Topical gel composition for treatment of actinic keratosis and pharmaceutical use thereof

一种光化性角化病、凝胶组合物的技术，应用在药物组合、过敏性疾病、非有效成分的医用配制品等方向，达到高药理利用度、快速吸收或干燥的效果

Inactive Publication Date: 2015-08-12
ALMIRALL HERMAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been found that topical administration of compositions comprising these levels of 5'-fluorouracil elicits a number of side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0042] A product with the following composition (wt%) was prepared:

[0043] 5'-Fluorouracil

example 2

[0045] A product with the following composition (wt%) was prepared:

[0046] 5'-Fluorouracil

example 3

[0048] A product with the following composition (wt%) was prepared:

[0049] 5'-Fluorouracil

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PUM

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Abstract

The invention relates to a topical gel composition comprising (a) an active agent for treatment of actinic keratosis, (b) a keratolytically active agent, (c) a gel former and (d) an organic solvent for use in the treatment of actinic keratosis.

Description

[0001] This application is a divisional application of an invention patent application with an application date of June 29, 2009, an application number of "200980126663.5", and an invention title of "a topical composition for treating actinic keratosis". technical field [0002] The present invention relates to a topical composition useful as a medicine for the treatment of actinic keratoses. Background technique [0003] Actinic keratosis is a carcinoma in situ of the epidermis. It is associated with the proliferation of transformed keratinocytes confined to the epidermis, characterized by, inter alia, a high mutation rate of the tumor suppressor gene p53 and the telomerase gene. It is further associated with characteristic chromosomal aberrations that also commonly occur in invasive cutaneous squamous cell carcinoma. In about 10% of all patients with actinic keratoses, especially in about 30% of patients who are also immunosuppressed, the condition progresses to squamous ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K45/00A61K31/513A61K31/60A61K31/192A61P17/12
CPCA61K9/06A61K31/196A61K45/06A61K31/513A61K9/0014A61K31/60A61K47/32A61P17/00A61P17/02A61P17/12A61P35/00A61P37/02A61P43/00A61K2300/00
Inventor M·迈泽尔C·马蒂斯K·图德勒C·威勒斯H·马尔维茨
Owner ALMIRALL HERMAL
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