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Microneedle patch and preparing method thereof

A technology of microneedle sticking and microneedle, which is applied in the direction of microneedle, needle, and sheet delivery, which can solve the problems of easy and rapid closure of micropores, residual harmful substances, and poor drug delivery effect, and achieve good skin repair and cosmetic effects. Effects of increasing firmness and reducing wrinkles

Active Publication Date: 2018-12-21
江苏熙美生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with soluble microneedles, coating, hollow and solid solid microneedles are relatively simple to prepare, but they also have their own defects, such as: coated microneedles have a small drug load, and are only suitable for drugs with small therapeutic doses. Difficult to control precisely: the micropores of solid solid microneedles are easy to close quickly after pretreatment, resulting in poor drug delivery effect, and there is the same risk of residual harmful substances after needle breakage as hollow microneedles

Method used

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  • Microneedle patch and preparing method thereof
  • Microneedle patch and preparing method thereof

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preparation example Construction

[0036] The present invention also provides a preparation method for preparing the above-mentioned microneedle patch, which includes: injecting the polymer solution into the micropore cavity of the microneedle mould, by vacuum jetting, and obtaining the needle layer after the polymer solution is solidified. The first side is coated with a dissolvable adhesive, and then a layer of gelatin is poured in. After the gelatin is formed, the cured microneedle patch is taken out from the microneedle mold.

[0037] Specifically, a preparation method of a microneedle patch mainly includes the following steps:

[0038] 1. Preparation of polymer solution

[0039] Dissolve the degradable polymer material in deionized water, prepare an aqueous solution with a mass concentration of 30-50 wt% degradable polymer material, and then add cosmetic functional molecules and reinforcements to the aqueous solution of the degradable polymer material to obtain a polymer solution, the prepared polymer solut...

Embodiment 1

[0048] The embodiment of the present invention provides a microneedle patch and a preparation method thereof.

[0049] 1. Preparation of polymer solution

[0050] Dissolving water-soluble polylactic acid with a molecular weight of 100,000 in deionized water to prepare an aqueous solution with a mass concentration of 40 wt% degradable polymer material;

[0051] According to parts by weight, an aqueous solution of 5 parts of hyaluronic acid, 0.7 parts of carboxymethyl cellulose, 0.7 parts of collagen, 0.7 parts of EGF epidermal growth factor, 1.5 parts of calcium sulfate nano whiskers and 100 parts of degradable polymer materials The polymer solution is obtained by mixing, and the obtained polymer solution is subjected to centrifugation and vacuum filtration for subsequent use.

[0052] 2. Prepare needle layer

[0053] The polymer solution was injected into the microporous cavity of the microneedle mold by vacuum injection, and the microneedle mold injected with the polymer so...

Embodiment 2

[0057] The embodiment of the present invention provides a microneedle patch and a preparation method thereof.

[0058] 1. Preparation of polymer solution

[0059] Dissolving water-soluble polylactic acid with a molecular weight of 200,000 in deionized water to prepare an aqueous solution with a mass concentration of 40 wt% degradable polymer material;

[0060] According to parts by weight, 5 parts of hyaluronic acid, 0.7 part of carboxymethyl cellulose, 0.7 part of collagen, 0.7 part of EGF epidermal growth factor, 0.7 part of kojic acid, 0.7 part of hydroquinone, 0.7 part of arbutin, 0.7 part of AHA, 0.7 vitamin C, 0.7 vitamin E, 0.7 N-acetylglucosamine, 0.7 tranexamic acid, 0.7 L-cysteine, 0.7 glutathione, 0.7 all-trans Retinoic acid, 0.7 part of adenosine, 0.7 part of endothelin antagonist, 0.7 part of mulberry tree extract, 0.7 part of licorice extract, 0.7 part of aloe extract, 1.5 part of calcium sulfate nano whiskers and 100 parts of degradable polymer materials The a...

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Abstract

The invention discloses a microneedle patch and a preparing method thereof, and belongs to the microneedle technology for medical cosmetology. The microneedle patch comprises a needle layer and a lining layer, and the needle layer is connected with the lining layer, wherein the needle layer is prepared from, by weight, 100 parts of degradable polymer materials, 5-10 parts of cosmetic function molecules and 1-2 parts of enhanceosome. A microneedle array can pierce through the skin, the polymer materials in the array can be degraded in the skin and are harmless to the human body, the cosmetic function molecules dissolved in the polymer materials can be released and directly act on the interior of the skin, and thus the effects of replenishing water to the deep layer, reducing wrinkles and beautifying the skin are achieved. The preparing method of the microneedle patch comprises the steps that a vacuum jetting method is adopted for injecting a polymer solution into a micropore cavity of amicroneedle mold, after the polymer solution is cured, the needle layer is obtained, one side of the needle layer is coated with dissoluble binder, then a layer of gelatin is poured, and after the gelatin is formed, the cured microneedle patch is taken out of the microneedle mold.

Description

technical field [0001] The invention relates to the technical field of microneedles for medical cosmetology, and in particular to a microneedle patch and a preparation method thereof. Background technique [0002] As a new dosage form proposed in 1976, microneedle array has a development history of 40 years. The length of the microneedle is generally several hundred microns. When it penetrates the skin, it directly enters the epidermis, breaks through the barrier function of the stratum corneum, and rarely touches the nerve endings located in the dermis, so it will not cause pain. According to different morphological and functional characteristics, microneedles can be divided into solid solid microneedles, hollow microneedles, coated microneedles and soluble microneedles. Soluble microneedles can form self-healing micropores after being pierced into the skin, and can dissolve in the skin by themselves, which greatly improves the transdermal delivery efficiency of macromolec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K9/70A61K47/34A61K47/36A61K47/42A61K8/02A61K8/85A61K8/73A61K8/65A61K8/64A61P17/00A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/0204A61K8/64A61K8/65A61K8/731A61K8/735A61K8/736A61K8/85A61K9/0021A61K47/34A61K47/36A61K47/42A61M37/0015A61M2037/0023A61M2037/0053A61Q19/00A61Q19/02A61Q19/08A61P17/00
Inventor 洪钦杜玉堂鹿文静孔明
Owner 江苏熙美生物科技有限公司
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