Cosmetic and/or dermatological use of a composition containing at least one oxidation-sensitive hydrophilic active principle and at least one N-vinylimidazole polymer or copolymer
a technology of n-vinyl limicidine and active principle, which is applied in the direction of biocide, plant growth regulator, make-up, etc., can solve the problems of easy decomposition on contact with water, conflict with desired effect, and inability to oxidize in water, so as to improve the synthesis of ceramides and skin barrier function, improve the differentiation of keratinocytes, and improve cosmetic properties
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example 1
[0092] Accelerated Storage Test.
[0093] The aim of this test is to study the decomposition of an oxidation-sensitive hydrophilic active principle after storing for two months at 45.degree. C. Various solutions were prepared and their compositions are collated in the following table:
1TABLE I Solution A Compositions (in water) (Control) Solution B Solution C Solution D Ascorbic acid 15% 15% 15% 15% Polymer 1 -- 1% -- --Polymer 2 -- -- 1% --Polymer 3 -- -- -- 1%
[0094] All the solutions are brought to pH 6 with 8.9 mol / l KOH.
[0095] The percentages of the polymers are given as active material.
[0096] Polymer 1: Vinylpyrrolidone / vinylimidazole (50 / 50) copolymer sold under the reference Luvitec VPI 55K72W of BASF (Weight-average molecular mass 1.2.times.10.sup.6).
[0097] Polymer 2: Vinylpyrrolidone / vinylimidazole (50 / 50) copolymer sold under the reference Luvitec VPI 55K18P of BASF (Weight-average molecular mass 10 000).
[0098] Polymer 3: Polyvinylpyrrolidone sold under the reference Kollidon ...
example 2
[0110] Effect of the Composition According to the Invention on the Differentiation of Keratinocytes
[0111] Principle of the Method:
[0112] The study consists in evaluating the effect of the combination of ascorbic acid and of a polymer or copolymer according to the invention on the differentiation of keratinocytes by measuring the transglutaminase activity (TGk) of cultured human epidermal keratinocytes. The TGk is a marker of the terminal differentiation of the keratinocyte and of the formation of the cornified envelope (corneocyte).
[0113] Human epidermal keratinocytes used at the 3rd passage are inoculated in a 96-well plate at a density of 10 000 cells per well and are cultured in complete SFM medium (Gibco 170005034, EGF and pituitary extract). After preincubating for 24 hours, the cells are brought into contact with the product (tested at 30 .mu.M) for 48 hours. The cells are subsequently washed and then sonicated on ice in Tris / EDTA, pH 8 buffer. The membrane enzyme is extracted...
example 3
[0118] O / W Fluid
[0119] The following composition is prepared in a way conventional to persons skilled in the art.
3 Methyl glucose sesquistearate 2 g Stearyl alcohol and ceteareth-20 2 g Cyclohexasiloxane 10 g Propyl paraben 0.1 g Prunus armeniaca (apricot) kernel oil 6 g Shorea robusta seed butter 2 g Water 13.85 g Methylparaben 0.25 g PEG-20 methyl glucose sesquistearate 2 g Ascorbic acid 5 g Potassium hydroxide (50% solution) 2.97 g Vinylpyrrolidone / vinylimidazole copolymer 1 g Water 41.03 g Polyacrylamide and C.sub.13-14 isoparaffin and Laureth-7 1 g Xanthan gum 0.25 g Chlorohexidine digluconate 0.05 g Water 10.5 g
[0120] A soft and fresh fluid is obtained, which fluid improves the appearance of the skin by virtue of better moisturizing and in which fluid ascorbic acid has good stability.
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