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Artificial cornea

An artificial cornea, an integrated technology, applied in the field of medical materials, can solve problems such as complex production process, difficult adhesion, aqueous humor leakage, etc., and achieve the effect of good biocompatibility, good optical properties, and firm structure

Inactive Publication Date: 2014-02-12
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, it has been found that the "mirror column-stent" type two-piece artificial cornea has disadvantages such as difficult adhesion, poor joint strength, leakage of aqueous humor, and prone to endophthalmitis, and the production process is complicated and expensive.

Method used

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  • Artificial cornea

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Embodiment Construction

[0029] The technical solutions of the present invention will be further illustrated and described below through specific embodiments.

[0030] Such as figure 1 As shown, an artificial cornea 1 is composed of an optical part 11 and a supporting part 12 integrally formed by three-dimensional printing. The optical part 11 is arranged at the center of the artificial cornea 1, and the supporting part 12 is arranged around the optical part 11 and has a mesh-like porous structure, which is beneficial to the growth of corneal cells and new blood vessels and their extension, forming a natural relationship with the surrounding corneal tissue. Tight connection, the chimera is more firm, and at the same time, some factors that are easy to grow corneal cells can be pre-filled in these mesh porous structures: such as GAG (aminoglucan), FN (fibronectin), etc., and easy to grow new blood vessels Factors: such as VEGF (vascular epidermal growth factor), etc., make corneal fibroblasts and new ...

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Abstract

The invention discloses an artificial cornea which is composed of an optical portion and a supporting portion. The optical portion and the supporting portion are integrally formed through three-dimensional printing, the optical portion is arranged in the center of the artificial cornea, the supporting portion is arranged at the periphery of the optical portion and of a net-shaped multi-hole structure, and accordingly the biological synthesis between the artificial cornea and a receptor tissue is improved. An artificial cornea in the prior art uses a lens column-supporting two-piece mode, an optical portion and a supporting portion of the artificial cornea in the prior art are separated, and aqueous fluid leakage and serous complication like endoophthalmitis are prone to happening after operation to cause transplantation failure. The integrated artificial cornea is manufactured through a three-dimensional printing technique. By means of an integrated structure, the whole artificial cornea is firm and stable in structure, not prone to deforming and capable of solving the problems caused by the two-piece artificial cornea. Individual data models can be manufactured according to parameters of an eyeball in different age groups or CT and UBM three-dimensional scanning parameters of a patient, so that individual artificial cornea can be manufactured.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to an artificial cornea based on three-dimensional printing technology. Background technique [0002] Corneal disease is a common and frequently-occurring disease in ophthalmology. The blindness rate of corneal disease ranks second in the blind epidemiological survey, and 80% of them can be eliminated by corneal transplantation. There are about 4 million blind patients in my country due to corneal diseases, and the national demand for corneas is about 300,000 to 500,000. However, due to the scarcity of corneal resources, only about 5,000 cases of corneal transplants can be performed in the country every year, and many people are blind due to delays in treatment. In addition, severe corneal scar vascularization caused by chemical or thermal burns of both eyes, complete closed symblephagy, severe xerophthalmia corneal vascularization or keratoconjunctival epithelial kerat...

Claims

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Application Information

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IPC IPC(8): A61F2/14A61L27/16A61L27/12A61L27/56A61L27/54
Inventor 李炜张丽颖邹笃雷瞿杨洛娃李三明刘婷婷刘祖国
Owner XIAMEN UNIV
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