Particle analog assistant for high-intensity focusing ultrasonic therapy and its uses

A focused ultrasound and high-intensity technology, which is applied in the fields of ultrasound therapy, medicine and medical treatment, can solve problems such as burns, decreased treatment efficiency, and low energy in the target area, and achieve the effects of enhancing absorption characteristics, improving efficiency, and increasing energy deposition

Inactive Publication Date: 2006-07-19
CHONGQING HAIFU (HIFU) TECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when using HIFU technology to treat deep and large tumors, the attenuation of energy will inevitably lead to low energy in the target area, decreased treatment efficiency, and prolonged treatment time.
[0004] Of course, in order to improve the treatment efficiency, the transmission power of the ultrasonic transducer can be simply increased. However, in a high-intensity ultrasonic environment, the possibility of normal tissues on the ultrasonic propagation channel being burned will be greatly increased.
[0005] In addition, when HIFU technology is used clinically to treat liver tumors with ribs blocking the acoustic channel, in order to increase the energy deposition in the treatment target area, improve the treatment speed and treatment effect, it is often necessary to resect the ribs on the acoustic channel before treatment. This is contrary to the concept of HIFU non-invasive treatment, so it is difficult to be recognized by patients and doctors
[0006] The existence of these factors will inevitably affect and limit the promotion and popularization of HIFU as a clinically applicable technology to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]Weigh respectively 4 g of iodized oil for injection (purchased from Shanghai Chemical Reagent Company), 0.6 g of egg yolk lecithin for injection (purchased from Shanghai Chemical Reagent Company), 1.25 g of glycerin for injection (purchased from Shanghai Chemical Reagent Company), mix and heat Dissolve it at 70° C. to form an oil phase, add distilled water containing 1% (W / V) emulsifier F-68 (purchased from Sigma) to the oil phase to 17.5 ml, form colostrum after vigorous shaking. Put the above-mentioned colostrum in a large test tube, ultrasonically emulsify the colostrum for 2 minutes at a power of 350W to form a uniform emulsified lipiodol, and then sterilize it by circulating steam at 100°C for 30 minutes. The pH value is 7.5-8.5 and contains iodine. Amount 0.13g / ml. Particle size <1μm, osmotic pressure 350mosm / kg water.

Embodiment 2～4

[0030] According to the same method and steps described in Example 1, use soybean oil for injection instead of iodized oil for injection as the core material, use lecithin for injection instead of egg yolk lecithin as the film-forming material, according to the formulation listed in Table 1 below Than obtained the following HIFU therapeutic particulate aids of the present invention. The obtained adjuvant is a white milky liquid, which is suitable for intravenous injection of animals and humans, and the corresponding parameters are shown in Table 1 below:

[0031] Example 2

[0032] In the following, the technical effect of the auxiliary agent prepared in the embodiment of the present invention will be described in the form of a test example in combination with the use of HIFU tumor treatment equipment.

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PUM

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Abstract

The invention discloses a particle type auxiliary agent for increasing targeted area tissue energy deposition in HIFU treatment, which includes non-continuous phase constituted by filming material coating and continuous phase constituted by water-based medium, the non-continuous phase is dispersed in the continuous phase homogeneously, grain size of the non-continuous phase is 0.1-8um, the content of the film-forming material in the auxiliary agent is 0.1-100g / L, the core material employs liquid producing no liquid / gas phase change at 38-100 deg C, the content in the auxiliary agent is 5-200g / L. The invention also discloses the use of the particle auxiliary agent in HIFU treatment.

Description

technical field [0001] The present invention relates to the field of medicine and medical treatment, in particular, the present invention relates to the field of ultrasonic therapy, more specifically, the present invention relates to a particulate auxiliary agent for HIFU treatment that can increase the energy deposition of target area tissue during HIFU treatment and its application . Background technique [0002] High-intensity focused ultrasound (HIFU) technology has been clinically recognized as a new method for treating tumors and other diseases. It forms high-intensity and continuous ultrasonic energy on the lesion by focusing ultrasonic waves, thereby producing transient high-temperature effects (65-100°C), cavitation effects, mechanical effects, and sonochemical effects, and selectively causing coagulation necrosis of lesion tissues. The tumor loses the ability to proliferate, invade and metastasize. [0003] Studies have shown that during the propagation of ultras...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/00A61N7/00
CPCA61K9/0019A61K41/0033A61K9/127A61K9/107A61K31/685A61P35/00A61K49/22
Inventor 王智彪李发琪肖雁冰肖子文刘丽萍王芷龙
Owner CHONGQING HAIFU (HIFU) TECHNOLOGY CO LTD
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