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46results about How to "Reduce Potential Toxicity" patented technology
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3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof
InactiveUS20150291654A1Eliminate potentialInhibit metabolismSenses disorderNervous disorderInsomniaBrain traumas
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I) and (III): where R1, R2, R3, R3′, R4, R6a, R6a, R11a, and R11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (TBI), stress, and epilepsy.
Owner:SAGE THERAPEUTICS
Residual solvent extraction method and microparticles produced thereby
InactiveUS20060099271A1Decrease in levelReduce residue levelsOrganic active ingredientsPowder deliveryMicroparticleHeptane
Owner:ALKERMES PHARMA IRELAND LTD
Nutritional supplement with functions of oxidation resistance and fatigue resistance
ActiveCN102150861AImprove antioxidant capacityImprove fatigue resistanceFood preparationPotential toxicityGrape seed
The invention relates to a nutritional supplement with functions of oxidation resistance and fatigue resistance, which is prepared from active ingredients and auxiliary materials such as multiple vitamins, mineral substances, siberian ginseng extracts, astragalus mongholicus extracts, medlar extracts, grape seed extracts and the like. The active ingredients in the supplement have a special proportion; the nutritional supplement can achieve the same effects of oxidation resistance and fatigue resistance by using a dose of traditional Chinese medical extracts smaller than the conventional dose;and the nutritional supplement has the characteristics of low potential toxicity, low production cost, obvious treatment effect and low price, thereby being suitable for long-time use.
Owner:辽宁亿邦制药有限公司
19-nor c3, 3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
ActiveUS20160083417A1Eliminate potential for oxidationInhibit metabolismOrganic active ingredientsNervous disorderDiseaseSubstance abuser
Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein, , R1, R2, R3a, R3b, R4a, and R4b are as defined herein, and A is a carbon bound substituted or unsubstituted 5- to 6-membered heteroaryl ring as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and / or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and / or withdrawal syndromes, and tinnitus.
Owner:SAGE THERAPEUTICS
Petroleum-degrading bactericide and preparation method thereof
ActiveCN105483058APromote regrowthThe preparation process is simple and economicalFungiBacteriaNutrientPetroleum
The invention relates to a petroleum-degrading bactericide and also relates to a preparation method of the petroleum-degrading bactericide. The preparation method of the petroleum-degrading bactericide comprises the following steps: (1) performing enlage cultivation on such bacteria as caulobacter segnis, candida parapsilosis, brachybacterium phenoliresistens, arthrobacter globiformis and sporidiobolus salmonicolor till the concentration of the bacteria is 10<9>-10<10> cfu / g, and uniformly mixing according to the mass ratio of 3: 2: 2: 1: 1 to obtain a mixed culture; (2) fermenting the mixed culture in a liquid fermentation culture medium for 48-60 h; (3) carrying out centrifugal separation to obtain thick strain cells; (4) uniformly mixing the thick strain cells with a 0.9% NaCl solution and a sea mud leachate; (5) adding nutrient substances, and then preserving at 4 DEG C in a sealed manner. The petroleum-degrading bactericide is high in petroleum degradation rate.
Owner:NORTH CHINA SEA ENVIRONMENTAL MONITORING CENT OF STATE OCEANIC ADMINISTATION
Extraction method of longan seed polyphenol
InactiveCN102961486AReduce oxidase activityReduce pollutionCosmetic preparationsToilet preparationsEconomic benefitsPolyphenol
The invention relates to an extraction method of longan seed polyphenol, relating to a processing method of a longan. The extraction method of the longan seed polyphenol can enhance the economic benefit of a longan industry and increase the income of fruit growers. The extraction method of the longan seed polyphenol comprises the following steps of: drying cleaned longan seeds; smashing raw material longan seeds to obtain longan seed powder; adding a sodium phosphate buffer solution to the longan seed powder to obtain a leach solution; pouring out the leach solution, filtering, removing leaching residues, and recovering immersion liquid; concentrating obtained filter liquor to obtain a concentrated solution; adding hydrochloric acid to the concentrated solution, stirring, and then standing for precipitation to obtain a precipitation solution; centrifugalizing the precipitation solution, removing a supernatant, washing precipitates by using the hydrochloric acid, and then drying to obtain fine longan seed polyphenol powder.
