Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Injectable long-acting local anesthetic semi-solid formulations and its compostions

A semi-solid, active ingredient technology, applied in the field of injectable long-acting local anesthetic semi-solid preparations and their components, can solve the problems of unsatisfactory pain relief, expensive, cumbersome and the like

Active Publication Date: 2015-12-02
HUZHOU HUI ZHONG JI SHI BIOTECHNOLOGY CO LTD
View PDF14 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] While the above systems are useful, their manufacturing processes are complex, cumbersome and expensive
In addition, these products have a large amount of drug release (also called "burst release") in the early stage after injection, and the kinetics of drug release are not good, and the repeatability is poor, so the analgesic effect in animal experiments and human experiments is not ideal. Unreliable

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Injectable long-acting local anesthetic semi-solid formulations and its compostions
  • Injectable long-acting local anesthetic semi-solid formulations and its compostions
  • Injectable long-acting local anesthetic semi-solid formulations and its compostions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0098] Example description

[0099] 1. Preparation of pharmaceutical composition

[0100] Semi-solid local anesthetic pharmaceutical compositions are prepared by adding the local anesthetic, semi-solid lipid, and modified excipients to a glass vessel and heating to approximately 60°C to 95°C, depending on the local anesthetic and carrier composition used The properties of semi-solid lipids and modified excipients are completely melted into a solution, and the active drug is completely dissolved in the drug release carrier to form a transparent solution by constant stirring. After a homogeneous and uniform pharmaceutical composition has been achieved, the semisolid formulation of the local anesthetic may be allowed to cool naturally to ambient temperature.

[0101] A.60wt% S378: 40wt% Tetracaine / Lidocaine (1:2)

[0102] After heating to 60°C, all the compositions were completely melted, and after the two local anesthetics were dissolved, all the compositions formed a transpar...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Viscosityaaaaaaaaaa
Viscosity valueaaaaaaaaaa
Viscosityaaaaaaaaaa
Login to View More

Abstract

A semi-solid controlled release composition containing biocompatible and bioerodible semi-solid lipid matrix incorporating local anesthetics agents to form a semi-solid solution arsd the methods of manufacturing are disclosed.

Description

[0001] Related patent application reference [0002] This patent is a continuation-in-part of U.S. Patent Application Serial No. 61 / 771,011, filed February 28, 2013, which is hereby incorporated by reference, requiring U.S. Patent Application Serial No. 61 / 771, filed February 28, 2013 771,011, which is hereby incorporated by reference. technical field [0003] The invention provides a semi-solid lipid matrix as a drug carrier and a semi-solid component for drug controlled release, including a semi-solid lipid carrier and a local anesthetic. The pharmaceutical composition may be in the form of an injectable or topically administered local anesthetic for the controlled release of local anesthetic for the treatment of postoperative pain. Background of the invention [0004] Intravenous administration of analgesic pump (PCA) or oral morphine is currently the main method for the treatment of postoperative pain. These drugs, while highly effective, have significant side effects,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/00A61K47/14
CPCA61K9/0019A61K47/14A61K31/445A61P23/02
Inventor 沈惠荣甘娜
Owner HUZHOU HUI ZHONG JI SHI BIOTECHNOLOGY CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com