Injectable long-acting local anesthetic semi-solid formulations and its compostions

A semi-solid, active ingredient technology, applied in the field of injectable long-acting local anesthetic semi-solid preparations and their components, can solve the problems of unsatisfactory pain relief, expensive, cumbersome and the like

Active Publication Date: 2015-12-02
HUZHOU HUI ZHONG JI SHI BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] While the above systems are useful, their manufacturing processes are complex, cumbersome and expensive
In addition, these products have a large amount of drug release (also called "burst release") i

Method used

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  • Injectable long-acting local anesthetic semi-solid formulations and its compostions
  • Injectable long-acting local anesthetic semi-solid formulations and its compostions
  • Injectable long-acting local anesthetic semi-solid formulations and its compostions

Examples

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Embodiment

[0098] Example description

[0099] 1. Preparation of pharmaceutical composition

[0100] Semi-solid local anesthetic pharmaceutical compositions are prepared by adding the local anesthetic, semi-solid lipid, and modified excipients to a glass vessel and heating to approximately 60°C to 95°C, depending on the local anesthetic and carrier composition used The properties of semi-solid lipids and modified excipients are completely melted into a solution, and the active drug is completely dissolved in the drug release carrier to form a transparent solution by constant stirring. After a homogeneous and uniform pharmaceutical composition has been achieved, the semisolid formulation of the local anesthetic may be allowed to cool naturally to ambient temperature.

[0101] A.60wt% S378: 40wt% Tetracaine / Lidocaine (1:2)

[0102] After heating to 60°C, all the compositions were completely melted, and after the two local anesthetics were dissolved, all the compositions formed a transpar...

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Abstract

A semi-solid controlled release composition containing biocompatible and bioerodible semi-solid lipid matrix incorporating local anesthetics agents to form a semi-solid solution arsd the methods of manufacturing are disclosed.

Description

[0001] Related patent application reference [0002] This patent is a continuation-in-part of U.S. Patent Application Serial No. 61 / 771,011, filed February 28, 2013, which is hereby incorporated by reference, requiring U.S. Patent Application Serial No. 61 / 771, filed February 28, 2013 771,011, which is hereby incorporated by reference. technical field [0003] The invention provides a semi-solid lipid matrix as a drug carrier and a semi-solid component for drug controlled release, including a semi-solid lipid carrier and a local anesthetic. The pharmaceutical composition may be in the form of an injectable or topically administered local anesthetic for the controlled release of local anesthetic for the treatment of postoperative pain. Background of the invention [0004] Intravenous administration of analgesic pump (PCA) or oral morphine is currently the main method for the treatment of postoperative pain. These drugs, while highly effective, have significant side effects,...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/14
CPCA61K9/0019A61K47/14A61K31/445A61P23/02
Inventor 沈惠荣甘娜
Owner HUZHOU HUI ZHONG JI SHI BIOTECHNOLOGY CO LTD
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