5results about How to "Reduce Potential Toxicity" patented technology

The present invention relates to a composition comprising certain triglycerides having a low content of cyclopropene-based fatty acid (CPFA) acyl groups and tocopherols, as well as the use of such a composition, especially in cosmetic applications, and a method of treating baobab oil.

The invention discloses an apatinib-immune synergistic nano-drug based on bacterial source vesicles as well as a preparation method and application of the apatinib-immune synergistic nano-drug. The nano-drug is Apatinib-MVs, and the nano-drug takes a membrane vesicle secreted by parabacteroides coumarini as a carrier to entrap an anti-angiogenesis drug apatinib; in-vitro anti-tumor experiment results show that the nano-drug can exert an efficient anti-tumor effect through a dual synergistic mechanism of inhibiting tumor angiogenesis and activating anti-tumor immune response at the same time.

This invention provides a cerium oxide-containing composite sunscreen raw material and its preparation method, belonging to the field of materials technology. The invention involves synthesizing a cerium oxide-containing composite oxide via a co-precipitation method, then using gelatin-chitosan as a wall material to encapsulate the composite oxide. A stable coating layer is formed through cross-linking and curing, reducing the photocatalytic activity of cerium oxide and improving dispersion stability. This invention significantly reduces the potential toxicity of traditional chemical sunscreens to the human body, while expanding the photoprotection range to the visible light region, achieving "full-spectrum" (200-800 nm) protection.

The application discloses application of methylated gossypol in preparation of a coronavirus inhibitor. The application provides application of at least one of a compound as shown in a formula I, a solvate of the compound, a pharmaceutically acceptable salt of the compound, a solvate of the pharmaceutically acceptable salt of the compound in preparation of the coronavirus inhibitor. The compound provided by the application has the advantages of clear target, high safety, significantly improved inhibitory activity, potential for wide application and potential therapeutic effect on diseases caused by the novel coronavirus.

This invention belongs to the field of organic chemistry, specifically providing a class of compounds that can be selectively activated by hypochlorous acid to release hydroxyl groups, along with their preparation methods and applications. These compounds, triggered by HOCl, can efficiently release target molecules containing hydroxyl groups, enabling corresponding treatment, intervention, or functional execution. Simultaneously, these compounds can generate detectable signals such as fluorescence while releasing the charge, allowing for in-situ / real-time monitoring of HOCl levels and the release process in lesion areas, providing a basis for disease assessment and efficacy tracking. These compounds remain relatively inert in normal tissues or when HOCl is at physiological levels, reducing disturbance to HOCl in normal areas and helping to maintain overall HOCl homeostasis and basic immune defense functions. This invention develops a class of compounds that can rapidly respond to hypochlorous acid, release hydroxyl-containing drugs, and monitor disease treatment.