of the compound and the drug composition to the preparation of drugs of diminishing inflammation, effectively alleviating various pain or having effects of relieving fever of adults and / or children.

A delivery system and preparation of siRNA, with nanoparticles enclosing siRNA as an active ingredient, wherein the nano-particles are formed by a polymer and a cationic lipid, the polymer is a di-block or tri-block copolymer of polyethylene glycol-polylactic acid or polyethylene glycol-poly(lactic acid-glycolic acid), the cationic lipid is N,N-dihydroxyethyl-N-methyl-N-2-(cholesteroloxy carbonylamino) ethylammonium bromide or (2,3-dioleyloxy propyl) trimethylammonium chloride. The nanoparticle and preparation can desirably deliver siRNA to a cell and effectively silence expression of a target gene. Moreover, after being modified by a ligand or antibody, the siRNA delivery system can desirably silence the target gene at both a cellular level and an animal level.

A pesticide composition includes an active component and polyethyleneimine having a weight average molecular weight of at least about 750,000 g / mol and has improved rainfastness. The polyethyleneimine of this invention has decreased mobility in water as compared to related lower molecular weight analogs. The pesticide composition is formed using a method that includes the steps of providing the active component, providing the polyethyleneimine, and combining the active component and the polyethyleneimine to form the pesticide composition.

The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype Ia conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype Ib conjugated to a carrier protein; c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein; d) a conjugate that is a capsular saccharide from GBS serotype II conjugated to a carrier protein; and e) a conjugate that is a capsular saccharide from GBS serotype V conjugated to a carrier protein.

The invention relates to the field of biomedicine, especially to a drug-loaded tissue adhesive film and a preparation method thereof. The invention provides a drug-loaded tissue adhesive film, which comprises alternately superimposed cationic layers and anionic layers, at least one layer of the cationic layers and anionic layers is a drug layer, or at least one layer of the cationic layers and anionic layers contains a charged drug. The drug-loaded tissue adhesive film provided by the invention has good tissue adhesiveness, good biocompatibility and degradable absorbability, and good stability, and the physical and chemical properties of the drug-loaded tissue adhesive film can be adjusted by regulating the material composition.

The invention discloses a nano-silver color developing system for responding to a rot smell of meat through color change, and a preparation method and an application thereof, and belongs to the fieldof food monitoring. According to the color developing system, an Arabic gum powder solution is added into a silver nitrate solution and the solutions are stirred uniformly; then a reaction is carriedout under a high-temperature and high-pressure condition; and after the reaction is ended, filtering is carried out to obtain the Arabic gum powder-nano-silver color developing system. Compared with atraditional nano-silver preparation method, the preparation method has the following advantages: the preparation method of the Arabic gum powder-nano-silver color developing system which follows "green chemistry" shows the advantages of safety, non-toxicity, environmental friendliness and the like, and greatly reduces the toxic effect generated by the traditional preparation method. By selectinga food-grade safe medium, the potential toxicity generated for the environment and organisms is reduced. Meanwhile, certain harm to the environment caused by toxic substances generated in a synthesisprocess is avoided.

The invention relates to an extraction method of longan seed polyphenol, relating to a processing method of a longan. The extraction method of the longan seed polyphenol can enhance the economic benefit of a longan industry and increase the income of fruit growers. The extraction method of the longan seed polyphenol comprises the following steps of: drying cleaned longan seeds; smashing raw material longan seeds to obtain longan seed powder; adding a sodium phosphate buffer solution to the longan seed powder to obtain a leach solution; pouring out the leach solution, filtering, removing leaching residues, and recovering immersion liquid; concentrating obtained filter liquor to obtain a concentrated solution; adding hydrochloric acid to the concentrated solution, stirring, and then standing for precipitation to obtain a precipitation solution; centrifugalizing the precipitation solution, removing a supernatant, washing precipitates by using the hydrochloric acid, and then drying to obtain fine longan seed polyphenol powder.

The invention discloses the preparation and application of a polydopamine-encapsulated mesoporous silica nanometer drug-carrying system, which belongs to the application development of nanotechnology in the agricultural field. The nano-drug loading system uses mesoporous silica nanoparticles as the carrier of the pesticide, and is formed by encapsulating polydopamine after adsorbing the pesticide. The nano-drug loading system described in the present invention has pH responsiveness and can promote the release of loaded pesticide molecules under alkaline conditions. The nano-drug-loading system has good photothermal conversion ability. Under the irradiation of near-infrared light, the temperature of the system is increased, which is beneficial to the release of pesticide components. Through the encapsulation of polydopamine, the nano-drug-loading system has good leaf adhesion properties and reduces the drop loss of pesticide droplets. In terms of biological activity, for herbivorous lepidopteran pests with an alkaline midgut microenvironment, it showed a highly effective insecticidal effect similar to that of commercial insecticides.

The invention discloses a green and quick preparation method of antibacterial material sodium alginate-ascorbic acid nano-silver. The method includes the following steps that (1) a sodium alginate water solution is prepared; (2) the sodium alginate water solution is heated and magnetically stirred overnight; (3) a silver nitrate solution is dropwise added into the overnight stirred sodium alginatewater solution in accompaniment with vortex treatment; (4) an ascorbic acid solution is dropwise added into the mixture obtained in the step (3) in accompaniment with vortex treatment; (5) ultrasonictreatment is carried out on a mixing system; and (6) the mixing system obtained after ultrasonic treatment is centrifuged, supernate is discarded, washing is carried out, sediment is refrigerated ina refrigerator at the temperature of minus 80 DEG C and subjected to freeze drying through a vacuum freezer dryer at the temperature of minus 40 DEG C, and sodium alginate nano-silver particles are obtained. According to the method, the sodium alginate-ascorbic acid nano-silver material is prepared through ultrasound, quick and green preparation is achieved, and the sodium alginate-ascorbic acid nano-silver material is a fresh-keeping packaging material with high potential and is used for prolonging the practical shelf life of products to be packaged.

The invention relates to a petroleum-degrading bactericide and also relates to a preparation method of the petroleum-degrading bactericide. The preparation method of the petroleum-degrading bactericide comprises the following steps: (1) performing enlage cultivation on such bacteria as caulobacter segnis, candida parapsilosis, brachybacterium phenoliresistens, arthrobacter globiformis and sporidiobolus salmonicolor till the concentration of the bacteria is 10<9>-10<10> cfu / g, and uniformly mixing according to the mass ratio of 3: 2: 2: 1: 1 to obtain a mixed culture; (2) fermenting the mixed culture in a liquid fermentation culture medium for 48-60 h; (3) carrying out centrifugal separation to obtain thick strain cells; (4) uniformly mixing the thick strain cells with a 0.9% NaCl solution and a sea mud leachate; (5) adding nutrient substances, and then preserving at 4 DEG C in a sealed manner. The petroleum-degrading bactericide is high in petroleum degradation rate.