Acrylic polymer material with high refractive index

A technology for polymers and medical equipment, which is applied to non-active ingredients in medical preparations, drug combinations, pharmaceutical sciences, etc.

Active Publication Date: 2012-08-01
EYEBRIGHT MEDICAL TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The intraocular lens made of materials with a low Abbe number has a large dispersion difference, which means that light of different wavelengths will focus on different points after passing through the intraocular lens, thus affecting the visual effect of the intraocular lens

Method used

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  • Acrylic polymer material with high refractive index
  • Acrylic polymer material with high refractive index
  • Acrylic polymer material with high refractive index

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0133]

[0134] Weigh 12.17g (0.12mol) of 36% hydrochloric acid in a 100ml three-neck flask, add 20ml of water, add 4.14g (0.03mol) of p-nitroaniline, dissolve into a transparent liquid, cool down to 0-5°C, add dropwise 2.07g ( 0.03mol) sodium nitrite solution, keep warm for 1h and set aside; weigh 3.4g (0.03mol) m-cresol in a 1000ml beaker, add 100ml water, add 1.2g (0.03mol) sodium hydroxide to dissolve. Slowly drop the above diazo solution into the beaker to complete the coupling. Filter, wash and dry.

[0135] Weigh 2.7g (0.01mol) of the above dye into a 100ml three-neck flask, add 40ml of water, add 2.6g (0.02mol) of sodium sulfide solution, heat up to 94-95°C after the addition, and keep it warm for about 1h to complete the reaction. Use 36% hydrochloric acid to adjust the ph to partial acidity, and solids precipitate out, filter, wash with water, and dry. The yield is more than 95%, and the HPLC content is more than 95%.

[0136] Weigh 2.39g (0.01mol) of the above ...

preparation Embodiment 2

[0138]

[0139] Weigh 12.17g (0.12mol) of 36% hydrochloric acid in a 100ml three-neck flask, add 20ml of water, add 4.14g (0.03mol) of p-nitroaniline, dissolve into a transparent liquid, cool down to 0-5°C, add dropwise 2.07g ( 0.03mol) sodium nitrite solution, keep warm for 1h and set aside; weigh 3.4g (0.03mol) m-cresol in a 1000ml beaker, add 100ml water, add 1.2g (0.03mol) sodium hydroxide to dissolve. Slowly drop the above diazo solution into the beaker to complete the coupling. Filter, wash and dry.

[0140] Weigh 2.56g (0.01mol) of the above dye into a 100ml three-neck flask, add 40ml of water, and add 2.6g (0.02mol) of sodium sulfide solution. After the addition, raise the temperature to 94-95°C and keep it warm for about 1 hour to complete the reaction. Use 36% hydrochloric acid to adjust the ph to partial acidity, and solids precipitate out, filter, wash with water, and dry. The yield is more than 95%, and the HPLC content is more than 95%.

[0141] Weigh 2.24g ...

preparation Embodiment 3

[0143]

[0144] Weigh 12.17g (0.12mol) of 36% hydrochloric acid in a 100ml three-neck flask, add 20ml of water, add 4.14g (0.03mol) of p-nitroaniline, dissolve into a transparent liquid, cool down to 0-5°C, add dropwise 2.07g ( 0.03mol) sodium nitrite solution, keep warm for 1h and set aside; weigh 3.4g (0.03mol) m-cresol in a 1000ml beaker, add 100ml water, add 1.2g (0.03mol) sodium hydroxide to dissolve. Slowly drop the above diazo solution into the beaker to complete the coupling. Filter, wash and dry.

[0145]Weigh 2.87g (0.01mol) of the above dye into a 100ml three-neck flask, add 40ml of water, add 2.6g (0.02mol) of sodium sulfide solution, after the addition is complete, raise the temperature to 94-95°C, and keep it warm for about 1h to complete the reaction. Use 36% hydrochloric acid to adjust the ph to partial acidity, and solids precipitate out, filter, wash with water, and dry. The yield is more than 95%, and the HPLC content is more than 95%.

[0146] Weigh 2....

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Abstract

The invention relates to an acrylic polymer material with high refractive index, particularly an acrylic polymer material which has high refractive index and low dispersion deviation and optionally contains blue-light radiation resistance. The material can be used for preparing medical devices, especially preparing eye medical devices, such as artificial lens, contact lens, artificial cornea, cornea inner ring, cornea inner lens, glaucoma valve, drug controlled release carrier, glasses, goggles, medical device lens, telescope, observation mirror. The invention further relates to a polymerisable yellow azo dye which has a maximum absorption wavelength of about 360-370 nm and has methacrylamide nonsaturated group in the structure, thus the effects of effectively absorbing blue lights and / or ultraviolet rays can be achieved.

Description

technical field [0001] The present invention relates to acrylic polymer materials having a high refractive index, in particular, to acrylic polymer materials having a high refractive index, low dispersion bias, and optionally containing anti-blue radiation, which are useful in the preparation of medical devices, in particular To prepare ocular medical devices, such as for the preparation of intraocular lenses, contact lenses, artificial corneas, intracorneal rings, intracorneal lenses, glaucoma drainage valves, drug sustained release carriers, glasses, goggles, medical equipment lenses, telescopes, Observation mirror, etc. The invention also relates to a polymerizable yellow azo dye with a maximum absorption wavelength of about 360-370nm and containing unsaturated methacrylamide groups in its structure, which can effectively absorb blue light and / or ultraviolet rays. Background technique [0002] Medical devices, in particular, the preparation of ophthalmic medical devices,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/18C08F222/14C08F220/60A61L27/16A61K47/32A61P27/02
Inventor 解江冰
Owner EYEBRIGHT MEDICAL TECH BEIJING
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