2 results about "Physiologic process" patented technology

The present application belongs to the field of material chemistry and biology technology, and particularly relates to a composite film and a preparation method and application thereof. The HOFilms material of the present application uses a mild and simple preparation method to prepare a high-quality, uniformly distributed hydrogen-bonded organic framework film, effectively retaining the biological function of the material; the production process is simple, raw materials are easy to obtain, and the material can be produced in large scale in a factory; the material can be used as a physical barrier or a support to regulate the repair microenvironment at the molecular level, and further form an integrated active Achilles tendon regeneration platform from mechanical support to biological treatment; the HOFilms material has a "wet response" intelligent property: not only can it stably exist in a wet environment in vivo, but also can utilize or respond to moisture in the environment (such as swelling, shrinking, releasing factors) to perform specific functions, thereby interacting with dynamic physiological processes; the HOFilms material itself has an active biological function, that is, improving the inflammatory microenvironment and directly promoting the regeneration of tendon cells, thereby fundamentally overcoming the healing barrier.

The present invention relates to the technical field of biomedicine. The present invention aims to provide a use of Mn3O4 nanoparticles in alleviating intervertebral disc degeneration, trimanganese tetroxide nanoparticles Mn3O4 NPs are added as nanozymes to interventional drugs for treating intervertebral disc degeneration. The present invention uses Mn3O4 nanoparticles as nano-active catalytic enzymes, which have multi-enzyme catalytic activities similar to superoxide dismutase, catalase, and glutathione peroxidase, and can effectively scavenge reactive oxygen species (ROS) and control ECM metabolism, significantly reducing cell apoptosis, delaying cell senescence, inhibiting inflammation, and enhancing autophagy, thereby promoting annulus fibrosus AF repair in the treatment of intervertebral disc degeneration. Mn3O4 nanoparticles have good biocompatibility, and metabolites thereof can be used in other physiological processes, producing no toxic side effects in the in vivo circulation. Furthermore said nanoparticles perform stably in adverse microenvironments of low oxygen and low pH in intervertebral discs, and have in vivo stability that other active catalytic enzymes do not possess.