13results about How to "Reduce Potential Toxicity" patented technology

The invention provides a fruit growth regulator and bacteriostatic preservative as well as a preparation method and application thereof, and belongs to the technical field of preservation, pomace is taken as a raw material, and pomace microfibrillated cellulose, pectin and seed oil containing phenolic substances are extracted through organic acid treatment, DES reagent auxiliary mechanical treatment, ethanol water treatment and other treatments; then carrying out hydroformylation modification on nano cellulose, grafting chitosan, and compounding with pectin to obtain dialdehyde microfibrillated cellulose-chitosan-pectin composite particles with pH response performance, and taking the dialdehyde microfibrillated cellulose-chitosan-pectin composite particles as a stabilizer of a Pickering emulsion; the green growth regulator solution is used as a continuous phase, the seed oil mixed Chinese herbal medicine extract is used as a dispersion phase, the controlled-release Pickering emulsion with growth regulation and bacteriostasis effects is prepared, the prepared emulsion is sprayed on berries to form a film layer, the growth process of the berries can be regulated, the fruit yield and quality are improved, and the quality of the berries is improved. And antibacterial substances can be slowly released for preservation when berries are picked and stored.

The present invention relates to a composition comprising certain triglycerides having a low content of cyclopropene-based fatty acid (CPFA) acyl groups and tocopherols, as well as the use of such a composition, especially in cosmetic applications, and a method of treating baobab oil.

The invention provides a milk exosome coated PLGA (poly (lactic-co-glycolic acid)) nano antituberculosis drug system as well as preparation and application thereof. The structure of the system is as follows: anti-tuberculosis drug-milk exosome-coated PLGA-anti-tuberculosis drug. The antituberculous drug is selected from one or a combination of more of aminoquinolones, benzothiazoles, aryl quinoline, nitrobenzamides and benzothiazinone antituberculous drugs. According to the nano antituberculosis drug system, the circulation time of nano particles in blood is prolonged, and the bioavailability of the drug is improved. The cellular uptake efficiency of the nanoparticles is enhanced, and the drug delivery effect is improved. The immunological rejection and the potential toxicity are reduced, and the treatment safety is improved.

The invention discloses an apatinib-immune synergistic nano-drug based on bacterial source vesicles as well as a preparation method and application of the apatinib-immune synergistic nano-drug. The nano-drug is Apatinib-MVs, and the nano-drug takes a membrane vesicle secreted by parabacteroides coumarini as a carrier to entrap an anti-angiogenesis drug apatinib; in-vitro anti-tumor experiment results show that the nano-drug can exert an efficient anti-tumor effect through a dual synergistic mechanism of inhibiting tumor angiogenesis and activating anti-tumor immune response at the same time.

The invention discloses a device and a method for preparing platinum nanoparticles based on plasma jet, and relates to the technical field of preparation of gold nanoparticles. The device comprises a DBD plasma jet device used for generating plasma jet, a power supply system used for providing high frequency and high voltage for a metal rod electrode, a gas inlet system used for providing a gas environment for the device, a quartz reactor used for providing an environment for preparing platinum nanoparticles, and a precursor solution used for generating the platinum nanoparticles, and the precursor solution and the plasma jet are introduced into the quartz reactor through the jet extraction quartz tube to be subjected to a reduction reaction, and platinum nanoparticles are generated. By means of the plasma jet technology, the method has the advantages that the reaction process is rapid and can be completed within a few minutes, the production efficiency is remarkably improved, the method is suitable for large-scale production, and the prepared platinum nanoparticles have good dispersity and stability and can be directly applied to various application fields without additional stabilization treatment.

The invention belongs to the technical field of nano-agents, and discloses a folic acid targeting-based liposome nano-particle as well as a preparation method and application of the folic acid targeting-based liposome nano-particle. The preparation method comprises the following steps: dissolving phospholipid, cholesterol, polyethylene glycol, folic acid modified polyethylene glycol and a fluorescent dye in a solvent, and carrying out rotary evaporation to form a uniform film; preparing nano ferroferric oxide into a hydrated solution; adding the hydration liquid into the thin film to carry out hydration treatment until no solid substance exists; and then adding microRNA (Ribonucleic Acid) to carry out RNA loading, so as to prepare the lipidosome nano particles. The liposome nanoparticles provided by the invention can integrate a plurality of functional substances into the same nano-carrier to realize the synergistic effect of multi-modal diagnosis and treatment, so that an integrated cancer diagnosis and treatment scheme is realized, the treatment effect is improved, and side effects are reduced.

This invention provides a cerium oxide-containing composite sunscreen raw material and its preparation method, belonging to the field of materials technology. The invention involves synthesizing a cerium oxide-containing composite oxide via a co-precipitation method, then using gelatin-chitosan as a wall material to encapsulate the composite oxide. A stable coating layer is formed through cross-linking and curing, reducing the photocatalytic activity of cerium oxide and improving dispersion stability. This invention significantly reduces the potential toxicity of traditional chemical sunscreens to the human body, while expanding the photoprotection range to the visible light region, achieving "full-spectrum" (200-800 nm) protection.

