79 results about "Physiologic process" patented technology

Systems and methods are provided for processing and analyzing signals reflecting, physiologic processes and events in a monitored subject, especially cardio-pulmonary signals. The input signals are analyzed by in a physiological domain by creating structured data representing the physiological events reflected in the signals. Preferably, first, primitive event objects are created representing physiologically-significant portions of these input signals; second, the primitive event objects are grouped into primary event objects representing actual physiologic processes and events. Next, all objects are stored in databases, and organized in containers for efficient searching. Information may be retrieved by creating view objects which associate physiologic event objects having selected properties specified directly in physiological terms. This invention includes methods for performing the above analysis, systems and program products for carrying out these methods, and databases configured with the stored objects and views.

A systems biology approach is used to characterize and relate the intestinal (gut) microbiome of a host organism (e.g. a human) to physiological processes within the host. Information regarding the types and relative amounts of gut microflora is correlated with physiological processes indicative of e.g., a patient's risk of developing a disease or condition, likelihood of responding to a particular treatment, for adjusting treatment protocols, etc. The information is also used to identify novel suitable therapeutic targets and / or to develop and monitor the outcome of therapeutic treatments. An exemplary disease / condition is the development of hepatic encephalopathy (HE), particularly in patients with liver cirrhosis.

The invention relates to melanocortin receptor ligands and methods of using the ligands to alter or regulate the activity of a melanocortin receptor. The invention further relates to tetrahydroisoquinoline aromatic amines that function as melanocortin receptor ligands and as agents for controlling cytokine-regulated physiologic processes and pathologies, and combinatorial libraries thereof.

The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

The present invention relates to a novel algorithm that uses molecular profile signatures to extrapolate the physiological processes of one type of cell set (e.g., cell line, tissue, normal or diseased) to predict the activity of an agent or agents against another type of cell set that has never been exposed to the agent in question (drug efficacy prediction). The novel algorithm also allows one to predict the therapeutic response of a patient to a therapeutic regimen even though the patient (or patients) may have never been exposed to that agent before, thereby allowing for selecting a therapeutic agent or combination of agents that would best suit the patient (i.e., personalized medicine). The present invention also relates to methods of using the agents identified by the novel algorithm to treat a variety of diseases, including cancer.

The present invention is the universal unmedicamental system to treat the snore and obstructive sleep apnea and recover of the normal breathing during sleep. The invention includes the device, which ensures the fixation of the tongue in a putting forward beyond the mouth position. As a result, the tongue's pharyngeal part pushes forward in the mouth, releasing besides the throat and excluding the tongue from a system of obstruction to the air's passing through the throat. This increases the throat's capacity, depriving the other throat's structures of the possibility to provoke the partial or complete obstruction to the air's passing through the throat during the physiological process of breathing in the time of the sleep.

A combination of chemical agents reduces reductive stress by limiting the accumulation of high-energy electrons potentially available to the electron transport chain. A method of metabolic uncoupling therapy comprises: analyzing a specific physiologic process involving reductive stress; identifying a plurality of MUT agents that modulate metabolic pathways by influencing electron flux; and formulating a combination of MUT agents that limits the accumulation of high-energy electrons potentially available to the electron transport chain.

The present invention provides methods of detection, including early detection, for cancer or other diseases and normal physiologic processes mediated by global epigenetic changes, by using one or more of the following biomarkers: a global DNA methylation index, a global histone H4 acetylation index, and a global histone H4 trimethylation index. These methods are useful for, among other things, assessing the effectiveness of treatment, monitoring relapse, and clinical staging of cancer and other chronic as well as acute diseases. These methods are also useful for among other things monitoring the effectiveness of strategies and therapies used to modify lifestyle and contextual effects to prevent disease, foster wellness and enable health promotion.

The invention discloses an image attenuation correction method and device and belongs to the technical field of medical imaging. The image attenuation correction method comprises the steps that a first mode image is reconstructed according to first image data and is converted into an attenuation correction image; a second mode image of each gating phase is reconstructed according to second image data; image registration is conducted on the attenuation correction image and the second mode image corresponding to each gating phase to obtain an attenuation correction image of each gating phase; according to the attenuation correction image of each gating phase, the second mode image of each gating phase is reconstructed. The problem is solved that in the relevant art, the matching of PET and CT images is reduced due to the movement in the examination process or the physiological process of a subject, accordingly attenuation correction malposition of the PET images is likely to produce andattenuation artifacts are produced in the PET images, and the advantages of attenuation correction of PET data and quality improvement of PET images are achieved.

