13 results about "Physiologic process" patented technology

The invention relates to the crossing field of artificial intelligence technology and bioinformatics, and discloses a pig feed efficiency prediction model and system based on multi-omics data. Modulating a neural differential equation which runs on a priori knowledge graph and is realized by a graph neural network by using the matrix so as to solve and generate a continuous evolution trajectory of an individual physiological state; and finally, aggregating the tracks, combining the constraint matrix, and outputting a feed efficiency prediction value through a second preset model. The invention further provides a corresponding prediction system which comprises a static constraint module, a dynamic core module and a prediction module. According to the method, static genetic constraint and dynamic physiological process simulation are combined, genetic differences among different individuals can be reflected, and the biological consistency and individualization precision of a prediction model are improved.

In some embodiments, the disposable system includes a multi-channel or multi-chamber test cartridge device configured to operate with a test system for assessing hemostasis in a subject by assessing a test sample from the subject in vitro. In some embodiments, the disposable system is configured to interrogate the test sample to assess clot stiffness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes that occur during coagulation and / or lysis of the resulting clot.

The invention belongs to the technical field of proteomics detection, and particularly relates to a method for detecting mouse liver neomembrane proteome based on an orthogonal translation system and a mouse strain containing an SORT-KASM module. Comprising the following steps: (S.1) constructing a conditionally expressed SORT-KASM transgenic mouse strain; (S.2) activating the expression of the SORT-KAS M by a tissue specific Cre system; (S.3) giving unnatural amino acid ingestion to the mouse; and (S.4) carrying out biotin labeling coupling on non-natural amino acids in the proteome through an azide-alkyne click reaction. According to the detection method, the space and time high resolution of the liver tissue is achieved, the membrane protein has the high-coverage marking capacity, the low-abundance newborn protein has the high-sensitivity marking capacity, good stability is achieved, and the membrane protein participates in the important physiological processes such as substance transfer, energy metabolism and steady state maintaining; the innovation of the detection method provides a new thought for researching the liver cell membrane proteome.

A system for physiological measurement of a physiological process of a body of a patient, the system comprising: at least one physiological sensor operable to collect, at a plurality of different times during a physiological measurement, physiological data from the body of the patient, the physiological data resulting at least from the physiological process; a processor operable to: determine many-valued quality scores for the collected physiological data, each indicative of a suitability of the respective physiological data for the analysis of the physiological process; provide an indication that the physiological measurement was successful in response to determining that an accumulative amount of times, out of the plurality of different times, for which the determined many-valued quality score fulfilled a predetermined criterion, exceeded a predetermined amount; and provide at least part of the physiological measurement to a diagnosing entity.

The invention relates to a method and system for establishing true values in human body state detection. In one embodiment, the disclosure teaches to record physiological data over a continuous duration of at least a threshold duration sufficient to capture a representation of a target state in a biosignal for detection. The recorded data is segmented into shorter analysis windows as a step of proceeding towards persistent state detection, the duration of each window being less than a threshold and marked with a true value indicative of the target state. The windows and tags are stored in non-transitory memory for later use in training, testing, and verifying one or more state prediction models. The method improves the accuracy of the state detection model by providing more typical true values through long-term recordings that capture different manifestations of the body state in the physiological process.

The application relates to a mitochondrial membrane potential detection probe technology, in particular to a dual-color fluorescence probe for self-referenced monitoring of mitochondrial membrane potential and application thereof.The probe comprises a compound CBTH or pharmaceutically acceptable salts, hydrates, solvates, optical isomers, racemates and the like of the compound CBTH.The chemical structural formula of the compound CBTH is shown as formula (I).The probe CBTH can be imaged simultaneously in dual colors, the fluorescence intensity does not disappear with the change of the cell state, and the change of the mitochondrial membrane potential can be monitored semi-quantitatively by calculating the colocalization coefficient.The probe has low toxicity, good biocompatibility, reduces the cumbersome operation of co-staining of two probes, and is expected to be widely applied in the research on diseases and physiological processes related to mitochondria.

The invention belongs to the technical field of material chemistry and biology, and particularly relates to a composite membrane as well as a preparation method and application thereof. According to the HOFilms material, a hydrogen bond organic framework film with high quality and uniform distribution is prepared by using a mild and simple preparation method, and the biological function of the material is effectively reserved; the preparation process is simple, raw materials are easy to obtain, and factory-like large-scale production can be realized; the active achilles tendon regeneration system can be used as a physical barrier or a stent, regulates and repairs a microenvironment at a molecular level, and further forms an integrated active achilles tendon regeneration platform from mechanical support to biological treatment; the HOFilms material has the intelligent characteristic of'wet response ': the HOFilms material not only can stably exist in an in-vivo wet environment, but also can execute specific functions by utilizing or responding to moisture (such as swelling, shrinking and releasing factors) in the environment, so that the HOFilms material interacts with a dynamic physiological process; the HOFilms material has an active biological function of improving an inflammatory microenvironment and directly promoting regeneration of tendon cells, so that healing obstacles are overcome fundamentally.

