Composite nano material with calcium peroxide coated with silicon dioxide as well as preparation method and application thereof

A technology of composite nanomaterials and calcium peroxide, applied in the fields of biomedicine and nanomaterials, can solve problems such as high ultrasonic power, achieve high oxygen efficiency, enhance cavitation effect, and enhance the efficacy of HIFU treatment

Inactive Publication Date: 2021-02-26
SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, during the treatment process, high-intensity focused ultrasound requires high ultrasonic power, which inevitably causes damage to surrounding normal tissues while killing tumor cells.

Method used

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  • Composite nano material with calcium peroxide coated with silicon dioxide as well as preparation method and application thereof
  • Composite nano material with calcium peroxide coated with silicon dioxide as well as preparation method and application thereof
  • Composite nano material with calcium peroxide coated with silicon dioxide as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 200mg CaCl 2 Dissolve in 2ml of aqueous solution, then add 1 mL of ammonia solution (1 M) to the above solution, stir rapidly for 30 minutes, then add 1 mL of 30% H 2 o 2 . Stir the mixed solution at room temperature for another 1 hour, then slowly add NaOH solution 1 mol / L until the clarified solution becomes a white suspension, and finally collect it by centrifugation, and use absolute ethanol (mass percentage concentration: 98% ) was washed several times, and stored in absolute ethanol (98% by mass percentage) at 4°C for future use to obtain calcium peroxide nanomaterials (particle size range data 5-50 nm).

Embodiment 2

[0028] Add 2 mg of calcium peroxide nanomaterials obtained above to 25 ml of absolute ethanol solution (98% concentration by mass), add 0.1 ml of concentrated ammonia water (1 mol / L concentration), and gently stir at room temperature After 1 hour, 0.1 ml of tetraethyl orthosilicate was dissolved in 10 ml of ethanol, added to the above solution, and stirred for 6 hours. Then, the collected product was centrifuged and washed three times with absolute ethanol (98% concentration by mass) to remove impurities to obtain SiO 2 @CaO 2 composite nanomaterials. Finally, the collected product was stored in absolute ethanol (98% by mass) at 4°C for future use.

[0029] Depend on figure 1 It can be seen that SiO can be clearly seen from the high-resolution electron microscope 2 Successfully wrapped in CaO 2 Nanoparticle surface (20 nm for A, 50 nm for B).

[0030] Finally, 100 mg SiO 2 @CaO 2 was dispersed in 40 ml of absolute ethanol (98% by mass). Add 1 mL of 3-aminopropyltrieth...

Embodiment 3

[0033] Observation of SiO under ultrasound 2 @CaO 2 Oxygen production, divided into two groups, one pure water control group, one containing SiO2 2 @CaO2 aqueous solution group. 8 mg SiO 2 @CaO 2 Disperse 100 microliters of aqueous solution in 4 milliliters of water, and then observe under ultrasound, a large number of bubbles can be seen ( figure 2 ).

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Abstract

The invention provides a composite nano material with calcium peroxide coated with silicon dioxide. The composite nano material comprises a calcium peroxide nano material; the surface of the calcium peroxide nano material is coated with the silicon dioxide to form a SiO2-coated CaO2 composite nano material; then the surface of the SiO2-coated CaO2 composite nano material is modified with 3-aminopropyltriethoxysilane to obtain amino-modified SiO2-coated CaO2, i.e. the composite nano material with the calcium peroxide coated with the silicon dioxide. The invention further provides a preparationmethod of the composite nano material. The invention further provides application of the composite nano material in preparation of drugs for enhancing high-intensity focused ultrasound treatment of tumors. According to the composite nano material as well as the preparation method and application thereof, the SiO2-coated CaO2-NH2 nano material reaching a tumor region can be decomposed in a tumor environment to generate oxygen, so that the cavitation effect in the HIFU treatment process is enhanced, and the purpose of enhancing the HIFU treatment effect is achieved.

Description

Technical field: [0001] The invention belongs to the field of biomedicine and nanomaterials, and relates to a calcium peroxide nanomaterial, specifically a composite nanomaterial of silica-wrapped calcium peroxide that can enhance the treatment effect of high-intensity focused ultrasound (HIFU) and its Preparation method and use. Background technique: [0002] High-intensity focused ultrasound therapy is a new type of tumor treatment. When using this method to treat tumors, ultrasonic positioning can be used to focus on the characteristics of a specific target area to generate instantaneous high temperature and cavitation effects, causing coagulation necrosis of the tumor, and achieving minimally invasive treatment of tumor tissue. However, during the treatment process, high-intensity focused ultrasound requires high ultrasound power, which inevitably causes damage to surrounding normal tissues while killing tumor cells. Therefore, further enhancing the therapeutic efficie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/04A61P35/00C01B15/043C01B33/18B82Y30/00B82Y40/00
CPCA61K41/0028A61K9/5115A61P35/00C01B15/043C01B33/18B82Y30/00B82Y40/00C01P2004/04C01P2004/64
Inventor 王春梅
Owner SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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