This invention encompasses an expeditious method and composition for treating a wide variety of wounds and injuries by promoting the elevation of pH at the site of injury, enhancing the reduction or elimination of pain and scaring from the patho-physiological process of infection proliferation, and promoting enhanced wound care management and wound healing. The invention also provides a method of treating a subject having a condition associated with the presence of free radicals in quantities sufficient to cause undesirable symptoms. The invention encompasses controlling mechanisms of intracellular and extra-cellular ionic physiology through the administration of a composition which includes alkaline salts preferably cesium salts, for pH modulating and for restoring and enhancing the localized cellular ionic physiology. The composition promotes the increase of the electrical current density to certain types of wounds and also functions to treat and / or prevent adhesions resulting from surgeries. The composition simultaneously normalizes the localized ionic environment, thereby normalizing immune responses and reducing acidotic induced pain.

The present invention relates generally to a method of modulating glutathione metabolism in the central nervous system of mammals and to agents for use therein. More particularly, the present invention relates to a method of up-regulating glutathione metabolism in the central nervous system by up-regulating levels of glutathione precursor molecules. The method of the present invention is particularly useful, inter alia, in the treatment and / or prophylaxis of conditions characterised by aberrant, unwanted or otherwise inappropriate central nervous system oxidation homeostasis including, but not limited to, schizophrenia.

The invention provides a simulation and analysis device for physiological processes of urine storage and emiction of the bladder, comprising an artificial bladder, an artificial urethra, a pelvic cavity sink, an extrusion device, a pressure device, a perfusion device, a urine recovery device, a pressure measuring device and a flow metering device. The artificial bladder is used for simulating thefeature that the bladder changes volume along with the liquid capacity and realizing the function of urine storage; the artificial urethra used as a channel for discharging liquid in the bladder; thepelvic cavity sink is used as the environment for containing organs of the bladder, and the like; the extrusion device is used for simulating extrusion caused by the peripheral organs of the bladder to the bladder; the pressure device is used for simulating the shrinkage of detrusor of the bladder so as to realize the function of emiction of the bladder; the perfusion device is used for accuratelymeasuring and displaying the liquid amount perfused to the bladder in real time; the urine recovery device is used as liquid reserve of liquid pumping of the perfusion device and for collecting the liquid discharged from the urethra so as to facilitate recycling; the pressure measuring device is used for measuring and displaying inner pressure of the bladder and the inner pressure of a pelvic cavity in real time; and the flow metering device is used for measuring and displaying the flow of the liquid passing through the urethra in real time. The invention can realize the physiological processes of urine storage and emiction of the artificial bladder, analyzes the physiological process by controlling and monitoring urine dynamical parameters of bladder volume.

A system and method for determining vital sign information of a subject are presented. The system comprises a marker for application to the subject, wherein the marker is configured to change an optical property due to a mechanical manipulation of the marker caused by a physiological process of the subject, a detection unit for detecting radiation from the marker, and an analysis unit for determining the vital sign information of the subject from the detected radiation.

Advanced Islet Separation Technology incorporates an automated method, automated control methodology, process control interface, and automated apparatus to separate (isolate) and process pancreatic islets in a tissue suspension in physiologic process solution, utilizing microprocessor controllers and computer control and software programming to interface and control the process temperature, process flowrate, percent hydrogen concentration, dissolved oxygen concentration, endotoxin concentration, dissolved nitric oxide concentration, nitric oxide synthase concentration, proteolytic enzyme activity, and pressure of the islet containing physiologic process solution, including real-time process data acquisition and recording of the process variables.

A device for treating oral wounds that form a gap and hence too large to suture. The device is intended to fill the resulting wound gap and upon contact with bleeding tissues cause local hemostasis. The device will remain in and protect the wound gap during the healing process. The coagulum plug that is created by this device will eventually heal over as permanent soft tissue and the embedded device removed by the physiological processes of the body. The device is in the shape of a compressible pellet that is packed in the wound gap to help increase retention by exerting an outward pressure. An embodiment of this device is an oxidized cellulose pellet.