The invention discloses a malignant tumor treatment simulation system and method considering an immune system, and relates to the field of computational biology and medical informatics. Based on the conceptual model, constructing a mathematical model of interaction between the immune system and the malignant tumor; wherein basic dynamics of cells and factors is reduced by using an ordinary differential equation, and interaction is added on the basis; simulating and verifying the mathematical model based on the biological data to obtain an accurate mathematical model; and performing malignant tumor immunotherapy simulation based on the accurate mathematical model to obtain an immunotherapy simulation effect. By adding an immune system and an escape mechanism, the physiological process of malignant tumor invasion is perfected, an analysis tool is provided for understanding the effect of the immune system in malignant tumor progression, and a theoretical basis is also laid for optimizing an immunotherapy strategy.

The application discloses a hyperuricemia non-human primate model and a construction method thereof, and belongs to the technical field of experimental animals. The construction method comprises the following steps: using a non-human primate, i.e., a cynomolgus monkey, as a model animal, orally administering potassium oxonate and intravenously injecting myo-inositol, so that the blood uric acid content of the cynomolgus monkey is significantly increased within 0.5-8 hours, and the process can be inhibited by a uric acid-lowering drug allopurinol, and based on this, a hyperuricemia model of a non-human primate can be formed. Compared with a model constructed by using rodents, the hyperuricemia non-human primate model constructed by the application can better simulate the related symptoms and physiological processes of human hyperuricemia, and provides a preclinical effect evaluation tool for the research and development of nutrients and drugs in related fields.

The present disclosure relates to methods and systems for establishing ground truth in human state detection. In one embodiment, the disclosure teaches recording physiological data over a continuous duration of at least a threshold duration that is sufficient for capturing representation of the target state in bio signals used for detection. The recorded data is segmented into shorter analysis windows, as a step toward continuous state detection, each window less than the threshold duration, and labeled with a ground truth indicative of the target state. The windows and labels are stored in non-transitory memory, for later use in training, testing, and validating one or more state prediction models. The method enhances the accuracy of state detection models by providing a more representative ground truth through prolonged recordings, which capture the variable manifestations of human states in physiological processes.

The present application belongs to the field of material chemistry and biology technology, and particularly relates to a composite film and a preparation method and application thereof. The HOFilms material of the present application uses a mild and simple preparation method to prepare a high-quality, uniformly distributed hydrogen-bonded organic framework film, effectively retaining the biological function of the material; the production process is simple, raw materials are easy to obtain, and the material can be produced in large scale in a factory; the material can be used as a physical barrier or a support to regulate the repair microenvironment at the molecular level, and further form an integrated active Achilles tendon regeneration platform from mechanical support to biological treatment; the HOFilms material has a "wet response" intelligent property: not only can it stably exist in a wet environment in vivo, but also can utilize or respond to moisture in the environment (such as swelling, shrinking, releasing factors) to perform specific functions, thereby interacting with dynamic physiological processes; the HOFilms material itself has an active biological function, that is, improving the inflammatory microenvironment and directly promoting the regeneration of tendon cells, thereby fundamentally overcoming the healing barrier.

The invention provides an intestinal organ model as well as a culture method and application thereof. The culture method disclosed by the invention is simple and quick to operate, and can be used for culturing the intestinal organ model which is strong in multiplication capacity and high in cell viability and almost contains all functional cells of the small intestine in vivo. Meanwhile, the three-dimensional intestinal organ model obtained by the culture method represents an innovative technology capable of summarizing the whole organism physiological process compared with a traditional two-dimensional culture model, and has the advantages of being closer to physiological cell composition and behavior, more stable in genome, more suitable for biological transfection and high-throughput screening and the like; compared with an animal model, the method is simpler to operate and more convenient for researching mechanisms such as disease occurrence and development; therefore, the method has wide application prospects in the fields of organ development, precision medicine, regenerative medicine, drug screening, gene editing, disease modeling and the like.

The present invention relates to the technical field of biomedicine. The present invention aims to provide a use of Mn3O4 nanoparticles in alleviating intervertebral disc degeneration, trimanganese tetroxide nanoparticles Mn3O4 NPs are added as nanozymes to interventional drugs for treating intervertebral disc degeneration. The present invention uses Mn3O4 nanoparticles as nano-active catalytic enzymes, which have multi-enzyme catalytic activities similar to superoxide dismutase, catalase, and glutathione peroxidase, and can effectively scavenge reactive oxygen species (ROS) and control ECM metabolism, significantly reducing cell apoptosis, delaying cell senescence, inhibiting inflammation, and enhancing autophagy, thereby promoting annulus fibrosus AF repair in the treatment of intervertebral disc degeneration. Mn3O4 nanoparticles have good biocompatibility, and metabolites thereof can be used in other physiological processes, producing no toxic side effects in the in vivo circulation. Furthermore said nanoparticles perform stably in adverse microenvironments of low oxygen and low pH in intervertebral discs, and have in vivo stability that other active catalytic enzymes do not possess.