According to the research, a novel photooxidation reduction
system based on the photochromic Cu-TiO2 nano-catalyst is developed, and efficient activation and selective
coupling of C-Cl bonds under visible light driving are successfully achieved. Through a dual
reaction path of concerted
catalysis of
benzyl chloride reduction and
phenol oxidation, the
system can directionally synthesize C-C / C-O bond
drug molecules such as 4-benzyloxyphenol (
monobenzone) and benzylated 1, 4-
benzoquinone. Mechanism research shows that
Cu doping enhances the coordination capacity of a substrate, Cu / Cu active sites generated by excitation of
Cu doping have a synergistic effect with
oxygen vacancies, the C-Cl bond activation efficiency is remarkably improved, and efficient synthesis of
bibenzyl (the yield is gt, 96%, and the selectivity is gt, 99%) is achieved. The photooxidation path can be selectively controlled by regulating and controlling the
solvent environment, so that accurate synthesis of high-added-value drugs of different bond type products is realized. The work provides a new thought for developing a high-efficiency photocatalytic
drug synthesis system, and has important guiding significance for functional research of C-Cl bonds.