Owner:XIAMEN UNIV
Method for producing metal nanoparticles
InactiveCN102978241AGood size controlControllable distributionMicroorganism based processesFermentationPlatinumColloidal nanoparticles
This invention provides a method for producing a composition comprising colloidal nanoparticles of metals including silver, gold, zinc, mercury, copper, palladium, platinum, or bismuth, by contacting a metal or metal compound with bacteria. An embodiment of the method comprises a step of incubating probiotic bacteria with an aqueous solution comprising at least 4 mM of a silver or gold salt. A resulting nanosilver-containing composition is useful as a highly efficient antimicrobial agent, for instance when impregnated onto a carrier, or an algicide agent or a herbicide agent.
Owner:JANSSEN PHARMA NV
Nanoparticles for use for treating a neuronal disorder
ActiveUS20190351231A1Total current dropReduce known potential toxicityNervous disorderElectrotherapyNervous systemSemiconductor materials
The present invention relates to the medical field, in particular to the treatment of neurological disorders. More specifically the present invention relates to a nanoparticle or nanoparticles' aggregate for use in prevention or treatment of a neurological disease or at least one symptom thereof in a subject when the nanoparticle or nanoparticles' aggregate is exposed to an electric field, wherein the nanoparticle's or nanoparticles' aggregate's material is selected from a conductor material, a semiconductor material, an insulator material with a dielectric constant εijk equal to or above 200, and an insulator material with a dielectric constant εijk equal to or below 100. It further relates to compositions and kits comprising such nanoparticles and / or nanoparticles' aggregates as well as to uses thereof.
Owner:NANOBIOTIX SA
Hydrobromide of benzodiazepine derivative and multiple crystal forms thereof, and preparation method for multiple crystal forms
Owner:CHENGDU BRILLIANT PHARMA CO LTD
Bismuth alginate and preparation method and application thereof
ActiveCN102558383APromote wound healingGood development valueAntibacterial agentsOrganic active ingredientsPotential toxicityEthanol precipitation
Owner:INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Neuroactive steroids, compositions, and uses thereof
PendingUS20180179247A1Eliminate potential for oxidationInhibit metabolismOrganic active ingredientsNervous disorderWithdrawal syndromeSubstance abuse disorder
Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and / or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and / or withdrawal syndromes, and tinnitus.
Owner:SAGE THERAPEUTICS
Etoposide long-circulating emulsion and preparation method thereof
InactiveCN102247320AReduces vascular irritation and potential toxicityAvoid drug degradationOrganic active ingredientsEmulsion deliveryChemistryEmulsion
The invention belongs to the field of medicinal preparations, and relates to an etoposide long-circulating emulsion for injection, and a preparation method thereof. The etoposide long-circulating emulsion comprises etoposide, fluid oil, emulsifiers, polyethylene glycol (PEG) modified esters and the like, and has the characteristics of high entrapment rate, good stability and low toxicity. The etoposide long-circulating emulsion improves the solubility and the stability of etoposide, reduces irritation effects of etoposide on blood vessels, prolongs cycle time of etoposide in blood, and improves distribution of etoposide in vivo thus improves drug curative effects. The preparation method of the etoposide long-circulating emulsion solves the carrying problems of drugs with poor water-solubility and fat-solubility and realizes stable preservation and no drug precipitation. The preparation method has the characteristics of simple process, low cost and good applicability for industrializedproduction.
Owner:TIANJIN INSTITUTE OF PHARMA RESEARCH
Method of preparing humus and recovering heavy-metal-polluted bottom mud with humus
ActiveCN108341564ARealize resourcesLow costSludge treatmentWater contaminantsSesamum orientaleGreen waste
The invention discloses a method of preparing humus and recovering heavy-metal-polluted bottom mud with the humus. Green waste, wood dust, bean pulp, humus soil and / or grape residues are proportionedon the basis of the compost raw material mass proportion of (4.5-5.5):(1.8-2.2):1:(1.8-2.2):(1.8-2.2), wherein the green waste is one or more of peanut straws, corn straws, sesame straws and maple leaves; a C / N mass ratio and moisture content are adjusted, white-rot fungi and trichoderma viride are inoculated, and aerobic composting is conducted; after composting, the humus in the mixture is extracted. According to the method of preparing humus and recovering the heavy-metal-polluted bottom mud with the humus, the polluted bottom mud is leached with a humus solution to remove heavy metal and complete a recovery process. The humus in an extractable state generated through green waste composting serves as a leaching agent, which makes the method more efficient and environmentally friendly, no new heavy metal pollution can be generated, the cost is low, and humus generation through composting achieves waste recycling better.