The present invention relates generally to a method for modulating steroidogenic activity and a composition useful for same. The present invention further relates to a composition comprising a steroidogenic modulator useful for modulating physiological processes mediated by the androgen receptor or an active form thereof or complex comprising same and / or for modulating physiological processes mediated by estrogen receptors. The composition of the present invention preferably comprises an extract of herbs or botanical or horticultural equivalents of the herbs or chemical or functional equivalents of one or more components of the herbal extract thereof.

Advanced islet separation technology incorporates an automated method, automated control methodology, process control interface, and automated apparatus to separate (isolate) and process pancreatic islets in a tissue suspension in physiologic process solution, utilizing microprocessor control and / or microprocessor computer control and software programming (code) to interface and control the process temperature, fluid flow rate, pH, dissolved oxygen concentration, endotoxin concentration, dissolved nitric oxide concentration, nitric oxide synthase activity, proteolytic enzyme activity, and / or pressure of the islet containing physiologic process solution, the extent of islet separation, including real-time data acquisition and recording of process variables.

The present invention is directed to a physiological recording device and, more particularly, to a physiological recording device that can be used without skin preparation or the use of electrolytic gels. The invention is further directed to an encouragement ring which stabilizes and helps situate the physiological recording device on a subject's skin to help provide a better electrical signal, increase surface area, and reduce and minimize noise and artifacts during the process of recording or monitoring a physiological signal. The invention is still further directed to surface features on a surface of the physiological recording device with a size and shape that will not substantially bend or break, which limits the depth of application of the recording device, and / or anchors the recording device during normal application. The invention is even further directed to a method for manufacturing a physiological recording device, and minimizing cost of manufacture.

This invention provides a biological selective breeding technique in preparation of a transparent zebrafish, Citrine. The appearance of Citrine is transparent and yellowish, with uniformly pigmented black eyes and its inner organs are observable by eyes. The invention also provides a method for in vivo observation of progression and expansion of various disease stages or physiological processes.

A system for automatically evaluating the sensing and detection of physiological processes by an implantable medical device, such as an implantable cardiac stimulation device. The system includes an automatic testing algorithm which iteratively adjusts at least one of the threshold and gain settings of the device and evaluates the accuracy of the detection for refining the programming of the device. The algorithm can include sampling the physiological process beginning at a relatively low rate to avoid excessive burden on the processing and battery capacity available and progressively increasing the rate to obtain higher resolution data. The algorithm can also evaluate the observed physiological process for periodicity and can determine repetition of an irregular pattern, such as bigeminy, and use the determined pattern for predictive purposes to refine the programming of the device. The algorithm employs observation of a change in observed pattern as indicia for loss of proper detection.

A method is provided for treating conditions that are susceptible of treatment with a cytokine wherein certain physiological processes normally associated with cytokine administration (e.g. the induction of SOCS 1 and / or SOCS 3) are diminished or eliminated. The method comprises continuously administering a controlled dose of a cytokine to an individual afflicted with a condition susceptible of treatment with the cytokine.

The present invention is an apparatus for detection of pathological and normal physiological processes in humans and it comprises an electronic nose adapted to detect volatile and non-volatile molecules produced by a human body and a computerized system connected to the electronic nose and to a remote server, and further adapted to receive a molecule detection signals from the electronic nose, and yet further adapted to compare the detected molecules to the molecular combinations stored in its memory, said molecular combinations are indicative of various pathological and / or normal physiological processes in humans.

Recombinant cells and methods are provided that relate to the use of isolated, engineered recombinant cells to directly or indirectly treat diseases or disorders in a mammalian host such as endocrine, gastrointestinal or autoimmune disorders. A recombinant cell is provided that comprises a signal sequence and a promoter, wherein: the signal sequence is capable of regulating signal-dependent expression of a target nucleic acid in a host or is capable of regulating signal-dependent expression of a target nucleic acid in response to an environmental stimulus, the cell is derived from an enteric or a commensal bacterium, and the target nucleic acid encodes a mammalian factor that promotes normal functioning of a physiological process in the host or is effective in preventing onset, establishment, or spread of a non-infectious disease in the host. The recombinant cell is administered to the host to treat the disease or disorder.

