Composition containing monometallic azelate and monobenzone with skin whitening and skin refining effects and preparation method of composition

A single technology of monobenzone and azelaic acid, which is applied in the field of compositions containing azelaic acid and its metal salts and monobenzone, can solve the problem of large dosage of monobenzone, decreased utilization rate, poor compatibility, etc. question

Inactive Publication Date: 2019-12-31
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent 201610552682.6 provides a freckle-removing and whitening composition containing monobenzone. The dosage of monobenzone is large, and the effect on other skin lesions such as acne is unknown
However, due to its insolubility and poor compatibility, its application is greatly limited, and microcrystalline azelaic acid can be seen in some emulsion products, which greatly reduces its utilization rate.

Method used

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  • Composition containing monometallic azelate and monobenzone with skin whitening and skin refining effects and preparation method of composition
  • Composition containing monometallic azelate and monobenzone with skin whitening and skin refining effects and preparation method of composition
  • Composition containing monometallic azelate and monobenzone with skin whitening and skin refining effects and preparation method of composition

Examples

Experimental program
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Effect test

Embodiment 1

[0038] According to the preparation method provided by the present invention, a composition for whitening and refining the skin is prepared, and the parts by weight of the component raw materials (based on 100 parts by total weight) are as follows:

[0039] Azelaic acid monosodium salt 60 parts

[0040] Monobenzone 40 parts

[0041] The preparation method of the composition for whitening and refining the skin is as follows: mixing monosodium azelaic acid and monobenzone, and grinding to obtain a powder product.

[0042] Application: Take 1g of the above powder products, add them to 10g of a commercially available cosmetic emulsion and 10g of a certain brand of retinoic acid ointment, heat to 75°C under stirring, and after the solids are completely dissolved, the emulsion cosmetics containing this composition are respectively obtained And enhanced tretinoin ointment, can be applied to the skin surface.

[0043] Effect: Through the analysis of melanin inhibition experiment, af...

Embodiment 2-6

[0045] According to the preparation method provided by the present invention, a composition for whitening and refining the skin is prepared, and the parts by weight of the component raw materials (based on 100 parts by total weight) are as follows:

[0046]

[0047] Wherein, X is 5, 10, 15, 20, 30 respectively, and Y corresponds to 15, 10, 10, 15, 5 respectively. The preparation method of the composition for whitening and refining the skin comprises the following steps:

[0048] (1) Add olive oil, lanolin, and monobenzone into the container, heat to 75°C, and after all the components are dissolved, obtain the oil phase component liquid, keep it warm for use; (2) Azelaic acid monosodium salt , sodium oleate, Tween 60, nonylphenol polyoxyethylene ether (OP-10), disodium edetate, glycerin and deionized water were put into another container, heated to 60°C to form a solution, Obtain the water phase component liquid; (3) under stirring, gradually add the water phase component li...

Embodiment 7

[0050] The above monosodium azelaic acid salt in Example 3 was replaced by an equivalent amount of disodium azelaic acid, and the pH of the emulsion was adjusted with salicylic acid so that the pH was the same as in Example 3 to obtain an emulsion product. Inhibition rate test shows that this product effect is equal to embodiment 3.

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Abstract

The present invention provides a composition with skin whitening and skin refining effects. The composition comprises at least (a) azelaic acid or an azelate and (b) monobenzone. The composition can be prepared into powder by mixing and grinding, and can also be prepared into tablets, dispersions, emulsions, gels and pastes to be used for cosmetics for removing freckle, whitening skin and refiningskin. Meanwhile, the invention provides a method for treating skin roughness caused by excessive pigmentation, acne and the like in mammals (including humans). The method comprises applying the composition containing a monometallic azelate and monobenone to skin surfaces of mammals. The synergistic effect generated by the metal azelate and monobenone overcomes the defects that azelaic acid is notproportioned easily and overcomes the defect of an existing tyrosinase inhibitor in treating excessive pigmentation, and multiple effects of bacteriostasis, skin whitening, freckle removal, acne removal and skin refining can be achieved.

Description

technical field [0001] The invention relates to a skin-whitening and thinning composition containing azelaic acid and its salt and monobenzone and a preparation method thereof. More specifically, the present invention relates to compositions containing azelaic acid and its metal salts and monobenzone having enhanced lightening and smoothing capabilities for mammalian skin. Background technique [0002] Pigmentation is the pigmentation change of human skin in different colors and shades in different ranges due to various reasons, which is directly related to the formation of melanin, and the formation of melanin is directly related to tyrosinase. When tyrosinase activity When inhibited, the conversion of tyrosine and cysteine ​​to melanin is reduced, with the end result being whiter skin. [0003] At present, tyrosinase inhibitors are receiving more and more attention in the treatment of hyperpigmentation. Clinically used hydroquinone is a tyrosinase substrate with antagonis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61K8/365A61K8/34A61Q19/02A61P17/08A61P17/10A61P17/16A61Q19/00A61P17/00A61K31/085
CPCA61K31/194A61K31/085A61K8/365A61K8/347A61Q19/02A61Q19/00A61P17/10A61P17/00A61P17/08A61P17/16A61K2800/10
Inventor 张立军马云迪唐慧敏李恒李梦于冰
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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