Composition containing aloe, probiotics and prebiotics and application of composition

A composition and probiotic technology, applied in the directions of medical preparations containing active ingredients, drug combinations, applications, etc., can solve the problems that need to be deepened, and achieve the effects of remarkable effect, scientific and reasonable formulation compatibility, and simple preparation process.

Inactive Publication Date: 2015-07-01
深圳华大基因农业控股有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the current research on regulating the gut microbiota in animals still needs to be in-depth

Method used

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  • Composition containing aloe, probiotics and prebiotics and application of composition
  • Composition containing aloe, probiotics and prebiotics and application of composition
  • Composition containing aloe, probiotics and prebiotics and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] According to the formula shown in Table 1, the composition was prepared according to the following process.

[0035] Table 1 Composition formula of the present invention (weight unit of raw material: part)

[0036]

[0037] The specific operation steps are as follows:

[0038] 1. Aloe vera powder

[0039] The aloe vera powder that the present invention adopts can be derived from the market, and can also be prepared by itself, and the preparation method is a common method.

[0040] 2. Aloe Vera Clostridium Butyricum Propolis Capsules

[0041] Clostridium butyricum strains are cultivated in liquid, collected and washed, and dried to prepare active bacterial powder. Mix aloe vera powder, Clostridium butyricum powder and propolis evenly according to the ratio of 6 / 3 / 1, and then pack it in No. 0 capsules , to obtain aloe Clostridium butyricum propolis capsules, wherein the number of live bacteria of Clostridium butyricum is not less than 1.0×10 8 CFU / g.

[0042] 3. A...

Embodiment 2

[0060] Embodiment 2: determination of acute toxicity

[0061] The acute toxicity test was carried out using 6-week-old special pathogen-free (SPF) SD rats, and the specific operation was as follows:

[0062] Each composition prepared in Example 1 was suspended in 0.5% methylcellulose solution, and was orally administered to 5 SD rats in each group at a dose of 1 g / kg, 5 g / kg and 10 g / kg respectively , observe the death, clinical symptoms and body weight changes of the rats, and conduct blood tests and blood biochemical tests. At the time of autopsy, any abnormalities in the gastrointestinal tissues of the chest and abdomen were visually inspected.

[0063] Experimental results: each composition of the present invention did not cause any specific clinical symptoms, body weight change or death, and there was no change in blood test, blood biochemical test and autopsy. Therefore, since the dose up to 10g / kg does not cause any toxic changes in rats, it can be judged that its medi...

Embodiment 3

[0064] Example 3: Function experiment of regulating human intestinal flora

[0065] According to the Ministry of Health's "Health Food Inspection and Evaluation Technical Specifications (2003)", the evaluation method of human body test food experiment for regulating intestinal flora function, each composition prepared in Example 1 is evaluated, and the specific operation is as follows:

[0066] 1. Grouping of feeding experiments

[0067] The grouping situation of the eating experiment is shown in Table 2:

[0068] Table 2 grouping table of eating experiment

[0069]

[0070]

[0071] 2. Human food test method

[0072] The subjects were randomly divided into 12 groups, 20 people in each group. Before the subjects tried to eat, the feces of the subjects were collected aseptically, and the intestinal flora was tested by 16SrDNA sequencing as a reference for the background level.

[0073] According to the grouping situation in Table 2, group 1 took the control group, grou...

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PUM

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Abstract

The invention discloses a composition and an application thereof in regulating intestinal flora of animals. The composition contains aloe, probiotics and prebiotics, wherein the mass ratio of the aloe to the probiotics to the prebiotics is (6 to 3 to 1)-(6 to 1 to 3). The inventor discovers that the composition disclosed by the invention can effectively promote the proliferation of useful bacteria such as bifidobacterium and lactobacilli in animal intestines, so as to effectively regulate the intestinal flora of animals; therefore, the composition can be used for preventing or treating diabetes on the basis of the effect of the intestinal flora.

Description

technical field [0001] The present invention relates to a composition and its use, in particular to an aloe composition and its use in preparing medicine and food, medicine and food. Background technique [0002] According to research reports, 90% of human cells are not human cells, but microorganisms. Humans and their symbiotic microorganisms together form a "super organism". Therefore, it can be said that the human body has two sets of genomes, one is its own and the other is that of microorganisms. The composition, structure and proportion of intestinal flora are closely related to human health and disease occurrence. Different gut flora profiles can cause or prevent disease; can cause obesity or cause emaciation; can induce diabetes or prevent diabetes. Different flora profiles produce different physiological and pathological effects. They are not only the inducing or initiating factors of health and disease; they are also the "barometer" of health and disease. At pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/886A61K36/896A23L1/09A23L1/29A23L1/08A61P3/10A61K35/741A61K35/644A61K31/702A61K31/733A23L21/25A23L33/00
CPCY02A50/30
Inventor 李晓平刘传张海峰过敏张亮波
Owner 深圳华大基因农业控股有限公司
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