Owner:HUNAN UNIV
Sesamol Derivatives as Novel Inhibitors of Arachidonic Acid Formation
InactiveUS20090012157A1Low toxicityReduce Potential ToxicityBiocideNervous disorderDepressantMedicinal chemistry
The invention relates to a novel class of inhibitor of arachidonic acid useful for treating inflammatory conditions. Specifically, the invention relates to hydrophobic and hydrophilic derivatives of sesamol that confer lower toxicity and increased circulatory lifetimes than pure sesamol.
Owner:SEARS BARRY D
Nano composite material based on enzyme degradation enhanced photo-thermal removal of bacterial biofilms, and preparation method and application of nano composite material
ActiveCN110974961ALess prone to drug resistanceAchieve controlled releaseAntibacterial agentsPowder deliveryAmylasePolyethylene glycol
The invention discloses a nano composite material based on enzyme degradation enhanced photo-thermal removal of bacterial biofilms, and a preparation method and application of the nano composite material. The nano composite material is a MnO2 nano sheet (namely MnO2-amylase-PEG-ICG NSs, MAPI for short) modified by amylase, polyethylene glycol (PEG) and indocyanine green (ICG). The material can degrade extracellular polymers (EPS) of a biofilm through the amylases, damage the structure of the biofilm, and further enhance the photo-thermal sterilization effect of the ICG. The MAPI provided by the invention has the advantages of good stability, excellent bacteria killing effect in a biofilm and small cytotoxicity, and can meet basic conditions of biological medicine application.
Owner:NANJING UNIV OF POSTS & TELECOMM
DNA molecules stabilized for propagation in bacterial cells that encode cystic fibrosis transmembrane conductance regulator
ActiveUS7118911B1Reduce potential toxicityStably propagateSugar derivativesGenetic material ingredientsMutantAntibody
Disclosed are full length isolated DNAs encoding cystic fibrosis transmembrane conductance regulator (CFTR) protein and a variety of mutants thereof. Also disclosed are antibodies specific for various CFTR domains and methods for their production. Expression of CFTR from cells transformed with these CFTR genes or cDNAs demonstrate surprising CFTR intracellular distributions and results thereby providing for new diagnostic and therapeutic procedures.
Owner:GENZYME CORP
Dexibuprofen guaiacol ester and preparation method thereof
InactiveCN101456814AAvoid damageAvoid gastrointestinal reactionsOrganic active ingredientsPreparation from carboxylic acid halidesGuaiacolBULK ACTIVE INGREDIENT
The invention relates to a novel optical isomer compound of a formula (1), in particular to a dextroisomer of ibuprofen guaiacol ester. The invention also discloses a method for preparing the compound, a drug composition taking the compound as an active ingredient and application of the compound and the drug composition to the preparation of drugs of diminishing inflammation, effectively alleviating various pain or having effects of relieving fever of adults and / or children.
Owner:HUNAN JIUDIAN PHARMA
Use of rhamnose and derivatives thereof as antifungal agents
ActiveUS20200222445A1Good antifungal activityImprove securityOrganic active ingredientsAntimycoticsAntifungalPharmaceutical drug
It relates to a rhamnose or a rhamnose-rich polysaccharide for use in the treatment and / or prevention of fungal infections in human beings. It also relates to a combination of rhamnose or a rhamnose-rich polysaccharide and a further antifungal agent for use in the treatment and / or prevention of fungal infections in human beings. It also relates to pharmaceutical or cosmetic composition comprising an effective amount of rhamnose or a rhamnose-rich polysaccharide for use in the treatment and / or prevention of fungal infections in human beings.
Owner:ISDIN
Drug delivery system of small interfering RNA drug and preparation
InactiveCN102727907BHigh encapsulation efficiencyHigh drug loadingMicroencapsulation basedGenetic material ingredientsPolyethylene glycolBULK ACTIVE INGREDIENT
Owner:SUZHOU RIBO LIFE SCIENCE CO LTD
Pesticide Composition Having Improved Rainfastness
InactiveUS20140309113A1Improve rain resistanceImprove abilitiesBiocidePhosphorous compound active ingredientsToxicologyPolyethylenimine
A pesticide composition includes an active component and polyethyleneimine having a weight average molecular weight of at least about 750,000 g / mol and has improved rainfastness. The polyethyleneimine of this invention has decreased mobility in water as compared to related lower molecular weight analogs. The pesticide composition is formed using a method that includes the steps of providing the active component, providing the polyethyleneimine, and combining the active component and the polyethyleneimine to form the pesticide composition.