The invention discloses an acoustic radiation force enhanced inflammatory cell induced atherosclerosis biomimetic microbubble complex enriching and targeting system. An inflammatory cell induced atherosclerosis biomimetic microbubble complex comprises a CD11b targeting microbubble and an inflammatory cell which are interconnected. The microbubble-CD11b-inflammatory cell complex is successfully constructed by using the connection of a modified microbubble surface group and an activated CD11b molecule on the surface of the inflammatory cell, so the combination of the microbubble with an inflammatory cell in blood through the special CD11b molecule on the inflammatory cell is ensured, and the activation site of the inflammatory cell and blood vessel endothelial adherence and migration is reserved; and the acoustic radiation force is used to enhance the local concentration and the targeting adherence effect of the complex to realize the in-vivo display of the endothelial inflammatory activity in the atherosclerotic part in order to simulate the pathophysiological process of the inflammatory cell induced atherosclerosis, so the system has a great bionic meaning.

The invention discloses a method for building a K+ ion channel on liquid / liquid interfaces. The method for building the K+ ion channel on the liquid / liquid interfaces comprises the following steps that (1) an alumina template is prepared; (2) the prepared alumina template is fixed on a polished smooth plastic pipe through a conductive adhesive, a three-bifurcation pipe is used as an electrolytic tank, organic phases are first added, then a potassium chloride solution is added in the plastic pipe with the fixed alumina template, the plastic pipe is placed on a three-bifurcation main pipe, the alumina template is right located on the interfaces where two solutions are not dissolved with each other, and therefore the ion channel of the liquid / liquid interfaces is formed. The method can be used for simulating a biological membrane and researching the dynamic process that ions pass through the ion channel, has important significance in researching ion transferring, knowing, understanding and mastering a large number of important physiological processes and revealing metabolic processes of substances and energy in biological bodies, and builds a platform for simulating the ions in a biological system.

The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

A method and system of predicting a hypotensive episode in a patient using one or more time varying hypotension specific biomarkers corresponding to physiological processes in the patient. Data derived from sensors or other measurement devices such as ECG sensors can be used to generate biomarkers. The biomarkers can then be used to generate an acute hypotension prediction classifier, or monitored factor, derived from a three dimensional temporal representation of two or more biomarkers. When the monitored factor exceeds a predetermined threshold the method and system trigger an alarm before an appearance of a hypotensive episode in the patient.

The present invention relates to a system (1) and method for determining vital sign information (7) of a subject (100). The system comprises a marker (10, 10', 10'', 40) for application to the subject (100), wherein the marker (10, 10', 10'', 40) is configured to change an optical property due to a mechanical manipulation of the marker (10, 10', 10'', 40) caused by a physiological process of the subject (100), a detection unit (2) for detecting radiation from the marker (10, 10', 10'', 40), and an analysis unit (6) for determining the vital sign information (7) of the subject (100) from the detected radiation.

An implantable medical device system that senses physiologic processes via multiple sensor signal configurations. The device can further process the sensor configurations to obtain additional processed signal configurations. The device can utilize the processed configurations for ongoing sensing of the physiologic process. The device can also automatically evaluate the multiple sensor configurations as well as the processed configurations and select the configuration offering the best signal discrimination to reduce oversensing or erroneously interpreting secondary characteristics of the physiologic process as corresponding to primary characteristics of the process as in double-counting. The signal discrimination can be evaluated as an absolute margin and / or a ratio between amplitudes of the primary and secondary characteristics. The signal discrimination can also be evaluated based at least in part on a calculated mean and standard deviation according to each configuration.

A vitamin, mineral, herbal, and micronutrient treatment for acne via support of the physiologic processes in the body which cause acne is disclosed. It is a targeted formula, designed specifically to address the causes of acne. This specific, unique formulation preferably in a gummy substrate for ease of administration, to induce a willingness on the part of the target population to take it, and to increase the bioavailability of the active ingredients. Other types of confection or edible vehicle can be used.