The application discloses application of methylated gossypol in preparation of a coronavirus inhibitor. The application provides application of at least one of a compound as shown in a formula I, a solvate of the compound, a pharmaceutically acceptable salt of the compound, a solvate of the pharmaceutically acceptable salt of the compound in preparation of the coronavirus inhibitor. The compound provided by the application has the advantages of clear target, high safety, significantly improved inhibitory activity, potential for wide application and potential therapeutic effect on diseases caused by the novel coronavirus.

The invention discloses a method for preventing and treating citrus canker pathogens by using an antibacterial peptide, and relates to the technical field of biology, the embodiment of the invention provides a method for preventing and treating citrus canker pathogens by using an antibacterial peptide, and the method comprises the following steps: infectively cloning CLBV which does not influence the physiological status of citrus into a biological expression vector of the antibacterial peptide; the influence possibly caused by a conventional transgenosis means on the physiological phenotype of the citrus can be effectively overcome; the antibacterial peptide is fused with the exocrine signal peptide, so that the expressed antibacterial peptide is promoted to be secreted out of cells, and the potential toxicity of the antibacterial peptide to citrus cells can be reduced; by utilizing the characteristics that the CLBV can systematically infect the citrus and stably exists for a long time, multiple inoculation analysis on a treatment group can be realized, and the preciseness of an evaluation result of the control effect of the antibacterial peptide is ensured.

The invention discloses a method for improving electrophysiological activity of myocardial cells based on molecular thermal vibration. The method comprises the following steps: culturing purified animal myocardial cells on a cell electrophysiological sensor so as to establish a chronic arrhythmia model of an in-vitro myocardial cell type, and constructing a photo-thermal sensing regulation and control platform for improving the electrophysiological activity of the myocardial cells on the basis of the chronic arrhythmia model. After the small organic molecules with the photothermal effect are added in a bionic drug mode, light energy can be quickly converted into heat energy under irradiation of near-infrared light, so that the temperature of a myocardial cell culture system is increased, myocardial cells are stimulated to react, and then the electrophysiological activity of the myocardial cells is improved. The myocardial cell electrophysiological signals before irradiation, during irradiation and after irradiation are recorded, and the change of the characteristic parameters of the electrophysiological signals is analyzed, so that the regulation and control effect is evaluated; and a brand new research thought is provided for bionic medicines and precise biomedical treatment.

The invention relates to a biochar compound and a method for reducing the influence of soil film residue on crops, the biochar compound comprises the following components by weight: 10-15% of bentonite, 3-5% of polyacrylamide, 0.1-0.2% of EPS, 3-5% of a yeast extract, 0.5-1% of a pine extract, 0.1-0.3% of a mint extract, 0.01-0.03% of iron oxide, 0.01-0.03% of molybdenum disulfide, and the balance of water. And the balance of charcoal. By adopting the combination of the porous material, the thallus enrichment material, the residual film decomposition aid and the slow-release material, on one hand, the permeability of soil containing the residual film can be effectively improved, and the influence of the residual film on crop growth is reduced; on the other hand, degradation of the residual film can be effectively promoted, and then the content of the residual film in the soil is reduced.

This invention belongs to the field of organic chemistry, specifically providing a class of compounds that can be selectively activated by hypochlorous acid to release hydroxyl groups, along with their preparation methods and applications. These compounds, triggered by HOCl, can efficiently release target molecules containing hydroxyl groups, enabling corresponding treatment, intervention, or functional execution. Simultaneously, these compounds can generate detectable signals such as fluorescence while releasing the charge, allowing for in-situ / real-time monitoring of HOCl levels and the release process in lesion areas, providing a basis for disease assessment and efficacy tracking. These compounds remain relatively inert in normal tissues or when HOCl is at physiological levels, reducing disturbance to HOCl in normal areas and helping to maintain overall HOCl homeostasis and basic immune defense functions. This invention develops a class of compounds that can rapidly respond to hypochlorous acid, release hydroxyl-containing drugs, and monitor disease treatment.

The invention discloses a method for preparing bio-oil through co-pyrolysis of waste oil and waste wood treated by chromized copper arsenate, and relates to the technical field of biomass thermal conversion, and the method comprises the following steps: crushing and screening the waste wood treated by chromized copper arsenate to obtain biomass powder; the method comprises the following steps: adding waste oil into biomass powder, uniformly mixing, carrying out rapid pyrolysis and heat preservation in an inert atmosphere, and obtaining a pyrolysis product after heat preservation is finished; and condensing and separating the pyrolysis product to obtain high-quality bio-oil and charcoal. In the co-pyrolysis process of the waste oil and the waste wood treated by the chromized copper arsenate, the waste oil and the waste wood treated by the chromized copper arsenate are jointly pyrolyzed into high-quality bio-oil, meanwhile, highly toxic polycyclic aromatic hydrocarbon in the bio-oil is controlled within a reasonable range, and residual heavy metals such as Cu, Cr and As in the waste wood treated by the chromized copper arsenate are fixed in the biochar, so that the waste wood treated by the chromized copper arsenate and the waste wood treated by the chromized copper arsenate are fully utilized. Meanwhile, the environmental risk level of the biochar is reduced to be clean.