Owner:BASF AG
Immunogenic composition
ActiveUS9855325B2Quantity minimizationReduce Potential ToxicityAntibacterial agentsSsRNA viruses positive-senseMedicineCarrier protein
The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype Ia conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype Ib conjugated to a carrier protein; c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein; d) a conjugate that is a capsular saccharide from GBS serotype II conjugated to a carrier protein; and e) a conjugate that is a capsular saccharide from GBS serotype V conjugated to a carrier protein.
Owner:GLAXOSMITHKLINE BIOLOGICALS SA
Protein or polypeptide drug-loaded tissue adhesive film and preparation method thereof
InactiveCN105902522AGood tissue adhesionGood biocompatibilityPeptide/protein ingredientsAntibody ingredientsBiocompatibility TestingPolymer chemistry
Owner:苏州博创同康医药科技有限公司
Preposed cavitation type marihuana fat-soluble active matter soluble microneedle as well as preparation method and application thereof
PendingCN114225033AReduce resistanceIncreased transdermal penetration coefficientHeavy metal active ingredientsHydroxy compound active ingredientsCannabisPharmaceutical drug
The invention relates to a preposed cavitation type hemp fat-soluble active matter soluble microneedle, which comprises a backing layer and a microneedle array fixed on the backing layer, and one of active metal particles, bicarbonate, bicarbonate, cerium dioxide particles or cerium-zirconium composite oxide particles is embedded in the tip part of the microneedle; and the needle body is filled with a soluble microneedle matrix material containing a cannabis fat-soluble active matter solid dispersion. According to the preposed cavitation type cannabis sativa active ingredient microneedle disclosed by the invention, by utilizing preposed bubbles, the delivery resistance of an embedded medicine to a tumor deep layer is greatly reduced, and the transdermal permeability coefficient is greatly improved; generated hydrogen / oxygen / carbon dioxide and the like can remarkably improve the tumor immunosuppression microenvironment and cooperate with other embedded anti-tumor drugs to improve the treatment efficiency; and the required administration dosage is greatly reduced, so that the potential toxicity is reduced, and the comprehensive treatment efficiency on various superficial skin tumors is obviously improved.
Owner:中纳科(南京)生物科技有限公司
Color developing system for responding to rot smell of meat through color change, and preparation method and application thereof
ActiveCN109884045AAvoid harmReduce Potential ToxicityMaterial nanotechnologyMaterial analysis by observing effect on chemical indicatorPotential toxicityNon toxicity
The invention discloses a nano-silver color developing system for responding to a rot smell of meat through color change, and a preparation method and an application thereof, and belongs to the fieldof food monitoring. According to the color developing system, an Arabic gum powder solution is added into a silver nitrate solution and the solutions are stirred uniformly; then a reaction is carriedout under a high-temperature and high-pressure condition; and after the reaction is ended, filtering is carried out to obtain the Arabic gum powder-nano-silver color developing system. Compared with atraditional nano-silver preparation method, the preparation method has the following advantages: the preparation method of the Arabic gum powder-nano-silver color developing system which follows "green chemistry" shows the advantages of safety, non-toxicity, environmental friendliness and the like, and greatly reduces the toxic effect generated by the traditional preparation method. By selectinga food-grade safe medium, the potential toxicity generated for the environment and organisms is reduced. Meanwhile, certain harm to the environment caused by toxic substances generated in a synthesisprocess is avoided.
Owner:NANJING AGRICULTURAL UNIVERSITY
Extraction method of longan seed polyphenol
InactiveCN102961486BReduce oxidase activityReduce pollutionCosmetic preparationsToilet preparationsPregnant leach solutionEconomic benefits
The invention relates to an extraction method of longan seed polyphenol, relating to a processing method of a longan. The extraction method of the longan seed polyphenol can enhance the economic benefit of a longan industry and increase the income of fruit growers. The extraction method of the longan seed polyphenol comprises the following steps of: drying cleaned longan seeds; smashing raw material longan seeds to obtain longan seed powder; adding a sodium phosphate buffer solution to the longan seed powder to obtain a leach solution; pouring out the leach solution, filtering, removing leaching residues, and recovering immersion liquid; concentrating obtained filter liquor to obtain a concentrated solution; adding hydrochloric acid to the concentrated solution, stirring, and then standing for precipitation to obtain a precipitation solution; centrifugalizing the precipitation solution, removing a supernatant, washing precipitates by using the hydrochloric acid, and then drying to obtain fine longan seed polyphenol powder.
Owner:XIAMEN UNIV
Dihydroisoquinoline compound
ActiveCN111410653AImprove bioavailabilityReduce Potential ToxicityOrganic active ingredientsOrganic chemistryIsoquinolineChemical compound
The invention provides a dihydroisoquinoline compound or a pharmaceutically acceptable salt, ester, isomer, solvate, hydrate, prodrug or isotope marker thereof. The compound has a structure shown as ageneral formula I. The compound has extremely strong activity of inhibiting hepatitis B surface antigen, also has extremely strong activity of inhibiting hepatitis B DNA, has relatively high bioavailability, can play a drug effect at a relatively low dosage, and reduces the potential toxicity of the compound.
Owner:SUZHOU ARK BIOPHARM CO LTD
Preparation and application of polydopamine-encapsulated mesoporous silica nano-drug delivery system
ActiveCN113519510BNot easy to slipReduce lossesBiocideAnimal repellantsNanoparticlePhotothermal conversion
The invention discloses the preparation and application of a polydopamine-encapsulated mesoporous silica nanometer drug-carrying system, which belongs to the application development of nanotechnology in the agricultural field. The nano-drug loading system uses mesoporous silica nanoparticles as the carrier of the pesticide, and is formed by encapsulating polydopamine after adsorbing the pesticide. The nano-drug loading system described in the present invention has pH responsiveness and can promote the release of loaded pesticide molecules under alkaline conditions. The nano-drug-loading system has good photothermal conversion ability. Under the irradiation of near-infrared light, the temperature of the system is increased, which is beneficial to the release of pesticide components. Through the encapsulation of polydopamine, the nano-drug-loading system has good leaf adhesion properties and reduces the drop loss of pesticide droplets. In terms of biological activity, for herbivorous lepidopteran pests with an alkaline midgut microenvironment, it showed a highly effective insecticidal effect similar to that of commercial insecticides.
Owner:NANJING UNIV +1
A green rapid preparation method of antibacterial material sodium alginate-ascorbic acid nano silver
ActiveCN107716943BPotentially Harmful DisadvantageReduce Potential ToxicityBiocideNanotechnologyFreeze-dryingSilver particles
The invention discloses a green and quick preparation method of antibacterial material sodium alginate-ascorbic acid nano-silver. The method includes the following steps that (1) a sodium alginate water solution is prepared; (2) the sodium alginate water solution is heated and magnetically stirred overnight; (3) a silver nitrate solution is dropwise added into the overnight stirred sodium alginatewater solution in accompaniment with vortex treatment; (4) an ascorbic acid solution is dropwise added into the mixture obtained in the step (3) in accompaniment with vortex treatment; (5) ultrasonictreatment is carried out on a mixing system; and (6) the mixing system obtained after ultrasonic treatment is centrifuged, supernate is discarded, washing is carried out, sediment is refrigerated ina refrigerator at the temperature of minus 80 DEG C and subjected to freeze drying through a vacuum freezer dryer at the temperature of minus 40 DEG C, and sodium alginate nano-silver particles are obtained. According to the method, the sodium alginate-ascorbic acid nano-silver material is prepared through ultrasound, quick and green preparation is achieved, and the sodium alginate-ascorbic acid nano-silver material is a fresh-keeping packaging material with high potential and is used for prolonging the practical shelf life of products to be packaged.
Owner:ZHEJIANG UNIV
Polysaccharide medicine loading tissue adhesion film and preparing method thereof
InactiveCN106038517AProcess stabilityGood tissue adhesionPeptide/protein ingredientsGenetic material ingredientsPolysaccharidePhysical performance
The invention relates to the field of biological medicine, in particular to a polysaccharide medicine loading tissue adhesion film and a preparing method thereof. The polysaccharide medicine loading tissue adhesion film comprises cationic layers and anionic layers, wherein the cationic layers and the anionic layers are stacked alternately. At least one layer in the cationic layers and the anionic layers is a medicine layer, or at least one layer in the cationic layers and the anionic layers contains medicine with charges, and polysaccharide medicine serves as the medicine. The polysaccharide medicine loading tissue adhesion film has good tissue adhesion and high biological compatibility, degradation absorbability and stability, and the physical performance and the chemical performance of the polysaccharide medicine loading tissue adhesion film can be adjusted by adjusting the constitution of materials.
Owner:苏州博创同康医药科技有限公司
A kind of petroleum degrading bacterial agent and preparation method thereof
ActiveCN105483058BImprove degradation rateGood synergyFungiBacteriaArthrobacter globiformisCaulobacter segnis
Owner:NORTH CHINA SEA ENVIRONMENTAL MONITORING CENT OF STATE OCEANIC ADMINISTATION
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